Results 91 to 100 of about 2,353,041 (346)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Lipid-Based Nanoparticles

Journal of Innovations in Applied Pharmaceutical Science (JIAPS)
Lipid-based nanoparticles (LNPs) are nano-sized particles composed of lipids, which are natural or synthetic molecules. It comprises of phospholipid bilayer in its structure. The unique properties of lipids such as biocompatibility and versatility, have spurred the development of various lipid based nano formulations.
Sindhu Gillella, Rishitha S, Divyanjali M, Amzad SK, Anu B, Girish C, Apparao CH   +6 more
openaire   +2 more sources

Polymeric and Lipid Nanoparticles: Which Applications in Pediatrics?

Pharmaceutics, 2021
This review aims to provide the state of the art on polymeric and lipid nanoparticles, used or suggested to approach pediatric diseases’ problems and needs, and to inspire new researches in this field.
Noelia Nieto González, Antonella Obinu, Giovanna Rassu, Paolo Giunchedi, Elisabetta Gavini   +4 more
doaj   +1 more source

Nanoporous silica-based protocells at multiple scales for designs of life and nanomedicine. [PDF]

, 2015
Various protocell models have been constructed de novo with the bottom-up approach. Here we describe a silica-based protocell composed of a nanoporous amorphous silica core encapsulated within a lipid bilayer built by self-assembly that provides for ...
Brinker, C Jeffrey, Jakobsson, Eric, Sun, Jie, Wang, Yingxiao   +3 more
core   +2 more sources

Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery.

Journal of Controlled Release, 2021
Therapeutic mRNA has the potential to revolutionize the treatment of myriad diseases and, in 2020, facilitated the most rapid vaccine development in history.
Jilian R. Melamed, Khalid A. Hajj, Namit Chaudhary, Daria Strelkova, Mariah L. Arral, N. Pardi, M. Alameh, Jason B Miller, L. Farbiak, D. Siegwart, D. Weissman, K. Whitehead   +11 more
semanticscholar   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Delivery of Oligonucleotides Using a Self-Degradable Lipid-Like Material

Pharmaceutics, 2021
The world-first success of lipid nanoparticle (LNP)-based siRNA therapeutics (ONPATTRO®) promises to accelerate developments in siRNA therapeutics/gene therapy using LNP-type drug delivery systems (DDS).
Hiroki Tanaka, Nae Takata, Yu Sakurai, Tokuyuki Yoshida, Takao Inoue, Shinya Tamagawa, Yuta Nakai, Kota Tange, Hiroki Yoshioka, Masatoshi Maeki, Manabu Tokeshi, Hidetaka Akita   +11 more
doaj   +1 more source

Mechanism of cellular uptake of genotoxic silica nanoparticles. [PDF]

, 2012
Mechanisms for cellular uptake of nanoparticles have important implications for nanoparticulate drug delivery and toxicity. We have explored the mechanism of uptake of amorphous silica nanoparticles of 14 nm diameter, which agglomerate in culture medium ...
Brown, AP, Hondow, NS, Jeuken, LJ, Krzemiński, L, Mu, Q, Routledge, MN   +5 more
core   +3 more sources

Roles of reconstituted high-density lipoprotein nanoparticles in cardiovascular disease: A new paradigm for drug discovery [PDF]

, 2020
Epidemiological results revealed that there is an inverse correlation between high-density lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease (ASCVD).
Huang, Hui, Huang, Jiansheng, Huang, Li-Hao, Wang, Dongdong   +3 more
core   +2 more sources

The Future of Tissue-Targeted Lipid Nanoparticle-Mediated Nucleic Acid Delivery

Pharmaceuticals, 2022
The earliest example of in vivo expression of exogenous mRNA is by direct intramuscular injection in mice without the aid of a delivery vehicle. The current state of the art for therapeutic nucleic acid delivery is lipid nanoparticles (LNP), which are ...
Ruvanthi N Kularatne, Rachael M. Crist, S. Stern   +2 more
semanticscholar   +1 more source