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Lipid-nanoparticle-induced vacuolization in microglia
Communications BiologyLipid-containing vacuoles in microglia were discovered more than one hundred years ago in the brain of patients showing neurodegenerative processes.
Hubert H. Kerschbaum +5 more
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Effect of gold nanoparticle on structure and fluidity of lipid membrane. [PDF]
PLoS ONE, 2014 This paper deals with the effect of different size gold nanoparticles on the fluidity of lipid membrane at different regions of the bilayer. To investigate this, we have considered significantly large bilayer leaflets and incorporated only one ...
Anil R Mhashal, Sudip Roy
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Machine learning techniques for lipid nanoparticle formulation [PDF]
Nano ConvergenceA significant amount of effort has been poured into optimizing the delivery system that is demanded by novel therapeutic modalities. Lipid nanoparticle presents as a solution to transfect cells safely and efficiently with nucleic acid-based therapeutics.
Hao Li, Yayi Zhao, Chenjie Xu
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Nebulized lipid nanoparticles [PDF]
Nature Reviews Materials, 2021 An article in Nature Biomedical Engineering reports an in vivo workflow for the design of lipid nanoparticles to efficiently deliver mRNA to the lungs via nebulization.
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Molecular Therapy: Methods & Clinical Development, 2023 Crigler-Najjar syndrome is a rare disorder of bilirubin metabolism caused by uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) mutations characterized by hyperbilirubinemia and jaundice.
Jenny A. Greig +9 more
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Tear of lipid membranes by nanoparticles
Soft Matter, 2022 Tear, a direct physical damage of lipid bilayers, can be inflicted by small enough nanoparticles.
Er-Rafik, Meriem +7 more
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Computer Simulations of Lipid Nanoparticles [PDF]
Nanomaterials, 2017 Lipid nanoparticles (LNP) are promising soft matter nanomaterials for drug delivery applications. In spite of their interest, little is known about the supramolecular organization of the components of these self-assembled nanoparticles. Here, we present a molecular dynamics simulation study, employing the Martini coarse-grain forcefield, of self ...
Xavier Fernandez-Luengo +2 more
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Biophysical analysis of lipidic nanoparticles [PDF]
Methods, 2020 Biological nanoparticles include liposomes, extracellular vesicle and lipid-based discoidal systems. When studying such particles, there are several key parameters of interest, including particle size and concentration. Measuring these characteristics can be of particular importance in the research laboratory or when producing such particles as ...
Rozo, Annaïg J. +4 more
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On the Structure of Solid Lipid Nanoparticles [PDF]
Small, 2019 AbstractSolid lipid nanoparticles (SLNs) have a crystalline lipid core which is stabilized by interfacial surfactants. SLNs are considered favorable candidates for drug delivery vehicles since their ability to store and release organic molecules can be tailored through the identity of the lipids and surfactants used.
Demi L. Pink +6 more
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Lipid Nanoparticles for Drug Delivery [PDF]
Advanced NanoBiomed Research, 2021 Lipid nanoparticles have attracted significant interests in the last two decades, and have achieved tremendous clinical success since the first clinical approval of Doxil in 1995. At the same time, lipid nanoparticles have also demonstrated enormous potential in delivering nucleic acid drugs as evidenced by the approval of two RNA therapies and mRNA ...
Letao Xu +5 more
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