Results 121 to 130 of about 88,630 (306)

TET1-Lipid Nanoparticle Encapsulating Morphine for Specific Targeting of Peripheral Nerve for Pain Alleviation

Hongmei Yang,1,* Zhongqi Liu,1,* Fan Liu,1,2,* Haixuan Wu,1 Xiaoyan Huang,1 Rong Huang,1 Phei Er Saw,3,4 Minghui Cao1,2 1Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic
Yang H, Liu Z, Saw PE, Cao M, Huang X, Huang R, Liu F, Wu H   +7 more
core  

Multifunctional Nanoparticle/Lipid Self-Assemblies

, 2008
Lipid bilayer membranes provide the physical barriers that define the structure, function, and stability of living cells. Specifically, they play a key role in governing molecular and phase toxicity, anesthetic action, the bioaccumulation of hydrophobic ...
Bothun, Geoff
core  

Therapeutic potential of ISG20 in attenuating podocyte injury via inhibition of ferroptosis

Molecular Therapy: Nucleic Acids
Ferroptosis, an iron-dependent form of cell death characterized by lipid peroxidation, has been recognized as a critical mechanism contributing to podocyte injury in diabetic kidney disease (DKD).
Di Zhou, Xinyi Chen, Meng Jia, Xiaoxiao Liu, Lingzhi Huang, Yongsheng Xie, Liang Li, Yi Fu, Yubin Feng, Zhaoyi Yang, Liqin Tang   +10 more
doaj   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Serum heat inactivation diminishes ApoE-mediated uptake of D-Lin-MC3-DMA lipid nanoparticles

Beilstein Journal of Nanotechnology
Nanoparticles play a crucial role in drug delivery research. The protein corona that develops on the surface of nanoparticles after administration has garnered substantial attention due to the significant effects it has on their performance.
Demian van Straten, Luuk van de Schepop, Rowan Frunt, Pieter Vader, Raymond M. Schiffelers   +4 more
doaj   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

PRELIMINARY STUDY ON THE IMPACT OF POLYMER-LIPID TYPES AND RATIO TO POLYMERIC-LIPID HYBRID NANOPARTICLE

, 2021
Objective: This study aims to determine the best lipid to polymer ratios in polymeric-lipid nanoparticles using various types and ratios of polymers and lipids.
FADHILLA, AVIOLA, PUTRI, MONICA ANDIKA, PUSPITA, OKTAVIA EKA, WIDODO, FERRI, ROSSARIZA, ISWA, SARI, NI PUTU JUNITA   +5 more
core  

The combination of rAAV pseudo-lipid nanoparticle and triamcinolone acetonide enables multi-administration to liver

Molecular Therapy: Methods & Clinical Development
The multi-administration of recombinant adeno-associated virus (rAAV) is limited largely by immunological barriers. Herein, a novel strategy, named rAAV pseudo-lipid nanoparticle combined with triamcinolone acetonide (LNP-rAAV + TAC), has been described ...
Chunmei Gan, Mi Leng, Yu Liu, Zhaoyue Zheng, Siwu He, Wen Qiao, Lin Xiao, Yao Xiao, Jingya Ye, Lixing Zhou, Jiao Zhou, Boduan Xiao, Wenxin Zhao, Jiamei Yang, Aohan Wu, Huiyuan Zhang, Hongbo Hu, Xiaobo Cen, Zhiyong Qian, Haohao Dong, C. Alexander Valencia, Lunzhi Dai, Hoi Yee Chow, Lei Zhang, Biao Dong   +24 more
doaj   +1 more source

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source