Results 61 to 70 of about 2,353,041 (346)
Can pulsed electromagnetic fields trigger on-demand drug release from high-tm magnetoliposomes? [PDF]
, 2018 Recently, magnetic nanoparticles (MNPs) have been used to trigger drug release from magnetoliposomes through a magneto-nanomechanical approach, where the mechanical actuation of the MNPs is used to enhance the membrane permeability.
Apollonio, Francesca +7 more
core +2 more sources
Lipid nanoparticle topology regulates endosomal escape and delivery of RNA to the cytoplasm
bioRxiv, 2022 RNA therapeutics have the potential to resolve a myriad of diseases caused by gene deficiency. Lipid nanoparticles (LNPs) are one of the most successful RNA delivery systems. However, expanding their application hinges on the discovery of next generation
Lining Zheng +2 more
semanticscholar +1 more source
Shaping nanoparticle fingerprints at the interface of cholesteric droplets
, 2018 The ordering of nanoparticles into predetermined configurations is of importance to the design of advanced technologies. In this work, we moderate the surface anchoring against the bulk elasticity of liquid crystals to dynamically shape nanoparticle ...
Haase, Martin F. +6 more
core +1 more source
Self-assembling nanoparticles containing dexamethasone as a novel therapy in allergic airways inflammation. [PDF]
, 2013 Nanocarriers can deliver a wide variety of drugs, target them to sites of interest, and protect them from degradation and inactivation by the body. They have the capacity to improve drug action and decrease undesirable systemic effects.
Bratt, Jennifer M +6 more
core +2 more sources
From lipids to lipid nanoparticles to mRNA vaccines [PDF]
Nature Reviews Materials, 2021 Lipid nanoparticles are essential to mRNA vaccines. The groundwork for lipid-based drug delivery systems was laid more than 40 years ago in the lab of Pieter Cullis, Professor at the University of British Columbia. Nature Reviews Materials talks to Pieter Cullis about the history and future of lipid nanoparticle-nucleic acid drugs.
openaire +2 more sources
Lipid Nanoparticle-Mediated Liver-Specific Gene Therapy for Hemophilia B
PharmaceuticsBackground/Objectives: Hemophilia B is a hereditary bleeding disorder due to the production of liver malfunctional factor IX (FIX). Gene therapy with viral vectors offers a cure.
Brijesh Lohchania +5 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Research Advances on the Stability of mRNA Vaccines
Viruses, 2023 Compared to other vaccines, the inherent properties of messenger RNA (mRNA) vaccines and their interaction with lipid nanoparticles make them considerably unstable throughout their life cycles, impacting their effectiveness and global accessibility.
Feiran Cheng +7 more
doaj +1 more source
Synthesis and Characterization of Lipid Coated Nanoparticles as Drug Delivery Vehicles [PDF]
, 2017 Spherical monodisperse nanoparticles composed of gold or silver cores were modified with lipids as part of an ongoing project to utilize functionalized nanoparticles as drug delivery vehicles.
Gilbert, Brian D. +1 more
core +1 more source
Extracellular Vesicles and Circulating Nucleic AcidsThe rise of biologics and RNA-based therapies challenges the limitations of traditional drug treatments. However, these potent new classes of therapeutics require effective delivery systems to reach their full potential.
Lasse Hagedorn +3 more
semanticscholar +1 more source