Results 251 to 260 of about 15,472 (293)

Untargeted Metabolomics Identifies N‐Lactoyl‐Amino Acids as Dose‐Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Veronika Hola, Stanislava Rakusanova, Oliver Fiehn, Vojtech Skop, Ivana Lankova, Iva Miskova, Terezie Pelikanova, Martin Haluzik   +12 more
wiley   +1 more source

Causal Effects of Hydrophilic Bile Acids on Carfilzomib‐Related Cardiovascular Events in Multiple Myeloma: A Mendelian Randomization Study

Clinical Pharmacology &Therapeutics, EarlyView.
Carfilzomib is highly effective in the treatment of multiple myeloma, but it has been associated with cardiovascular adverse events that impact patient outcomes. Our prior global metabolomic analyses indicated an association between hydrophilic bile acids and carfilzomib‐cardiotoxicity risk, although a causal relationship remained to be determined ...
Samia Shabnaz, Eric Farber‐Eger, Marwa Tantawy, Neyousha Shahisavandi, Timothy J. Garrett, Samuel M. Rubinstein, Michael G. Fradley, Mohammed E. Alomar, Danny DeAvila, Kenneth H Shain, R. Frank Cornell, Daniel Lenihan, Qing Lu, Quinn S Wells, Rachid C. Baz, Yan Gong   +15 more
wiley   +1 more source

Annual Banned‐Substance Review 18th Edition—Analytical Approaches in Human Sports Drug Testing 2024/2025

Drug Testing and Analysis, EarlyView.
New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

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Substituting racemic ionizable lipids with stereopure ionizable lipids can increase mRNA delivery

Journal of Controlled Release, 2023
Lipid nanoparticles (LNPs) have delivered siRNA and mRNA drugs in humans, underscoring the potential impact of improving the therapeutic window of next-generation LNPs. To increase the LNP therapeutic window, we applied lessons from small-molecule chemistry to ionizable lipid design.
Alejandro J, Da Silva Sanchez, Kun, Zhao, Sebastian G, Huayamares, Marine Z C, Hatit, Melissa P, Lokugamage, David, Loughrey, Curtis, Dobrowolski, Shuaishuai, Wang, Hyejin, Kim, Kalina, Paunovska, Yanina, Kuzminich, James E, Dahlman   +11 more
openaire   +2 more sources

A fluorinated ionizable lipid improves the mRNA delivery efficiency of lipid nanoparticles

Journal of Materials Chemistry B, 2023
The combination of ionizable lipids bearing alkyl chains and fluorinated alkyl chains improves the cellular uptake and mRNA expression of lipid nanoparticles.
Haonan Huo, Xingdi Cheng, Jiaxi Xu, Jiaqi Lin, Ning Chen, Xueguang Lu   +5 more
openaire   +2 more sources

Iterative Design of Ionizable Lipids for Intramuscular mRNA Delivery

Journal of the American Chemical Society, 2023
Lipid nanoparticles (LNPs) are the most clinically advanced delivery vehicles for RNA and have enabled the development of RNA-based drugs such as the mRNA COVID-19 vaccines. Functional delivery of mRNA by an LNP greatly depends on the inclusion of an ionizable lipid, and small changes to these lipid structures can significantly improve delivery ...
Grayson Tilstra, Julien Couture-Senécal, Yan Ming Anson Lau, Alanna M. Manning, Daniel S. M. Wong, Wanda W. Janaeska, Titobioluwa A. Wuraola, Janice Pang, Omar F. Khan   +8 more
openaire   +2 more sources

Action of ionizing radiation on lipid-protein interaction

Biochemical and Biophysical Research Communications, 1982
Laser Raman spectroscopy has been used to investigate the effect of 137 Cs γ -rays (100 rad) on the interaction of proteolipid apoprotein in liposomes prepared from dipalmitoyl phosphatidylcholine + linoleic acid. Thermal transitions have been derived from the temperature-dependent CH-stretching features of the lipids. The low temperature transition (
S P, Verma, D F, Wallach
openaire   +2 more sources

Tetrahydropyrimidine Ionizable Lipids for Efficient mRNA Delivery

ACS Nano
Lipid nanoparticles (LNPs) have emerged as an effective and promising technology for messenger RNA (mRNA) delivery, offering a potential solution to physiological barriers and providing an alternative approach to gene therapy without the drawbacks associated with viral delivery.
Ivan Isaac, Altab Shaikh, Mayurakkhi Bhatia, Qian Liu, Seungman Park, Chandrabali Bhattacharya   +5 more
openaire   +2 more sources

Analysis of Lipids: Metal Oxide Laser Ionization Mass Spectrometry

Analytical Chemistry, 2012
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has been used for lipid analysis; however, one of the drawbacks of this technique is matrix interference peaks at low masses. Metal oxide surfaces are described here for direct, matrix-free analysis of small (MW < 1000 Da) lipid compounds, without interferences in the resulting ...
Casey R, McAlpin, Kent J, Voorhees, April R, Corpuz, Ryan M, Richards   +3 more
openaire   +2 more sources

The effect of ionizing radiation on lipid membranes

Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1991
Contrary to previous reviews, which provide a general survey about radiation effects on biomembranes, the present article concentrates on the lipid component. Two main objectives are envisaged: Radiation induced modification of membrane transport and the «inverse dose rate effect»
openaire   +2 more sources