Results 51 to 60 of about 3,571,432 (328)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Charge lateral diffusion in MIS-HEMTs and its influence on stress and recovery conditions with single and bilayer insulators

Results in Physics
This study investigates the impact of charge trapping and diffusion on the electrical characteristics of gallium nitride (GaN) metal–insulator-semiconductor high electron mobility transistors (MIS-HEMTs) with single layer and bilayer of gate insulator ...
YeonSil Yang, Junseok Heo, Su Yeon Jung, Jongmin Lee, Jang Hyun Kim   +4 more
doaj   +1 more source

Reliable transport through a microfabricated X-junction surface-electrode ion trap

New Journal of Physics, 2013
We report the design, fabrication and characterization of a microfabricated surface-electrode ion trap that supports controlled transport through the two-dimensional intersection of linear trapping zones arranged in a 90° cross.
Kenneth Wright, Jason M Amini, Daniel L Faircloth, Curtis Volin, S Charles Doret, Harley Hayden, C-S Pai, David W Landgren, Douglas Denison, Tyler Killian, Richart E Slusher, Alexa W Harter   +11 more
doaj   +1 more source

Improved tritium retention modeling with reaction-diffusion code TMAP and bulk depth profiling capability

Nuclear Materials and Energy, 2019
ITER-grade tungsten (W) specimens were exposed to similar deuterium (D) plasma condition (ion flux density of 6.0 × 1021 D m − 2s−1, D ion fluence of 5.0 × 1025 D m − 2) at the surface temperature of 623 K.
M. Shimada, C.N. Taylor
doaj   +1 more source

Robust “trapping states” in the motion of a trapped ion [PDF]

Optics Communications, 2004
18 pages, 5 ...
Wallentowitz, S., Vogel, W., Toschek, P. E.   +2 more
openaire   +2 more sources

Reaction blockading in charged-neutral excited-state chemistry at low collision energy

, 2019
We study an excited atom-polar molecular ion chemical reaction (Ca$^*$ + BaCl$^+$) at low temperature by utilizing a hybrid atom-ion trapping system. The reaction rate and product branching fractions are measured and compared to model calculations as a ...
Côté, Robin, Hudson, Eric. R., Mills, Michael, Montgomery, Jr., John A., Puri, Prateek, Schneider, Christian, Simbotin, Ionel, Suits, Arthur G.   +7 more
core   +1 more source

Deterministic cavity quantum electrodynamics with trapped ions [PDF]

, 2003
We have employed radio-frequency trapping to localize a single 40Ca+-ion in a high-finesse optical cavity. By means of laser Doppler cooling, the position spread of the ion's wavefunction along the cavity axis was reduced to 42 nm, a fraction of the ...
B Lange, Berman P R (ed), Gosh P K, H Walther, K Hayasaka, M Keller, Parkins A S, Rempe G, W Lange   +8 more
core   +3 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Evidence for the co-existence of isomers of water dimer radical cations and their inter-conversion in a linear ion trap

Heliyon, 2023
Water dimer radical cations are regarded as key intermediates in many aqueous reactions and biochemical processes. However, the structure of the water dimer radical cations, and particularly the inter-conversion between their isomers, remain difficult to
Xinglei Zhang, Yunpeng Zhang, Xin Zhou, Junqiang Xu, Dongbo Mi   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source