Results 11 to 20 of about 15,472 (293)

Ionizable Lipid Nanoparticles for mRNA Delivery

Advanced NanoBiomed Research, 2023
Therapeutics based on messenger RNA (mRNA) have become a promising class of methods for various diseases’ treatments in recent years. The safe and effective delivery of mRNA into target cells is the premise of the clinical translation of mRNA. Due to the
Xuefeng Tang, Ying Zhang, Xiaojun Han
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Optimization of ionizable lipids for aerosolizable mRNA lipid nanoparticles

Bioengineering & Translational Medicine, 2023
Although mRNA lipid nanoparticles (LNPs) are highly effective as vaccines, their efficacy for pulmonary delivery has not yet fully been established. A major barrier to this therapeutic goal is their instability during aerosolization for local delivery ...
Mae M. Lewis, Melissa R. Soto, Esther Y. Maier, Steven D. Wulfe, Sandy Bakheet, Hannah Obregon, Debadyuti Ghosh   +6 more
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Overcoming thermostability challenges in mRNA–lipid nanoparticle systems with piperidine-based ionizable lipids

Communications Biology
Lipid nanoparticles (LNPs) have emerged as promising platforms for efficient in vivo mRNA delivery owing to advancements in ionizable lipids. However, maintaining the thermostability of mRNA/LNP systems remains challenging. While the importance of only a
Kazuki Hashiba, Masamitsu Taguchi, Sachiko Sakamoto, Ayaka Otsu, Yoshiki Maeda, Hirofumi Ebe, Arimichi Okazaki, Hideyoshi Harashima, Yusuke Sato   +8 more
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CHARMM-GUI Membrane Builder for Lipid Nanoparticles with Ionizable Cationic Lipids and PEGylated Lipids [PDF]

Journal of Chemical Information and Modeling, 2021
ABSTRACTA lipid nanoparticle (LNP) formulation is a state-of-the-art delivery system for genetic drugs such as DNA, mRNA, and siRNA, which is successfully applied to COVID-19 vaccines and gains tremendous interest in therapeutic applications. Despite its importance, a molecular-level understanding of the LNP structures and dynamics is still lacking ...
Soohyung Park, Yeol Kyo Choi, Seonghoon Kim, Jumin Lee, Wonpil Im   +4 more
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Ionizable lipid nanoparticles for in utero mRNA delivery [PDF]

Science Advances, 2021
Lipid nanoparticles deliver mRNA to mouse fetuses, which may ultimately enable in utero therapy to treat fetal genetic diseases.
Rachel S. Riley, Meghana V. Kashyap, Margaret M. Billingsley, Brandon White, Mohamad-Gabriel Alameh, Sourav K. Bose, Philip W. Zoltick, Hiaying Li, Rui Zhang, Andrew Y. Cheng, Drew Weissman, William H. Peranteau, Michael J. Mitchell   +12 more
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Characterization of Lipid Nanoparticles Containing Ionizable Cationic Lipids Using Design-of-Experiments Approach [PDF]

Langmuir, 2021
Lipid nanoparticles (LNPs) containing short-interfering RNA (LNP-siRNA systems) are a promising approach for silencing disease-causing genes in hepatocytes following intravenous administration. LNP-siRNA systems are generated by rapid mixing of lipids in ethanol with siRNA in aqueous buffer (pH 4.0) where the ionizable lipid is positively charged ...
Takeshi Terada, Jayesh A. Kulkarni, Ariel Huynh, Sam Chen, Roy van der Meel, Yuen Yi C. Tam, Pieter R. Cullis   +6 more
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Single pot organic solvent-free thermocycling technology for siRNA-ionizable LNPs: a proof-of-concept approach for alternative to microfluidics

Drug Delivery, 2022
Ionizable LNPs are the latest trend in nucleic acid delivery. Microfluidics technology has recently gained interest owing to its rapid mixing, production of nucleic acid-ionizable LNPs, and stability of nucleic acid inside the body.
Anindita De, Young Tag Ko
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In Cellulo and In Vivo Comparison of Cholesterol, Beta-Sitosterol and Dioleylphosphatidylethanolamine for Lipid Nanoparticle Formulation of mRNA

Nanomaterials, 2022
Lipid Nanoparticles (LNPs) are a leading class of mRNA delivery systems. LNPs are made of an ionizable lipid, a polyethyleneglycol (PEG)-lipid conjugate and helper lipids.
Ayoub Medjmedj, Albert Ngalle-Loth, Rudy Clemençon, Josef Hamacek, Chantal Pichon, Federico Perche   +5 more
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mRNA Synthesis and Encapsulation in Ionizable Lipid Nanoparticles

Current Protocols, 2023
AbstractmRNA vaccines have recently generated significant interest due to their success during the COVID‐19 pandemic. Their success is due to advances in mRNA design and encapsulation into ionizable lipid nanoparticles (iLNPs). This has highlighted the potential for the use of mRNA‐iLNPs in other settings such as cancer, gene therapy, or vaccines for ...
McKenzie, Rebecca Elizabeth, Minnell, Jordan James, Ganley, Mitch, Painter, Gavin Frank, Draper, Sarah   +4 more
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A Combinatorial Library of Lipid Nanoparticles for Cell Type‐Specific mRNA Delivery

Advanced Science, 2023
Ionizable lipid‐based nanoparticles (LNPs) are the most advanced non‐viral drug delivery systems for RNA therapeutics and vaccines. However, cell type‐specific, extrahepatic mRNA delivery is still a major hurdle, hampering the development of novel ...
Gonna Somu Naidu, Seok‐Beom Yong, Srinivas Ramishetti, Riccardo Rampado, Preeti Sharma, Assaf Ezra, Meir Goldsmith, Inbal Hazan‐Halevy, Sushmita Chatterjee, Anjaiah Aitha, Dan Peer   +10 more
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