An ionizable lipid toolbox for RNA delivery [PDF]
Nature Communications, 2021 RNA therapeutics have benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development.
Xuexiang Han +6 more
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Ionizable Lipid Containing Nanocarriers for Antimicrobial Agent Delivery [PDF]
Small ScienceAntimicrobial resistance (AMR) poses a global health crisis demanding innovative solutions. Traditional antibiotics, though pivotal over the past century in combating bacterial infections, face diminished efficacy against evolving bacterial defense ...
Haitao Yu +9 more
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Polar/Ionizable residues in transmembrane segments: effects on helix-helix packing. [PDF]
PLoS ONE, 2012 The vast majority of membrane proteins are anchored to biological membranes through hydrophobic α-helices. Sequence analysis of high-resolution membrane protein structures show that ionizable amino acid residues are present in transmembrane (TM) helices,
Manuel Bañó-Polo +5 more
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Boosting ribosomal translation via ionizable lipid-hydrogel microplexes for localized mRNA therapy [PDF]
Bioactive MaterialsmRNA therapy holds immense promise for regenerative medicine; however, localized endoplasmic reticulum stress (ERS) in damaged tissues can impair the critical process of ribosomal translation.
Yanyang Chen +7 more
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Multicomponent thiolactone-based ionizable lipid screening platform for efficient and tunable mRNA delivery to the lungs [PDF]
Communications ChemistryIonizable lipids are essential components of lipid nanoparticles (LNPs) for efficient mRNA delivery. However, designing them for high protein expression, endosomal escape, and organ targeting is challenging due to complex structure-activity relationships.
Álvaro Peña +12 more
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Ionizable lipid nanoparticles of mRNA vaccines elicit NF-κB and IRF responses through toll-like receptor 4 [PDF]
npj VaccinesIonizable lipid nanoparticles (LNP) that have enabled the success of messenger RNA (mRNA) vaccines have been shown to be immunostimulatory in the absence of mRNA.
Amanda E. Zelkoski +7 more
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Lipid Nanoparticles Formulated with a Novel Cholesterol-Tailed Ionizable Lipid Markedly Increase mRNA Delivery Both in vitro and in vivo [PDF]
International Journal of NanomedicineJu Hyeong Jeon,1 Huabin Zhu,1 Jane Qin,1 Luyao Wang,2 Stephanie Mou,1 Laura Katherine Langston,1 Ramesh Marasini,1 Jianzhu Chen,3 Renhuan Xu,1 Shuna Li,2 Xinle Cui1 1ARV Technologies, Inc, North Bethesda, MD, 20852, USA; 2Department of ...
Jeon JH +10 more
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Development of a novel-ionizable-lipid-based mRNA vaccine for broad protection against Streptococcus pneumoniae [PDF]
Molecular Therapy: Nucleic AcidsRecently, messenger RNA (mRNA)-based vaccine technology has made significant advances in preventing pathogenic microbial infections. The composition and physicochemical properties of lipid nanoparticle (LNP) determine the delivery efficiency of mRNA ...
Shi Xu +15 more
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Engineering branched ionizable lipid for hepatic delivery of clustered regularly interspaced short palindromic repeat-Cas9 ribonucleoproteins [PDF]
iScienceSummary: The delivery of the CRISPR/Cas ribonucleoprotein (RNP) has received attention for clinical applications owing to its high efficiency with few off-target effects. Lipid nanoparticles (LNPs) are potential non-viral vectors for the delivery of RNPs.
Haruno Onuma +5 more
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Ionizable Lipids with Triazole Moiety from Click Reaction for LNP-Based mRNA Delivery
Molecules, 2023 Ionizable lipid-containing lipid nanoparticles (LNPs) as a non-viral vector with good safety and potency have been considered as an ideal delivery system for gene therapy.
Yixiang Wang +5 more
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