Results 41 to 50 of about 88,630 (306)

Nanoparticle-Induced Disorder at Complex LiquidLiquid Interfaces: Effects of Curvature and Compositional Synergy on Functional Surfaces

, 2021
The self-assembly of surfactant monolayers at interfaces plays a sweeping role in tasks ranging from household cleaning to the regulation of the respiratory system. The synergy between different nanoscale species at an interface can yield assemblies with
Ying-Zhong Ma (1343253), Stephen A. Sarles (1473421), Francesco Stellacci, Ying-Zhong Ma, Colin M. Basham (11427385), Francesco Stellacci (824625), Uvinduni I. Premadasa (5879186), Benjamin Doughty, Colin M. Basham, Stephen A. Sarles, Benjamin Doughty (1362744), Uvinduni I. Premadasa   +11 more
core   +1 more source

Lipid Membranes as Solvent for Carbon Nanoparticles [PDF]

Biophysical Journal, 2014
Fullerene is scarcely soluble in most solvents, including alkanes. Yet, it has been shown that C60 dissolves in lipid bilayers, whose interior is chemically identical to alkanes. Here, we use molecular simulations to explain why lipid bilayers are better than alkanes at dissolving fullerene clusters.
J. Barnoud, ROSSI, GIULIA, L. Monticelli
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Research Advances on the Stability of mRNA Vaccines

Viruses, 2023
Compared to other vaccines, the inherent properties of messenger RNA (mRNA) vaccines and their interaction with lipid nanoparticles make them considerably unstable throughout their life cycles, impacting their effectiveness and global accessibility.
Feiran Cheng, Yiping Wang, Yu Bai, Zhenglun Liang, Qunying Mao, Dong Liu, Xing Wu, Miao Xu   +7 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

mRNA lipid nanoparticle phase transition

, 2022
The repository contains input files and data from the manuscript: Trollmann, Marius F.W. and Böckmann, Rainer A. "mRNA lipid nanoparticle phase transition", Biophysical Journal (2022) https://doi.org/10.1016/j.bpj.2022.08.037 > Periodic membrane ...
Böckmann, Rainer A., Trollmann, Marius F.W.   +1 more
core   +1 more source

Cytotoxic Effects of Fucoidan Nanoparticles against Osteosarcoma

Marine Drugs, 2013
In this study, we analyzed the size-dependent bioactivities of fucoidan by comparing the cytotoxic effects of native fucoidan and fucoidan lipid nanoparticles on osteosarcoma in vitro and in vivo. In vitro experiments indicated that nanoparticle fucoidan
Ryuichiro Kimura, Takayoshi Rokkaku, Shinji Takeda, Masachika Senba, Naoki Mori   +4 more
doaj   +1 more source

Treatment With Methotrexate Associated With Lipid Core Nanoparticles Prevents Aortic Dilation in a Murine Model of Marfan Syndrome

Frontiers in Cardiovascular Medicine, 2022
In Marfan syndrome (MFS), dilation, dissection, and rupture of the aorta occur. Inflammation can be involved in the pathogenicity of aortic defects and can thus be a therapeutic target for MFS.
Maria Carolina Guido, Natalia de Menezes Lopes, Camila Inagaki Albuquerque, Elaine Rufo Tavares, Leonardo Jensen, Priscila de Oliveira Carvalho, Thauany Martins Tavoni, Ricardo Ribeiro Dias, Lygia da Veiga Pereira, Francisco Rafael Martins Laurindo, Raul Cavalcante Maranhão   +10 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source