Results 141 to 150 of about 88,630 (306)

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Transdermal permeability of triamcinolone acetonide lipid nanoparticles

, 2019
Zhenmiao Qin,1 Feng Chen,1,2 Demei Chen,1 Yong Wang,1,2 Yinfeng Tan,1,2 Junfeng Ban3 1School of Pharmacy, Hainan Medical University, Haikou, People’s Republic of China; 2Hainan Provincial Key Laboratory of R&D of Tropical Herbs, Hainan Medical
Chen DM, Ban JF, Chen F, Wang Y, Tan YF, Qin ZM   +5 more
core  

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Corneal permeation properties of a charged lipid nanoparticle carrier containing dexamethasone

, 2017
Junfeng Ban, Yan Zhang, Xin Huang, Guanghan Deng, Dongzhi Hou, Yanzhong Chen, Zhufen Lu Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China Abstract ...
Ban J, Zhang Y, Hou DZ, Huang X, Lu ZF, Chen YZ, Deng GH   +6 more
core  

Lipid-Based Nanoparticles

Journal of Innovations in Applied Pharmaceutical Science (JIAPS)
Lipid-based nanoparticles (LNPs) are nano-sized particles composed of lipids, which are natural or synthetic molecules. It comprises of phospholipid bilayer in its structure. The unique properties of lipids such as biocompatibility and versatility, have spurred the development of various lipid based nano formulations.
Sindhu Gillella, Rishitha S, Divyanjali M, Amzad SK, Anu B, Girish C, Apparao CH   +6 more
openaire   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Ionizable Lipid Nanoparticle-Mediated TRAIL mRNA Delivery in the Tumor Microenvironment to Inhibit Colon Cancer Progression

Walison Nunes da Silva,1 Pedro Augusto Carvalho Costa,1 Sérgio Ricardo Aluotto Scalzo Júnior,1 Heloísa AS Ferreira,1 Pedro Henrique Dias Moura Prazeres,2 Caroline Leonel Vasconcelos Campos,3 Marco Túllio Rodrigues Alves,1 Natália Jordana Alves da Silva,1
de Castro Santos AL, Bicalho KA, Ferreira HAS, Santiago HDC, Lobo AO, Ferris MEC, da Silva WN, Vasconcelos Costa V, da Silva Barcelos L, Alves da Silva NJ, Guimarães LC, Pires Goulart Guimaraes P, Thatte A, Rodrigues Alves MT, Mitchell MJ, Teixeira MM, Carvalho Costa PA, Figueiredo MM, Hamilton A, Campos CLV, Scalzo Júnior SRA, Prazeres PHDM, Frézard F   +22 more
core  

Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids

Advanced Science, EarlyView.
Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan, Xuelin Wang, Zhongyao Chen, Shuo Wang, Weining Gao, Ziyi Chen, Runyang Li, Cheng Hao, Lei Zhang, Qiongqiong Zhang, Ke Zhang, Mei Yu, Qian Liu, Jingxuan Wang, Huiping Li, Simpkins Fiona, Jing Liu, Qiang Liu, Peng Liu, Yawei Hu   +19 more
wiley   +1 more source

Avaliação toxicológica de nanopartículas compostas de dióxido de titânio, superparamagnéticas de óxido de ferro e de poliuretano in vitro, in vivo, ex vivo e in silico [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2015.A nanotecnologia envolve a compreensão e manipulação da matéria em escala nanométrica, em que os ...
Silva, Adny Henrique
core  

A novel therapeutic strategy for cartilage diseases based on lipid nanoparticle-RNAi delivery system

International Journal of Nanomedicine, 2018
Shaowei Wang,1 Xiaochun Wei,1 Xiaojuan Sun,1 Chongwei Chen,1 Jingming Zhou,2 Ge Zhang,3 Heng Wu,3 Baosheng Guo,3 Lei Wei1,2 1Department of Orthopaedics, The 2nd Hospital of Shanxi Medical University, Taiyuan, Shanxi, China; 2Department of Orthopaedics ...
Wang S, Wei X, Sun X, Chen C, Zhou J, Zhang G, Wu H, Guo B, Wei L   +8 more
doaj