Results 61 to 70 of about 88,630 (306)

Human Gut Bacteria and Lipidic Nanoparticles: Particle Composition Predicts Structural Transformation and Bacterial Biocompatibility

Advanced Functional Materials, EarlyView.
Lipidic nanoparticles (LNPs) were incubated with 21 gut bacteria frequently associated with the human microbiome. SAXS revealed that ∼75% of tested species induced structural transformations in monoolein LNPs, whereas phytantriol and phospholipid formulations remained unaffected.
Jonathan Caukwell, Emily L. Gulliver, Livia Salvati Manni, Frithjof Herb, Caitlin Welsh, Samuel C. Forster, Andrew J. Clulow, Wye‐Khay Fong   +7 more
wiley   +1 more source

Navigating the challenges of lipid nanoparticle formulation:the role of unpegylated lipid surfactants in enhancing drug loading and stability

, 2023
Lipid nanoparticles have proved an attractive approach for drug delivery; however, the challenges of optimising formulation stability and increasing drug loading have limited progression.
Arnold, K, Wright, S, Elkateb, H, McDonald, Tom; id_orcid, Rannard, S, Elkateb, Heba, McDonald, TO, Arnold, Keith, Rannard, Steve, Wright, Steve, Hogarth, C, Hogarth, Cameron   +11 more
core   +1 more source

Cyclic Olefin Copolymers as Versatile Materials for Advanced Engineering Applications

Advanced Functional Materials, EarlyView.
Cyclic olefin copolymers (COCs) are presented as highly versatile materials combining tunable synthesis, excellent optical properties, and mechanical robustness. Their potential spans microfluidics, bioengineering, and advanced electronics, while emerging self‐healing and sustainable solutions highlight future opportunities.
Giulia Fredi, Norma Mallegni, Andrea Dorigato, Mario Milazzo   +3 more
wiley   +1 more source

Lipid nanoparticle of polymyxin [PDF]

, 2014
The present invention is related to a lipid nanoparticle comprising at least one antibiotic from the polymyxin family, a lipid fraction and one or more surfactants.
Pozo, Ángel del, Bachiller, Daniel, Villullas Rincón, Silvia, Pedraz Muñoz, José Luis, Esquisabel Alegría, Amaia, Ibarrola Moreno, Oihane, Fusté Domínguez, Ester, Gil Martín, Iraida, Fernández Plagaro, Raúl, Gainza Lucea, Garazi, Pastor, Marta, Sans, Eulàlia   +11 more
core  

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

Advanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett, Shahad K. Alsaiari, John L. Daristotle, Timothy A. Forster, Alicia Lau, Dhruv Varshney, Rania Afaneh, Andrew R. Hanna, Charles Sloane, David Mankus, Haitao Yu, Jiali Zhai, DongSoo Yun, Lisa H. Tostanoski, Abigail Lytton‐Jean, Dan H. Barouch, Charlotte E. Conn, Robert Langer, Ana Jaklenec, Calum J. Drummond   +19 more
wiley   +1 more source

Swelling‐Induced Stress‐Assisted Transfer of Nanodiamond Arrays With a PVA Carrier Tape for Conformal Bio‐Integrated Sensing and Labelling

Advanced Functional Materials, EarlyView.
This work introduces a swelling‐induced, stress‐assisted water‐soluble PVA tape strategy to transfer‐print nanodiamond quantum‐sensor arrays onto soft, curved biological interfaces. The room‐temperature, water‐triggered process achieves >98% fidelity and residue‐free integration, enabling conformal quantum sensing on contact lenses, neural probes, and ...
Luyao Zhang, Lingzhi Wang, Xinhao Hu, Tai Nam Yip, Mingze Sun, Jixiang Jing, Lizhi Xu, Yuan Lin, Yong Hou, Zhiqin Chu   +9 more
wiley   +1 more source

Lipid Corona Formation from Nanoparticle Interactions with Bilayers and Membrane-Specific Biological Outcomes

, 2017
While mixing nanoparticles with certain biological molecules can result in coronas that afford some control over how engineered nanomaterials interact with living systems, corona formation mechanisms remain enigmatic.
Dehong, Hu, Catherine J., Murphy, Gene, Chong, Angela, Schmoldt, Joel A., Pedersen, Qiang, Cui, Thomas R, Kuech, Arielle C, Mensch, Xi, Zhang, Laura L., Olenick, Ariane, Vartanian, Franz, Geiger, Katherine R., Hurley, Augusto, Millevolte, Alicia C., McGeachy, Aurash, Mohaimani, Eric S., Melby, Stephanie R., Walter, Rebecca, Klaper, Julianne M., Troiano, Jared, Bozich, Christy L., Haynes, Jiewei, Hong, Marco D., Torelli, Merve, Dogangun, Leili, Zhang, Tianzhe, Li, Samuel, Lohse, Rigoberto, Hernandez, Ian, Gunsolus, Z. Vivian, Feng, Robert J., Hamers, Tian, Qiu, Joe, Dalluge, Galya, Orr   +34 more
core   +1 more source

Investigations Into the Influence of Ionizable Lipids on the Stability of Lipid Nanoparticle

MedComm – Biomaterials and Applications
Messenger RNA‐loaded lipid nanoparticles (mRNA@LNPs) have achieved remarkable success in vaccine development, but their long‐term preservation imposes stringent requirements for transportation and storage. To broaden application of this technology, it is
Jie Wang, Zhitong Guo, Jun Yang, Haiyin Yang, Shaoping Jiang, Abid Naeem, Bo Hu, Yuhua Weng, Yuanyu Huang   +8 more
doaj   +1 more source

Simple Scattering: Lipid nanoparticle structural data repository

Frontiers in Molecular Biosciences
Lipid nanoparticles (LNPs) are being intensively researched and developed to leverage their ability to safely and effectively deliver therapeutics.
Lee Joon Kim, David Shin, Wellington C. Leite, Hugh O’Neill, Oliver Ruebel, Andrew Tritt, Greg L. Hura, Greg L. Hura   +7 more
doaj   +1 more source

Blood Biomarkers and Surface‐Enhanced Raman Spectroscopy for Gout: A Comprehensive Review

Advanced Functional Materials, EarlyView.
Schematic illustrating gout disease progression from asymptomatic hyperuricemia to chronic tophaceous disease, highlighting the limitations of conventional imaging and biochemical diagnostics and the potential of engineered SERS platforms for ultrasensitive blood‐based detection of urate‐related biomarkers across disease stages, with the color gradient
Isuri Perera, Chiranjeevi Kanike, Appurva Tiwari, Hongyan Wu, Larry D. Unsworth, Ben Bin Xu, Xuehua Zhang   +6 more
wiley   +1 more source