Results 41 to 50 of about 15,472 (293)

Design of cationic ionizable lipids for the delivery of therapeutic nucleic acids

Molecular Therapy: Methods & Clinical Development
Ionizable cationic lipids are a critical component of lipid nanoparticles (LNPs), enabling the clinical success of nucleic acid therapeutics through effective encapsulation, delivery, and release.
N. D. Prasad Atmuri, Fariba Saadati, Jayesh Kulkarni, Dominik Witzigmann, Pieter R. Cullis, Marco A. Ciufolini   +5 more
doaj   +1 more source

Synthetic Ionizable Colloidal Drug Aggregates Enable Endosomal Disruption

Advanced Science, 2023
Colloidal drug aggregates enable the design of drug‐rich nanoparticles; however, the efficacy of stabilized colloidal drug aggregates is limited by entrapment in the endo‐lysosomal pathway.
Eric N. Donders, Kai V. Slaughter, Christian Dank, Ahil N. Ganesh, Brian K. Shoichet, Mark Lautens, Molly S. Shoichet   +6 more
doaj   +1 more source

Modulation of elasticity and interactions in charged lipid multibilayers: monovalent salt solutions

, 2016
We have studied the electrostatic screening effect of NaCl solutions on the interactions between anionic lipid bilayers in the fluid lamellar phase using a Poisson-Boltzmann based mean-field approach with constant charge and constant potential limiting ...
Belička, Michal, Gupta, Santosh, Lu, Bing-Sui, Pabst, Georg, Podgornik, Rudolf   +4 more
core   +3 more sources

Pathogenic mutations in the hydrophobic core of the human prion protein can promote structural instability and misfolding [PDF]

, 2010
Transmissible spongiform encephalopathies, or prion diseases, are caused by misfolding and aggregation of the prion protein PrP. These diseases can be hereditary in humans and four of the many disease-associated missense mutants of PrP are in the ...
Daggett, Valerie, van der Kamp, Marc W
core   +2 more sources

Comparison of ionizable lipids for lipid nanoparticle mediated DNA delivery

European Journal of Pharmaceutical Sciences
Lipid nanoparticles (LNPs) are successfully used for RNA-based gene delivery. In the context of gene replacement therapies, however, delivery of DNA expression plasmids using LNPs as a non-viral vector could be a promising strategy for the induction of longer-lasting effects.
Claudia Lotter, Evrim Ümit Kuzucu, Jens Casper, Claudio Luca Alter, Ramya Deepthi Puligilla, Pascal Detampel, Juana Serrano Lopez, Alexander Sebastian Ham, Jörg Huwyler   +8 more
openaire   +2 more sources

AGILE platform: a deep learning powered approach to accelerate LNP development for mRNA delivery

Nature Communications
Ionizable lipid nanoparticles (LNPs) are seeing widespread use in mRNA delivery, notably in SARS-CoV-2 mRNA vaccines. However, the expansion of mRNA therapies beyond COVID-19 is impeded by the absence of LNPs tailored for diverse cell types.
Yue Xu, Shihao Ma, Haotian Cui, Jingan Chen, Shufen Xu, Fanglin Gong, Alex Golubovic, Muye Zhou, Kevin Chang Wang, Andrew Varley, Rick Xing Ze Lu, Bo Wang, Bowen Li   +12 more
doaj   +1 more source

Effect of mRNA-LNP components of two globally-marketed COVID-19 vaccines on efficacy and stability

npj Vaccines, 2023
During the COVID-19 pandemic, Pfizer-BioNTech and Moderna successfully developed nucleoside-modified mRNA lipid nanoparticle (LNP) vaccines. SARS-CoV-2 spike protein expressed by those vaccines are identical in amino acid sequence, but several key ...
Lizhou Zhang, Kunal R. More, Amrita Ojha, Cody B. Jackson, Brian D. Quinlan, Hao Li, Wenhui He, Michael Farzan, Norbert Pardi, Hyeryun Choe   +9 more
doaj   +1 more source

Ion-Specific Hydration Effects: Extending the Poisson-Boltzmann Theory

, 2011
In aqueous solutions, dissolved ions interact strongly with the surrounding water, thereby modifying the solution properties in an ion-specific manner. These ion-hydration interactions can be accounted for theoretically on a mean-field level by including
Andelman, David, Ben-Yaakov, Dan, Harries, Daniel, Podgornik, Rudi   +3 more
core   +1 more source

Calculating Apparent pKa Values of Ionizable Lipids in Lipid Nanoparticle

Molecular Pharmaceutics
Creating new ionizable lipids for use in lipid nanoparticles (LNPs) is an active field of research. One of the critical properties for selecting suitable ionizable lipids is the apparent pKa value of the lipid as formulated in an LNP. We have developed a structure-based, computational methodology for the prediction of the apparent pKa value of ...
Nicholas B. Hamilton, Steve Arns, Mee Shelley, Irene Bechis, John C. Shelley   +4 more
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source