Results 111 to 120 of about 88,630 (306)

From Lab to Landscape: Environmental Biohybrid Robotics for Ecological Futures

Advanced Robotics Research, EarlyView.
This Perspective explores environmental biohybrid robotics, integrating living tissues, microorganisms, and insects for operation in real‐world ecosystems. It traces the leap from laboratory experiments to forests, wetlands, and urban environments and discusses key challenges, development pathways, and opportunities for ecological monitoring and ...
Miriam Filippi
wiley   +1 more source

Lipid implants for controlled release of proteins

, 2007
In recent years, we have seen significant progress towards understanding the role of proteins in both physiological and pathological processes. Especially neurotrophic factors have increasingly come into focus for the treatment of neurodegenerative ...
Könnings, Stephanie
core   +1 more source

Low-Cost Microfluidic Mixers: Are They up to the Task?

Pharmaceutics
Background/Objectives: Microfluidic mixing has become the gold standard procedure for manufacturing nucleic acid lipid-based delivery systems, offering precise control over critical process parameters.
Jade Forrester, Callum G. Davidson, May Blair, Lynn Donlon, Daragh M. McLoughlin, Chukwuebuka R. Obiora, Heather Stockdale, Ben Thomas, Martina Nutman, Sarah Brockbank, Zahra Rattray, Yvonne Perrie   +11 more
doaj   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Development and Optimization of Solid Lipid Nanoparticle for Topical Delivery

, 2019
The aim of present work was to develop and evaluate solid lipid nanoparticle (SLNs) based gel for topical delivery of anti-inflammatory drug. Material and method Nabumetone loaded SLNs were developed by hot homogenization followed by ultra- sonication ...
Ghodake, Mahananda.V, Chaudhari, Pallavi M   +1 more
core   +1 more source

siRNA/CS‐PLGA Nanoparticle System Targeting Knockdown Intestinal SOAT2 Reduced Intestinal Lipid Uptake and Alleviated Obesity

Advanced Science
Effective inhibition of intestinal lipid uptake is an efficient strategy for the treatment of disorders related to lipid metabolism. Sterol O‐acyltransferase 2 (SOAT2) is responsible for the esterification of free cholesterol and fatty acids into ...
Jingjia Liang, Wentao Shao, Pu Ni, Qian Liu, Weirui Kong, Weiyi Shen, Qihan Wang, Anhua Huang, Guixin Zhang, Yulong Yang, Hongliang Xin, Zhaoyan Jiang, Aihua Gu   +12 more
doaj   +1 more source

C24 Ceramide Lipid Nanoparticles for Skin Wound Healing

Pharmaceutics
Background/Objectives: C24 ceramide plays a crucial role in skin regeneration and wound healing; however, its hydrophobic nature limits its application in therapeutic formulations.
Ji-Hye Lee, Jin-Hyun Kim, Tong-Il Hyeon, Khee-Tae Min, Se-Young Lee, Han-Chul Ko, Hong-Seok Choi, Kuk-Youn Ju, Young-Seok Cho, Tae-Jong Yoon   +9 more
doaj   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Structural and functional glycosphingolipidomics by glycoblotting with aminooxy-functionalized gold nanoparticle

, 2008
Glycosphingolipids (GSLs) synthesized in Golgi apparatus by sequential transfer of sugar residues to a ceramide lipid anchor are ubiquitously distributing on vertebrate plasma membranes.
Midori Abe, Noriko Nagahori, Shin-Ichiro Nishimura   +2 more
core  

N, S Co‐Doped Carbon Quantum Dots‐Riboflavin Composite Photosensitizers for Enhanced Iontophoresis‐Assisted Corneal Cross‐Linking

Advanced Science, EarlyView.
This study explores the use of N, S co‐doped carbon quantum dots (NS‐CQDs) as carriers for riboflavin, creating NS‐CQDs‐RF composite photosensitizers. These composites improve riboflavin absorption, enhance ROS generation efficiency, and preserve corneal epithelium integrity.
Tinghong Xu, Yong Liu, Wenjing Zhang, Qiuruo Jiang, Yi Jin, Liangzheng Lin, Lumeng Wang, Zhanhao Gu, Mimi Lin, Shihao Chen   +9 more
wiley   +1 more source