Results 11 to 20 of about 2,353,041 (346)
Advanced Materials, 2023 The transfection potency of lipid nanoparticle (LNP) mRNA systems is critically dependent on the ionizable cationic lipid component. LNP mRNA systems composed of optimized ionizable lipids often display distinctive mRNA‐rich “bleb” structures.
Miffy H Y Cheng +12 more
semanticscholar +3 more sources
Lipid nanoparticles for mRNA delivery [PDF]
Nature Reviews Materials, 2021 Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent and treat various diseases. To function in vivo, mRNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow cellular uptake and mRNA release.
Xucheng Hou +3 more
openaire +4 more sources
Lipid Nanoparticle Systems for Enabling Gene Therapies.
Molecular Therapy, 2017 Genetic drugs such as small interfering RNA (siRNA), mRNA, or plasmid DNA provide potential gene therapies to treat most diseases by silencing pathological genes, expressing therapeutic proteins, or through gene-editing applications. In order for genetic
P. Cullis, M. Hope
semanticscholar +3 more sources
Blood Distribution of SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine in Humans
ACS NanoLipid nanoparticle mRNA vaccines are an exciting but new technology used in humans. There is limited understanding of factors that influence their biodistribution and immunogenicity. Antibodies to polyethylene glycol (PEG), which is on the surface of the
S. Kent +13 more
semanticscholar +3 more sources
PEGylated Lipid Nanoparticle Formulations: Immunological Safety and Efficiency Perspective
Bioconjugate chemistry, 2023 Lipid nanoparticles (LNPs) have been recognized as efficient vehicles to transport a large variety of therapeutics. Currently in the spotlight as important constituents of the COVID-19 mRNA vaccines, LNPs play a significant role in protecting and ...
Rumiana Tenchov, Janet M. Sasso, Q. Zhou
semanticscholar +1 more source
Nanoparticles-cell association predicted by protein corona fingerprints [PDF]
, 2016 In a physiological environment (e.g., blood and interstitial fluids) nanoparticles (NPs) will bind proteins shaping a "protein corona" layer. The long-lived protein layer tightly bound to the NP surface is referred to as the hard corona (HC) and encodes ...
Caracciolo, Giulio +6 more
core +3 more sources
Molecular Therapy, 2022 Lipid nanoparticle (LNP)-formulated nucleoside-modified mRNA vaccines have proven to be very successful in the fight against the coronavirus disease 2019 (COVID-19) pandemic. They are effective, safe, and can be produced in large quantities. However, the
Hiromi Muramatsu +9 more
semanticscholar +1 more source
Computer Simulations of Lipid Nanoparticles [PDF]
Nanomaterials, 2017 Lipid nanoparticles (LNP) are promising soft matter nanomaterials for drug delivery applications. In spite of their interest, little is known about the supramolecular organization of the components of these self-assembled nanoparticles. Here, we present a molecular dynamics simulation study, employing the Martini coarse-grain forcefield, of self ...
Xavier Fernandez-Luengo +2 more
openaire +5 more sources
LIPID AND SILVER NANOPARTICLES GELS FORMULATION OF TEMPEH EXTRACT
Jurnal Farmasi Sains dan Komunitas, 2020 Tempeh extract is used in this study as an active ingredient in lipid nanoparticles and reductant in silver nanoparticles because tempeh is an authentic Indonesian food ingredient and is known to have the main content of isoflavones.
Felicia Satya Christania +2 more
doaj +1 more source
Nature Communications, 2023 In terms of lipid nanoparticle (LNP) engineering, the relationship between particle composition, delivery efficacy, and the composition of the biocoronas that form around LNPs, is poorly understood.
Kai Liu +11 more
semanticscholar +1 more source