Results 71 to 80 of about 88,630 (306)

Lipid nanoparticle of tobramycin [PDF]

, 2014
[ES] La presente invención se relaciona con una nanopartícula lipídica que comprende al menos un antibiótico tobramicina, una fracción lipídica y uno o más tensioactivos, y el uso de la nanopartícula en la prevención y/o tratamiento de infecciones del ...
Pozo, Ángel del, Pastor Navarro, Marta, Esquisabel Alegría, Amaia, Ibarrola Moreno, Oihane, Moreno-Sastre, María, Herrán Martínez, Enara, Gainza Lucea, Garazi, Vinuesa Aumedes, María Teresa, Gainza Lafuente, Eusebio, Viñas Ciordia, Miguel, Bachiller, Daniel, Villullas Rincón, Silvia, Pedraz Muñoz, José Luis, Aguirre Anda, José Javier   +13 more
core  

Optimization of ionizable lipids for aerosolizable mRNA lipid nanoparticles

Bioengineering & Translational Medicine, 2023
Although mRNA lipid nanoparticles (LNPs) are highly effective as vaccines, their efficacy for pulmonary delivery has not yet fully been established. A major barrier to this therapeutic goal is their instability during aerosolization for local delivery ...
Mae M. Lewis, Melissa R. Soto, Esther Y. Maier, Steven D. Wulfe, Sandy Bakheet, Hannah Obregon, Debadyuti Ghosh   +6 more
doaj   +1 more source

MXene Wrapped Magnetic Mesocrystals for Durable Redox Catalytic Cancer Therapy and Responsive MRI

Advanced Functional Materials, EarlyView.
Conformal wrapping of ultrathin Ti3C2Tx MXene nanosheets on Fe3O4 mesocrystals creates topology‐stabilized Schottky junctions that direct photoinduced electron transfer under NIR irradiation. The unique architecture sustains Fenton catalysis, promotes continuous hydroxyl radical production, and provides photo‐responsive MRI contrast.
Min Jun Ko, Seongchan Kim, Jun‐Hyeok Han, Sanghee Lee, Minji Ahn, Hong En Fu, Young Jun Jang, Yoo Sang Jeon, Weiguo Li, Young Keun Kim, Dong‐Hyun Kim   +10 more
wiley   +1 more source

The Use of Computational Approaches to Design Nanodelivery Systems

Nanomaterials
Nano-based drug delivery systems present a promising approach to improve the efficacy and safety of therapeutics by enabling targeted drug transport and controlled release.
Abedalrahman Abughalia, Mairead Flynn, Paul F. A. Clarke, Darren Fayne, Oliviero L. Gobbo   +4 more
doaj   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Lipid-based nanoparticles as drug delivery carriers for cancer therapy

Frontiers in Oncology
Cancer is a severe disease that results in death in all countries of the world. A nano-based drug delivery approach is the best alternative, directly targeting cancer tumor cells with improved drug cellular uptake.
Ibtesam Waheed, Anwar Ali, Anwar Ali, Huma Tabassum, Narjis Khatoon, Wing-Fu Lai, Wing-Fu Lai, Xin Zhou   +7 more
doaj   +1 more source

Transferrin-Decorated Protein-Lipid Hybrid Nanoparticle Efficiently Delivers Cisplatin and Docetaxel for Targeted Lung Cancer Treatment

Drug Design, Development and Therapy, 2021
Kaiping Mao,1 Weina Zhang,2 Lan Yu,3 Yi Yu,1 Haixia Liu,1 Xiaotao Zhang3 1Department of Thoracic surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People’s Republic of China; 2Department of Plastic surgery, The Affiliated Hospital ...
Mao K, Zhang W, Yu L, Yu Y, Liu H, Zhang X   +5 more
doaj  

One‐Step Microfluidic Manufactured Fucose‐Decorated Sweetosomes Choose the Time and the Road for Their Intracellular Journey to Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Sweetosomes, a new class of fucose‐decorated liposomes, are developed via a one‐step microfluidic process without surface chemistry. This study elucidates their main caveolae‐mediated entry and distinct endosomal trafficking. These nanostructures demonstrate superior endosomal escape, organelle acidity modulation, and prolonged plasma persistence ...
Mattia Tiboni, Mariele Montanari, Shiva Khorshid, Michele Verboni, Andrea Duranti, Simone Lucarini, Daniele Lopez, Annalisa Aluigi, Gianluca Morganti, Michele Menotta, Giovanna Panza, Daniel J. Klionsky, Barbara Canonico, Luca Casettari   +13 more
wiley   +1 more source

Enhanced permeability of blood–brain barrier and targeting function of brain via borneol-modified chemically solid lipid nanoparticle

International Journal of Nanomedicine, 2018
Hui Song, Man Wei, Nan Zhang, He Li, Xiaochuan Tan, Yujia Zhang, Wensheng Zheng Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College ...
Song H, Wei M, Zhang N, Li H, Tan XC, Zhang YJ, Zheng WS   +6 more
doaj  

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source