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iScience, 2021 Summary Vaccines based on mRNA-containing lipid nanoparticles (LNPs) are a promising new platform used by two leading vaccines against COVID-19. Clinical trials and ongoing vaccinations present with varying degrees of protection levels and side effects ...
Sonia Ndeupen +5 more
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Biophysical analysis of lipidic nanoparticles [PDF]
Methods, 2020 Biological nanoparticles include liposomes, extracellular vesicle and lipid-based discoidal systems. When studying such particles, there are several key parameters of interest, including particle size and concentration. Measuring these characteristics can be of particular importance in the research laboratory or when producing such particles as ...
Rozo, Annaïg J. +4 more
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Lipid nanoparticle-based mRNA vaccines in cancers: Current advances and future prospects
Frontiers in Immunology, 2022 Messenger RNA (mRNA) vaccines constitute an emerging therapeutic method with the advantages of high safety and efficiency as well as easy synthesis; thus, they have been widely used in various human diseases, especially in malignant cancers. However, the
Tao Huang +6 more
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A correlative model to predict in vivo AUC for nanosystem drug delivery with release rate-limited absorption [PDF]
, 2012 Purpose. Drug release from nanosystems at the sites of either absorption or effect biophase is a major determinant of its biological action. Thus, in vitro drug release is of paramount importance in gaining insight for the systems performance in vivo ...
Adibkia, Khosro +6 more
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International Journal of Molecular Sciences, 2022 PEGylated lipids are one of the four constituents of lipid nanoparticle mRNA COVID-19 vaccines. Therefore, various concerns have been raised on the generation of anti-PEG antibodies and their potential role in inducing hypersensitivity reactions ...
G. Guerrini +8 more
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Lipid Nanoparticles for Ocular Gene Delivery
Journal of Functional Biomaterials, 2015 Lipids contain hydrocarbons and are the building blocks of cells. Lipids can naturally form themselves into nano-films and nano-structures, micelles, reverse micelles, and liposomes.
Yuhong Wang +2 more
doaj +1 more source
The role of surface charge in the interaction of nanoparticles with model pulmonary surfactants [PDF]
, 2018 Inhaled nanoparticles traveling through the airways are able to reach the respiratory zone of the lungs. In such event, the incoming particles first enter in contact with the liquid lining the alveolar epithelium, the pulmonary surfactant.
Berret, J. -F., Mousseau, F.
core +4 more sources
Xylem surfactants introduce a new element to the cohesion-tension theory [PDF]
, 2016 Vascular plants transport water under negative pressure without constantly creating gas bubbles that would disable their hydraulic systems. Attempts to replicate this feat in artificial systems almost invariably result in bubble formation, except under ...
Do, Aissa YT +10 more
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mRNA lipid nanoparticle phase transition
Biophysical Journal, 2022 Crucial for mRNA-based vaccines are the composition, structure, and properties of lipid nanoparticles (LNPs) as their delivery vehicle. Using all-atom molecular dynamics simulations as a computational microscope, we provide an atomistic view of the structure of the Comirnaty vaccine LNP, its molecular organization, physicochemical properties, and ...
Trollmann, Marius F.W. +1 more
openaire +2 more sources
Lipid-Nanoparticle-Based Delivery of CRISPR/Cas9 Genome-Editing Components
Molecular Pharmaceutics, 2022 Gene editing mediated by CRISPR/Cas9 systems is due to become a beneficial therapeutic option for treating genetic diseases and some cancers. However, there are challenges in delivering CRISPR components which necessitate sophisticated delivery systems ...
Pardis Kazemian +5 more
semanticscholar +1 more source