Results 91 to 100 of about 15,472 (293)

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Modulating the Nature of Ionizable Lipids and Number of Layers in Hyaluronan-Decorated Lipid Nanoparticles for In Vitro Delivery of RNAi

Pharmaceutics
Lipid nanoparticles (LNPs) have established their position as nonviral vectors for gene therapy. Tremendous efforts have been made to modulate the properties of LNPs to unleash their full clinical potential.
Victor Passos Gibson, Houda Tahiri, Claudia Gilbert, Chun Yang, Quoc Thang Phan, Xavier Banquy, Pierre Hardy   +6 more
doaj   +1 more source

Comparison of lipid membrane-water partitioning with various organic solvent-water partitions of neutral species and ionic species: Uniqueness of cerasome as a model for the stratum corneum in partition processes [PDF]

, 2015
YesLipid membrane-water partitions (e.g., immobilized artificial membrane systems where the lipid membrane is a neutral phospholipid monolayer bound to gel beads) were compared to various organic solvent-water partitions using linear free energy ...
Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Abraham, Alfred Fahr, Austin, Avdeef, Balon, Balon, Bano, Beigi, Carrozzino, Collander, Desmond J. Tobin, Finkelstein, Fruttero, Ishihama, Keda Zhang, Leo, Liu, Liu, Lukacova, Mason, Meindl, Michael H. Abraham, Moore, Ong, Ong, Osterberg, Pauletti, Pidgeon, Rand, Sarmento, Tejwani, Wiedmer, Wiedmer, William E. Acree, Xiang, Xiangli Liu, Zhang, Zhang   +49 more
core   +1 more source

Optimization of lipid nanoparticles loaded with ribonucleoprotein-oligonucleotide complexes for in vivo delivery of a CRISPR/Cas9 system targeting hepatitis B virus

Virus Research
Patients with chronic hepatitis B virus (HBV) infection may benefit from clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9)-based gene therapy. We previously identified a guide RNA (WJ11) that suppressed
Rupaly Akhter, Bouchra Kitab, Mohammad Enamul Hoque Kayesh, Rina Shimizu, Haruno Onuma, Naoki Yamamoto, Shintaro Ogawa, Masaya Sugiyama, Yasuhito Tanaka, Yusuke Sato, Michinori Kohara, Kyoko Tsukiyama-Kohara   +11 more
doaj   +1 more source

Charged Membranes: Poisson-Boltzmann theory, DLVO paradigm and beyond

, 2016
In this chapter we review the electrostatic properties of charged membranes in aqueous solutions, with or without added salt, employing simple physical models.
Andelman, David, Markovich, Tomer, Podgornik, Rudi   +2 more
core  

Visual Molecular Dynamics Investigations of the Impact of Hydrophobic Nanoparticles on Prognosis of Alzheimer’s Disease and Cancers [PDF]

, 2012
The possible impact of hydrophobic lectin nanoparticles on the prognosis and progression of Alzheimer's disease (AD) and cancers was investigated by Visual Molecular Dynamics (VMD) computer modeling programs available from the Beckmann Advanced ...
I. C. Baianu, M Charles, V. I. Prisecaru
core   +1 more source

Mapping the druggable allosteric space of G-protein coupled receptors: a fragment-based molecular dynamics approach. [PDF]

, 2010
To address the problem of specificity in G-protein coupled receptor (GPCR) drug discovery, there has been tremendous recent interest in allosteric drugs that bind at sites topographically distinct from the orthosteric site. Unfortunately, structure-based
Ivetac, Anthony, McCammon, J Andrew
core   +2 more sources

Taming the Immiscibility of Gold, Iron, and Boron to Craft Chemodegradable Nanoparticles for Multimodal Imaging and Radiotherapy

Advanced Healthcare Materials, EarlyView.
Over half of cancer patients undergo radiotherapy. Laser ablation enabled the synthesis of immiscible Au‐Fe‐B nanoparticles designed as degradable bimodal radiosensitizers for X‐ray radiotherapy (XRT), boron neutron capture therapy (BNCT), and bimodal imaging for X‐ray computed tomography (CT) and magnetic resonance imaging (MRI). These nanosensitizers
Michael Bissoli, Clara M.G. de Faria, Veronica Torresan, Maria Assunta Lacavalla, Mattia Cattelan, Denis Badocco, Paolo Pastore, Pasquina Marzola, Laura Cansolino, Cinzia Ferrari, Ian Postuma, Riccardo Vago, Silva Bortolussi, Antonello E. Spinelli, Daniel Forrer, Vincenzo Amendola   +15 more
wiley   +1 more source

Investigations Into the Influence of Ionizable Lipids on the Stability of Lipid Nanoparticle

MedComm – Biomaterials and Applications
Messenger RNA‐loaded lipid nanoparticles (mRNA@LNPs) have achieved remarkable success in vaccine development, but their long‐term preservation imposes stringent requirements for transportation and storage. To broaden application of this technology, it is
Jie Wang, Zhitong Guo, Jun Yang, Haiyin Yang, Shaoping Jiang, Abid Naeem, Bo Hu, Yuhua Weng, Yuanyu Huang   +8 more
doaj   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source