Results 31 to 40 of about 2,353,041 (346)

Improved Bioavailability of Poorly Soluble Drugs through Gastrointestinal Muco-Adhesion of Lipid Nanoparticles

Pharmaceutics, 2021
Gastrointestinal absorption remains indispensable in the systemic delivery of most drugs, even though it presents several challenges that, paradoxically, may also provide opportunities that can be exploited to achieve maximal bioavailability.
Sui Ling Janet Tan, Nashiru Billa
doaj   +1 more source

Native silica nanoparticles are powerful membrane disruptors [PDF]

, 2015
Silica nanoparticles are under development for intracellular drug delivery applications but can also have cytotoxic effects including cell membrane damage.
Alkhammash, Hend I., Berthier, Rémy, de Planque, Maurits R.R., Li, Nan   +3 more
core   +1 more source

Recent Advances in the Lipid Nanoparticle-Mediated Delivery of mRNA Vaccines

Vaccines, 2023
Lipid nanoparticles (LNPs) have recently emerged as one of the most advanced technologies for the highly efficient in vivo delivery of exogenous mRNA, particularly for COVID-19 vaccine delivery.
K. Swetha, Niranjan G. Kotla, Lakshmi Tunki, Arya Jayaraj, S. Bhargava, Haitao Hu, Srinivisa Reddy Bonam, Rajendra Kurapati   +7 more
semanticscholar   +1 more source

Hydrophobic silver nanoparticles trapped in lipid bilayers: Size distribution, bilayer phase behavior, and optical properties

Journal of Nanobiotechnology, 2008
Background Lipid-based dispersion of nanoparticles provides a biologically inspired route to designing therapeutic agents and a means of reducing nanoparticle toxicity.
Bothun Geoffrey D
doaj   +1 more source

Macrophage-Targeted Lipid Nanoparticle Delivery of microRNA-146a to Mitigate Hemorrhagic Shock-Induced Acute Respiratory Distress Syndrome.

ACS Nano, 2023
The pro-inflammatory response of alveolar macrophages to injurious physical forces during mechanical ventilation is regulated by the anti-inflammatory microRNA, miR-146a.
Q. Fei, E. Shalosky, R. Barnes, V. Shukla, Siying Xu, M. Ballinger, L. Farkas, Robert J. Lee, S. Ghadiali, J. Englert   +9 more
semanticscholar   +1 more source

Lipid nanoparticles with ionizable lipids: Statistical aspects

Physical Review E, 2022
Lipid nanoparticles (LNPs) with size ∼100 nm are now used for fabrication of a new generation of drugs and antiviral vaccines. To optimize their function or, more specifically, interaction with cell membranes, their composition often includes ionizable lipids which are neutral or cationic (after association with H^{+}).
openaire   +2 more sources

Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization

Pharmaceutics, 2020
Background: Capsaicin (CPS) is a highly selective agonist of the transient receptor potential vanilloid type 1 (TRPV1) with a nanomolar affinity. High doses or prolonged exposure to CPS induces TRPV1 defunctionalization and, although this effect is ...
Carmelo Puglia, Debora Santonocito, Angela Bonaccorso, Teresa Musumeci, Barbara Ruozi, Rosario Pignatello, Claudia Carbone, Carmela Parenti, Santina Chiechio   +8 more
doaj   +1 more source

Higher or Lower? - The Resolution of Analytical Pipelines for the Evaluation of Lipid Nanoparticle Critical Quality Attributes

British Journal of Pharmacy, 2023
Dynamic light scattering (DLS) is a routinely used analytical technique to measure the size distribution of a colloidal sample. Nanoparticle tracking analysis (NTA) has more recently emerged as an orthogonal technique to determine particle size and ...
Callum George Davidson, Rand Abdulrahman, Michael Cairns, Yvonne Perrie , Zahra Rattray   +4 more
doaj   +1 more source

Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2

bioRxiv, 2022
Advanced mRNA vaccines play vital roles against SARS-CoV-2. However, most current mRNA delivery platforms need to be stored at −20 °C or −70 °C due to their poor stability, which severely restricts their availability.
Liangxia Ai, Yafei Li, Li Zhou, Wenrong Yao, Hao Zhang, Zhaoyu Hu, Jinyu Han, Weijie Wang, Jun Wu, Pan Xu, Ruiyue Wang, Zhan-Fei Li, Zhouwang Li, Cheng-Bin Wei, Jianqun Liang, Haobo Chen, Zhimiao Yang, M. Guo, Zhi-xiang Huang, Xin Wang, Zhen Zhang, Wenjie Xiang, Dazheng Sun, Lianqiang Xu, Meiyan Huang, Bin Lv, Peiqi Peng, Shangfeng Zhang, Xuhao Ji, Huiyi Luo, Nan Chen, Jianping Chen, K. Lan, Yong Hu   +33 more
semanticscholar   +1 more source

Remotely Controlled Diffusion from Magnetic Liposome Microgels [PDF]

, 2013
The reversible, temperature-dependent change in the permeability of a phospholipid bilayer has been used for controlling the diffusion rate of encapsulated molecular payload from liposomes.
Dohnal, Jiří, Hanuš, Jaroslav, Singh, Mandeep, Ullrich, Martin, Štěpánek, František   +4 more
core   +1 more source