Results 81 to 90 of about 2,353,041 (346)

An Overview of Nanoparticle-Based Delivery Platforms for mRNA Vaccines for Treating Cancer

Vaccines
With its unique properties and potential applications, nanoparticle-based delivery platforms for messenger RNA (mRNA) vaccines have gained significant attention in recent years.
Yang Lin, Xuehua Chen, Ke Wang, Li Liang, Hongxia Zhang   +4 more
doaj   +1 more source

Optimization of storage conditions for lipid nanoparticle-formulated self-replicating RNA vaccines

Journal of Controlled Release, 2022
The recent clinical success of multiple mRNA-based SARS-CoV-2 vaccines has proven the potential of RNA formulated in lipid nanoparticles (LNPs) in humans, and products based on base-modified RNA, sequence-optimized RNA, and self-replicating RNAs ...
Byungji Kim, Ryan R Hosn, Tanaka Remba, DongSoo Yun, Na Li, W. Abraham, M. Melo, M. Cortés, Bridget Li, Yuebao Zhang, Yizhou Dong, D. Irvine   +11 more
semanticscholar   +1 more source

Lipid Nanoparticles for Gene Delivery [PDF]

, 2014
Nonviral vectors which offer a safer and versatile alternative to viral vectors have been developed to overcome problems caused by viral carriers. However, their transfection efficacy or level of expression is substantially lower than viral vectors. Among various nonviral gene vectors, lipid nanoparticles are an ideal platform for the incorporation of ...
Yi, Zhao, Leaf, Huang
openaire   +2 more sources

Key Design Features of Lipid Nanoparticles and Electrostatic Charge-Based Lipid Nanoparticle Targeting

Pharmaceutics, 2023
Lipid nanoparticles (LNP) have gained much attention after the approval of mRNA COVID-19 vaccines. The considerable number of currently ongoing clinical studies are testament to this fact. These efforts towards the development of LNPs warrant an insight into the fundamental developmental aspects of such systems.
Vijay Gyanani, Roshan Goswami
openaire   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Toxoplasma gondii GRA15 DNA Vaccine with a Liposomal Nanocarrier Composed of an SS-Cleavable and pH-Activated Lipid-like Material Induces Protective Immunity against Toxoplasmosis in Mice

Vaccines, 2021
Toxoplasma gondii affects the health of humans and livestock and causes severe illness in the fetus and immunocompromised individuals. Because of the high incidence and severe consequences of T. gondii infection, a safe and suitable vaccine is needed. We
Tanjila Hasan, Ryo Kawanishi, Hidetaka Akita, Yoshifumi Nishikawa   +3 more
doaj   +1 more source

Cellular trafficking of Sn-2 phosphatidylcholine prodrugs studied with fluorescence lifetime imaging and super-resolution microscopy [PDF]

, 2018
While ...
Achilefu, Samuel, Cui, Grace, Lanza, Gregory M, Lew, Matthew D, Lu, Jin, Maji, Dolonchampa, Pan, Dipanjan, Sarder, Pinaki, Schmieder, Anne H, Yang, Xiaoxia   +9 more
core   +1 more source

Hybrid plasmonic photoreactors as visible light-mediated bactericides [PDF]

, 2020
Photocatalytic compounds and complexes, such as tris(bipyridine)ruthenium(II), [Ru(bpy)3]2+, have recently attracted attention as light-mediated bactericides that can help to address the need for new antibacterial strategies.
An, Xingda, Liu, Pinghua, Naowarojna, Nathchar, Reinhard, Björn M.   +3 more
core   +1 more source

Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice

Nature Communications, 2020
The spread of the SARS-CoV-2 into a global pandemic within a few months of onset motivates the development of a rapidly scalable vaccine. Here, we present a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid ...
P. Mckay, Kai Hu, A. Blakney, K. Samnuan, Jonathan C. Brown, R. Penn, Jie Zhou, Clément R. Bouton, Paul Rogers, Krunal Polra, Paulo J C Lin, Chris Barbosa, Ying K. Tam, W. Barclay, R. Shattock   +14 more
semanticscholar   +1 more source

Lipid Nanoparticle-mRNA Formulations for Therapeutic Applications.

Accounts of Chemical Research, 2021
ConspectusAfter decades of extensive fundamental studies and clinical trials, lipid nanoparticles (LNPs) have demonstrated effective mRNA delivery such as the Moderna and Pfizer-BioNTech vaccines fighting against COVID-19.
Chang Wang, Yuebao Zhang, Yizhou Dong
semanticscholar   +1 more source