Results 31 to 40 of about 225,515 (313)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Mechanical Properties of Paper Saturated With a Hydrophobic Ionic Liquid

BioResources, 2023
Research into paper-based devices and ionic liquids has increased considerably in the past few years. Thus, the combination of paper-based devices with ionic liquids is also becoming an increasingly frequent research subject.
Christiane Helbrecht, Fabian Schmitt, Tobias Meckel, Markus Biesalski, Bastian J. M. Etzold, Samuel Schabel   +5 more
doaj   +2 more sources

Highly sensitive and fast-responsive room-temperature LPG sensor based on hydrothermally synthesized MoTe2

Frontiers in Nanotechnology
In the current study, a highly efficient and affordable sensor for liquefied petroleum gas (LPG) that operates at ambient temperature was fabricated using a thin film through an easy and low-cost approach. To achieve this objective, MoTe2 was synthesized
Ankit Singh, Avdhesh Kumar, Navin Chaurasiya, Alka Rani, Monu Gupta, B. C. Yadav, Manish Pratap Singh   +6 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Structure and ionic conductivity of ionic liquid embedded PEO- LiCF3SO3 polymer electrolyte

AIP Advances, 2014
In this paper we have reported electrical and other physical properties of polyethylene oxide (PEO) - LiCF3SO3 polymer electrolytes embedded with 1-ethyl-3-methylimidazolium trifluoromethanesulfonate ionic liquid. The addition of the ionic liquid to PEO-
A. Karmakar, A. Ghosh
doaj   +1 more source

Effect of Lipase Ionic Liquid Coating and Imprinting on Transesterification and Thermostability [PDF]

Chemical and Biochemical Engineering Quarterly
This study investigates the effects of the treatments (substrate analogue imprinting and ionic liquid coating) on the catalytic activity and thermostability of lipase from Burkholderia cepacia in the transesterification of vinyl acetate with benzyl ...
M. Matsumoto, Y. Tahara
doaj   +1 more source

Prospects and Design Insights of Neat Ionic Liquids as Supercapacitor Electrolytes

Frontiers in Energy Research, 2021
Ionic liquids present an opportunity to design efficient electrolytes for supercapacitors, which are among the most extensively studied electrochemical energy storage systems. Ionic liquids are promising candidates for supercapacitor electrolytes because
Kallidanthiyil Chellappan Lethesh, Musbaudeen O. Bamgbopa, Rahmat Agung Susantyoko   +2 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The effect of ionic liquid on the solubility of polyetheretherketone (PEEK)

Journal of Ionic Liquids
This paper aims to investigate the suitability of ionic liquids to be used as a co-solvent along with a few common solvents which are dimethyl sulfoxide (DMSO), acetonitrile, and water as the primary solvent to dissolve polyetheretherketone (PEEK).
Norazzah Afizah Jailani, Ainul Haqeem Abdul Jamil, Mohd Hilmi Noh, Muhammad Moniruzzaman   +3 more
doaj   +1 more source