Results 21 to 30 of about 88,630 (306)

Lipid Nanoparticles for the Posterior Eye Segment [PDF]

Pharmaceutics, 2021
This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles, Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for pathologies affecting the posterior ocular segment. Eye anatomy and the most relevant diseases affecting the posterior segment will be summarized. Moreover, preparation methods
Lorena Bonilla, Marta Espina, Patricia Severino, Amanda Cano, Miren Ettcheto, Antoni Camins, Maria Luisa García, Eliana B. Souto, Elena Sánchez-López   +8 more
openaire   +5 more sources

A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo

Molecular Therapy: Nucleic Acids, 2016
The androgen receptor plays a critical role in the progression of prostate cancer. Here, we describe targeting the prostate-specific membrane antigen using a lipid nanoparticle formulation containing small interfering RNA designed to silence expression ...
Justin B Lee, Kaixin Zhang, Yuen Yi C Tam, Joslyn Quick, Ying K Tam, Paulo JC Lin, Sam Chen, Yan Liu, Jayaprakash K Nair, Ivan Zlatev, Kallanthottathil G Rajeev, Muthiah Manoharan, Paul S Rennie, Pieter R Cullis   +13 more
doaj   +1 more source

Intermittent lipid nanoparticle mRNA administration prevents cortical dysmyelination associated with arginase deficiency

Molecular Therapy: Nucleic Acids, 2022
Arginase deficiency is associated with prominent neuromotor features, including spastic diplegia, clonus, and hyperreflexia; intellectual disability and progressive neurological decline are other signs.
Suhail Khoja, Xiao-Bo Liu, Brian Truong, Matthew Nitzahn, Jenna Lambert, Adam Eliav, Eram Nasser, Emma Randolph, Kristine E. Burke, Rebecca White, Xuling Zhu, Paolo G.V. Martini, Itzhak Nissim, Stephen D. Cederbaum, Gerald S. Lipshutz   +14 more
doaj   +1 more source

Delivery of oligonucleotides with lipid nanoparticles [PDF]

Advanced Drug Delivery Reviews, 2015
Since their inception in the 1980s, oligonucleotide-based (ON-based) therapeutics have been recognized as powerful tools that can treat a broad spectrum of diseases. The discoveries of novel regulatory methods of gene expression with diverse mechanisms of action are still driving the development of novel ON-based therapeutics.
Yuhua, Wang, Lei, Miao, Andrew, Satterlee, Leaf, Huang   +3 more
openaire   +2 more sources

Analytical Method Validation and Determination of Free Drug Content of 4-n-Butylresorcinol in Complex Lipid Nanoparticles Using RP-HPLC Method

Indonesian Journal of Chemistry, 2018
Lipid nanoparticles, one of nanoparticle technology results has been developed both as a drug delivery system and as a research object. Complex lipid nanoparticle, in the drug delivery system development, has an advantage due to its less toxicity.
Rini Dwiastuti, Marchaban Marchaban, Enade Perdana Istyastono, Florentinus Dika Octa Riswanto   +3 more
doaj   +1 more source

Improved Bioavailability of Poorly Soluble Drugs through Gastrointestinal Muco-Adhesion of Lipid Nanoparticles

Pharmaceutics, 2021
Gastrointestinal absorption remains indispensable in the systemic delivery of most drugs, even though it presents several challenges that, paradoxically, may also provide opportunities that can be exploited to achieve maximal bioavailability.
Sui Ling Janet Tan, Nashiru Billa
doaj   +1 more source

Hydrophobic silver nanoparticles trapped in lipid bilayers: Size distribution, bilayer phase behavior, and optical properties

Journal of Nanobiotechnology, 2008
Background Lipid-based dispersion of nanoparticles provides a biologically inspired route to designing therapeutic agents and a means of reducing nanoparticle toxicity.
Bothun Geoffrey D
doaj   +1 more source

Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization

Pharmaceutics, 2020
Background: Capsaicin (CPS) is a highly selective agonist of the transient receptor potential vanilloid type 1 (TRPV1) with a nanomolar affinity. High doses or prolonged exposure to CPS induces TRPV1 defunctionalization and, although this effect is ...
Carmelo Puglia, Debora Santonocito, Angela Bonaccorso, Teresa Musumeci, Barbara Ruozi, Rosario Pignatello, Claudia Carbone, Carmela Parenti, Santina Chiechio   +8 more
doaj   +1 more source

Higher or Lower? - The Resolution of Analytical Pipelines for the Evaluation of Lipid Nanoparticle Critical Quality Attributes

British Journal of Pharmacy, 2023
Dynamic light scattering (DLS) is a routinely used analytical technique to measure the size distribution of a colloidal sample. Nanoparticle tracking analysis (NTA) has more recently emerged as an orthogonal technique to determine particle size and ...
Callum George Davidson, Rand Abdulrahman, Michael Cairns, Yvonne Perrie , Zahra Rattray   +4 more
doaj   +1 more source

Lipid nanoparticles with ionizable lipids: Statistical aspects

Physical Review E, 2022
Lipid nanoparticles (LNPs) with size ∼100 nm are now used for fabrication of a new generation of drugs and antiviral vaccines. To optimize their function or, more specifically, interaction with cell membranes, their composition often includes ionizable lipids which are neutral or cationic (after association with H^{+}).
openaire   +2 more sources