Results 71 to 80 of about 15,472 (293)

Carbohydrate-derived amphiphilic macromolecules: a biophysical structural characterization and analysis of binding behaviors to model membranes. [PDF]

, 2015
The design and synthesis of enhanced membrane-intercalating biomaterials for drug delivery or vascular membrane targeting is currently challenged by the lack of screening and prediction tools.
Gu, Li, Kholodovych, Vladyslav, Martin, Adriana AT, Moghe, Prabhas V, Murthy, N Sanjeeva, Sommerfeld, Sven Daniel, Tomasini, Michael, Uhrich, Kathryn E, Welsh, William J   +8 more
core   +2 more sources

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source

On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA [PDF]

ACS Nano, 2018
Lipid nanoparticles (LNPs) containing short interfering RNA (LNP-siRNA) and optimized ionizable cationic lipids are now clinically validated systems for silencing disease-causing genes in hepatocytes following intravenous administration. However, the mechanism of formation and certain structural features of LNP-siRNA remain obscure.
Jayesh A. Kulkarni, Maria M. Darjuan, Joanne E. Mercer, Sam Chen, Roy van der Meel, Jenifer L. Thewalt, Yuen Yi C. Tam, Pieter R. Cullis   +7 more
openaire   +3 more sources

Structure-based statistical analysis of transmembrane helices [PDF]

, 2013
Recent advances in determination of the high-resolution structure of membrane proteins now enable analysis of the main features of amino acids in transmembrane (TM) segments in comparison with amino acids in water-soluble helices.
A Holt, A Saurí, A Senes, ACV Johansson, Carlos Baeza-Delgado, DE Engel, E Wallin, FS Cordes, G Heijne von, HJ Sharpe, HM Berman, I Nilsson, I Nilsson, Ismael Mingarro, IT Arkin, J Nilsson, JL MacCallum, JU Bowie, K Illergård, L Martínez-Gil, L Pal, M Blaber, M Eilers, M Lerch-Bader, M Orzáez, MA Lomize, Marc A. Marti-Renom, MB Ulmschneider, MB Ulmschneider, RW Williams, S Jayasinghe, S Jayasinghe, SC Li, SH White, SH White, SH White, T Hessa, T Hessa   +37 more
core   +2 more sources

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source

Biological insertion of computationally designed short transmembrane segments [PDF]

, 2016
The great majority of helical membrane proteins are inserted co-translationally into the ER membrane through a continuous ribosome-translocon channel. The efficiency of membrane insertion depends on transmembrane (TM) helix amino acid composition, the ...
Baeza Delgado, Carlos, Heijne, Gunnar von, Martí Renom, Marc A., Mingarro Muñoz, Ismael   +3 more
core   +3 more sources

High‐Resolution Characterization of Protein‐Conjugated, mRNA‐Loaded Lipid Nanoparticles by Analytical Ultracentrifugation

Advanced Functional Materials, EarlyView.
Lipid nanoparticles containing messenger RNA are characterized by sedimentation velocity analytical ultracentrifugation using UltraScan's new Custom Grid algorithm to provide multi‐dimensional distributions for partial specific volume (particle density), molar mass, sedimentation, diffusion, and hydrodynamic radius.
Sophia Bird, Connor Smith, Nahal Habibi, Samantha Rivera, Saeed Mortezazadeh, Reece Martin, Benjamin M. Geilich, Gilles Besin, Borries Demeler   +8 more
wiley   +1 more source

PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

Advanced Functional Materials, EarlyView.
PREdicting LNP In Vivo Efficacy (PRELIVE) framework enables the prediction of lipid nanoparticle (LNPs) organ‐specific delivery through dual modeling approaches. Composition‐based models using formulation parameters and protein corona‐based models using biological fingerprints both achieve high predictive accuracy across multiple organs.
Belal I. Hanafy, Chuan‐En Lu, Kai Liu, Audrey Gallud   +3 more
wiley   +1 more source

A semi-grand canonical Monte Carlo simulation model for ion binding to ionizable surfaces: proton binding of carboxylated latex particles as a case study [PDF]

, 2011
In this paper, we present a computer simulation study of the ion binding process at an ionizable surface using a semi-grand canonical Monte Carlo method that models the surface as a discrete distribution of charged and neutral functional groups in ...
David, Calin, Garcés, Josep Lluís, Madurga Díez, Sergio, Mas i Pujadas, Francesc, Pastor, Isabel, Puy, Jaume, Rey-Castro, Carlos, Vilaseca i Font, Eudald   +7 more
core   +2 more sources

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source