Results 111 to 120 of about 2,353,041 (346)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

2014 REU Poster: Quantifying Lipid Contents In Liposomes with Enveloped Plasmonic Nanoparticles [PDF]

, 2014
Poster presentation at REU Summer's End Research Symposium, 2014, by REU participant Beatrix Seytono, Calhoun Community College - Bjoern Reinhard group, Amin Feizpour lab mentor.Phosphatidylserine(PS) and monosialotetrahexosylganglioside(GM1) are ...
Seytono, Beatrix
core   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Investigations Into the Influence of Ionizable Lipids on the Stability of Lipid Nanoparticle

MedComm – Biomaterials and Applications
Messenger RNA‐loaded lipid nanoparticles (mRNA@LNPs) have achieved remarkable success in vaccine development, but their long‐term preservation imposes stringent requirements for transportation and storage. To broaden application of this technology, it is
Jie Wang, Zhitong Guo, Jun Yang, Haiyin Yang, Shaoping Jiang, Abid Naeem, Bo Hu, Yuhua Weng, Yuanyu Huang   +8 more
doaj   +1 more source

Simple Scattering: Lipid nanoparticle structural data repository

Frontiers in Molecular Biosciences
Lipid nanoparticles (LNPs) are being intensively researched and developed to leverage their ability to safely and effectively deliver therapeutics.
Lee Joon Kim, David Shin, Wellington C. Leite, Hugh O’Neill, Oliver Ruebel, Andrew Tritt, Greg L. Hura, Greg L. Hura   +7 more
doaj   +1 more source

Plasmonic antennas and zero mode waveguides to enhance single molecule fluorescence detection and fluorescence correlation spectroscopy towards physiological concentrations

, 2014
Single-molecule approaches to biology offer a powerful new vision to elucidate the mechanisms that underpin the functioning of living cells. However, conventional optical single molecule spectroscopy techniques such as F\"orster fluorescence resonance ...
de Torres, Juan, Ghenuche, Petru, Grigoriev, Victor, Moparthi, Satish Babu, Punj, Deep, Rigneault, Hervé, Wenger, Jérôme   +6 more
core   +3 more sources

Unleashing the Power of Machine Learning in Nanomedicine Formulation Development

Advanced Functional Materials, EarlyView.
A random forest machine learning model is able to make predictions on nanoparticle attributes of different nanomedicines (i.e. lipid nanoparticles, liposomes, or PLGA nanoparticles) based on microfluidic formulation parameters. Machine learning models are based on a database of nanoparticle formulations, and models are able to generate unique solutions
Thomas L. Moore, Cristiano Pesce, Antonietta Greco, Claudia Pisante, Greta Avancini, Valentina Di Francesco, Yosi Shamay, Paolo Decuzzi   +7 more
wiley   +1 more source

The Use of Computational Approaches to Design Nanodelivery Systems

Nanomaterials
Nano-based drug delivery systems present a promising approach to improve the efficacy and safety of therapeutics by enabling targeted drug transport and controlled release.
Abedalrahman Abughalia, Mairead Flynn, Paul F. A. Clarke, Darren Fayne, Oliviero L. Gobbo   +4 more
doaj   +1 more source

Optimization of ionizable lipids for aerosolizable mRNA lipid nanoparticles

Bioengineering & Translational Medicine, 2023
Although mRNA lipid nanoparticles (LNPs) are highly effective as vaccines, their efficacy for pulmonary delivery has not yet fully been established. A major barrier to this therapeutic goal is their instability during aerosolization for local delivery ...
Mae M. Lewis, Melissa R. Soto, Esther Y. Maier, Steven D. Wulfe, Sandy Bakheet, Hannah Obregon, Debadyuti Ghosh   +6 more
doaj   +1 more source

Dimensionality of Carbon Nanomaterials Determines the Binding and Dynamics of Amyloidogenic Peptides: Multiscale Theoretical Simulations [PDF]

, 2013
Experimental studies have demonstrated that nanoparticles can affect the rate of protein self-assembly, possibly interfering with the development of protein misfolding diseases such as Alzheimer's, Parkinson's and prion disease caused by aggregation and ...
A Albanese, A de Leon, A Gajewicz, A Hung, A Hung, A Hung, A Hung, A Hung, AA Mostofi, AA Shvedova, Ad Leon, Adam J. Makarucha, AJ Makarucha, AK Chamberlain, Arash A. Mostofi, AV Ghule, B Hess, B Roux, C Cabaleiro-Lago, C Li, C-K Skylaris, CA MacRaild, CA MacRaild, CC Chiu, CC Chiu, CK Skylaris, CK Skylaris, CL Teoh, D Frishman, D Van Der Spoel, DJ Cole, DM Hatters, EE Oren, G Lever, G Zuo, G Zuo, G Zuo, GB McGaughey, H Li, HC Fischer, HJC Berendsen, Irene Yarovsky, J Antony, J Dziedzic, J Kayat, J Lee, James M. Briggs, JP Perdew, JP Segrest, LJ Liang, LK Vesterdal, LM Wilson, LP Lee, M Mahmoudi, M Mahmoudi, M van der Zande, M Zhang, M Zhu, MDW Griffin, MP Monopoli, N Todorova, N Todorova, N Todorova, NDM Hine, Nevena Todorova, Nicholas D. M. Hine, Q Hill, Q Sun, R Cukalevski, R de la Rica, R Mout, RS D'Rozario, S De Miranda Tomásio, S Ehrlich, S Linse, SA Andujar, SA Love, SM Tomasio, ST Yang, TE Cheatham, TR Walsh, VC Sanchez, VL Colvin, VZ Poenitzsch, W Humphrey, WH Noon, Z Fu, Z Li, Z Yang   +88 more
core   +4 more sources