Results 81 to 90 of about 15,472 (293)
Liposomal lipid nanoparticles for extrahepatic delivery of mRNA
Nature CommunicationsLong-circulating, transfection-competent lipid nanoparticle (LNP)-mRNA delivery systems are critical for achieving efficient transfection in extrahepatic tissues.
Miffy Hok Yan Cheng +16 more
doaj +1 more source
Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles
Bioengineering & Translational Medicine, 2021 Ionizable lipid nanoparticles (LNPs) are the most clinically advanced nano‐delivery system for therapeutic nucleic acids. The great effort put in the development of ionizable lipids with increased in vivo potency brought LNPs from the laboratory benches ...
Michele Schlich +6 more
doaj +1 more source
Ion Induced Lamellar-Lamellar Phase Transition in Charged Surfactant Systems
, 2006 We propose a model for the liquid-liquid phase transition observed in osmotic pressure measurements of certain charged lamellae-forming amphiphiles.
Andelman, David +4 more
core +1 more source
New water-soluble carbamate ester derivatives of resveratrol [PDF]
, 2014 Low bioavailability severely hinders exploitation of the biomedical potential of resveratrol. Extensive phase-II metabolism and poor water solubility contribute to lowering the concentrations of resveratrol in the bloodstream after oral administration ...
Azzolini, Michele +5 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis +19 more
wiley +1 more source
Membrane‐destabilizing ionizable lipid empowered imaging‐guided siRNA delivery and cancer treatment
Exploration, 2021 One of the imperative medical requirements for cancer treatment is how to establish an imaging‐guided nanocarrier that combines therapeutic and imaging agents into one system.
Shuai Guo +14 more
doaj +1 more source
Advances in the delivery of RNA therapeutics: from concept to clinical reality [PDF]
, 2017 - The rapid expansion of the available genomic data continues to greatly impact biomedical science and medicine. Fulfilling the clinical potential of genetic discoveries requires the development of therapeutics that can specifically modulate the ...
Anderson, Daniel Griffith +2 more
core +1 more source
Advanced Healthcare Materials, EarlyView.A methacrylamide β‐cyclodextrin‐based nanogel (MACD nGel) is developed to load the antimicrobial drug Metronidazole (MNZ) for topical delivery for the treatment of periodontitis. It is demonstrated that cyclodextrin nanogel (nGel) loaded with metronidazole provides an efficient drug delivery route but also has potential clinical applications and offers
Yanjing Ji +8 more
wiley +1 more source
Dynamic hydration valve controlled ion permeability and stability of NaK channel [PDF]
, 2008 The K^+^, Na^+^, Ca^2+^ channels are essential to neural signalling, but our current knowledge at atomic level is mainly limited to that of K^+^ channels.
Rong Shen, Wanlin Guo, Wenyu Zhong
core +1 more source
Smart Catheters for Diagnosis, Monitoring, and Therapy
Advanced Healthcare Materials, EarlyView.This study presents a comprehensive review of smart catheters, an emerging class of medical devices that integrate embedded sensors, robotics, and communication systems, offering increased functionality and complexity to enable real‐time health monitoring, diagnostics, and treatment. Abstract This review explores smart catheters as an emerging class of
Azra Yaprak Tarman +12 more
wiley +1 more source