Development of a Library of Disulfide Bond-Containing Cationic Lipids for mRNA Delivery
Pharmaceutics, 2023 Lipid nanoparticles (LNPs) are the commonly used delivery tools for messenger RNA (mRNA) therapy and play an indispensable role in the success of COVID-19 mRNA vaccines. Ionizable cationic lipids are the most important component in LNPs.
Zhigao Shen +8 more
doaj +1 more source
The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin. [PDF]
, 2002 Trypanosoma cruzi glutathione-dependent peroxidase I (TcGPXI) can reduce fatty acid, phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which enzyme activity is linked to the reduction of trypanothione, a parasite ...
Bromley, Elizabeth V +5 more
core +4 more sources
Lipid nanoparticles with ionizable lipids: Statistical aspects
Physical Review E, 2022 Lipid nanoparticles (LNPs) with size ∼100 nm are now used for fabrication of a new generation of drugs and antiviral vaccines. To optimize their function or, more specifically, interaction with cell membranes, their composition often includes ionizable lipids which are neutral or cationic (after association with H^{+}).
openaire +2 more sources
Ionizable lipids in bio-inspired nanocarriers
European Biophysics Journal, 2023 AbstractIn applications of bio-inspired nanoparticles (NPs), their composition is often optimised by including ionizable lipids. I use a generic statistical model to describe the charge and potential distributions in lipid nanoparticles (LNPs) containing such lipids.
openaire +2 more sources
Prediction of lipid nanoparticles for mRNA vaccines by the machine learning algorithm
Acta Pharmaceutica Sinica B, 2022 Lipid nanoparticle (LNP) is commonly used to deliver mRNA vaccines. Currently, LNP optimization primarily relies on screening ionizable lipids by traditional experiments which consumes intensive cost and time.
Wei Wang +5 more
doaj +1 more source
The Overlooked Stereoisomers of the Ionizable Lipid ALC315. [PDF]
J Am Chem SocLipid nanoparticles (LNPs) are a powerful delivery platform for nucleic acid therapeutics such as mRNA vaccines and gene therapies. Central to their success are ionizable lipids, which facilitate the cellular uptake and endosomal escape of nucleic acids.
De CK +9 more
europepmc +3 more sources
Lipid nanoparticles employed in mRNA-based COVID-19 vaccines: An overview of materials and processes used for development and production [PDF]
Arhiv za farmaciju, 2022 In the light of the recommended application of the third dose, both public and professional community would benefit from a detailed report on the technological advances behind the developed messenger ribonucleic acid (mRNA) based COVID-19 vaccines ...
Pantelić Ivana +3 more
doaj +1 more source
Ionizable amino lipid interactions with POPC: implications for lipid nanoparticle function
Nanoscale, 2019 The distribution of ionizable amino lipids (KC2) is critical in structure of lipid nanoparticles, siRNA entrapment and endosomal release. Neutral KC2 segregates from phospholipids (POPC) and forms an oily core in the bilayer interior.
M. Ramezanpour +7 more
openaire +2 more sources
Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice [PDF]
, 2014 Lipid composition, particularly membrane unsaturation, has been proposed as being a lifespan determinant, but it is currently unknown whether caloric restriction (CR), an accepted life-extending intervention, affects cellular lipid profiles.
Jové, Mariona +6 more
core +3 more sources
Recent Advances in the Lipid Nanoparticle-Mediated Delivery of mRNA Vaccines
Vaccines, 2023 Lipid nanoparticles (LNPs) have recently emerged as one of the most advanced technologies for the highly efficient in vivo delivery of exogenous mRNA, particularly for COVID-19 vaccine delivery.
K. Swetha +7 more
doaj +1 more source