Results 21 to 30 of about 2,353,041 (346)
Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers: A Comparative Review
Pharmaceutics, 2023 Solid–lipid nanoparticles and nanostructured lipid carriers are delivery systems for the delivery of drugs and other bioactives used in diagnosis, therapy, and treatment procedures. These nanocarriers may enhance the solubility and permeability of drugs,
Cláudia Viegas +5 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Genome editing technologies enable the permanent repair of disease-causing genetic mutations. However, the application of this technology has been limited by the technical challenge of achieving safe, effective, and specific in vivo delivery
Min Qiu +10 more
semanticscholar +1 more source
Development of an mRNA-lipid nanoparticle vaccine against Lyme disease
Molecular Therapy, 2023 Lyme disease is the most common vector-borne infectious disease in the United States, in part because a vaccine against it is not currently available for humans. We propose utilizing the lipid nanoparticle-encapsulated nucleoside-modified mRNA (mRNA-LNP)
Matthew Pine +14 more
semanticscholar +1 more source
Advances in Pancreatic Cancer Treatment by Nano-Based Drug Delivery Systems
Pharmaceutics, 2023 Pancreatic cancer represents one of the most lethal cancer types worldwide, with a 5-year survival rate of less than 5%. Due to the inability to diagnose it promptly and the lack of efficacy of existing treatments, research and development of innovative ...
Cláudia Viegas +6 more
doaj +1 more source
Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines
Proceedings of the National Academy of Sciences of the United States of America, 2023 Significance A major unmet need in the advancement of lipid nanoparticles (LNPs) for RNA therapeutics and vaccines is the development of formulation technologies that can generate LNPs across the various scales of drug development, from small-scale ...
Sarah J. Shepherd +12 more
semanticscholar +1 more source
Molecular Therapy: Nucleic Acids, 2022 Arginase deficiency is associated with prominent neuromotor features, including spastic diplegia, clonus, and hyperreflexia; intellectual disability and progressive neurological decline are other signs.
Suhail Khoja +14 more
doaj +1 more source
A saposin-lipoprotein nanoparticle system for membrane proteins. [PDF]
, 2016 A limiting factor in membrane protein research is the ability to solubilize and stabilize such proteins. Detergents are used most often for solubilizing membrane proteins, but they are associated with protein instability and poor compatibility with ...
Armache, Jean-Paul +13 more
core +2 more sources
Molecular Therapy: Nucleic Acids, 2016 The androgen receptor plays a critical role in the progression of prostate cancer. Here, we describe targeting the prostate-specific membrane antigen using a lipid nanoparticle formulation containing small interfering RNA designed to silence expression ...
Justin B Lee +13 more
doaj +1 more source
Lipid nanoparticle-mediated mRNA delivery in lung fibrosis
European Journal of Pharmaceutical Sciences, 2023 mRNA delivery enables the specific synthesis of proteins with therapeutic potential, representing a powerful strategy in diseases lacking efficacious pharmacotherapies.
Matteo Massaro +9 more
semanticscholar +1 more source
Indonesian Journal of Chemistry, 2018 Lipid nanoparticles, one of nanoparticle technology results has been developed both as a drug delivery system and as a research object. Complex lipid nanoparticle, in the drug delivery system development, has an advantage due to its less toxicity.
Rini Dwiastuti +3 more
doaj +1 more source