Results 61 to 70 of about 469,706 (316)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The role of the tongue-of-ionization in the formation of the poleward wall of the main trough in the European post-midnight sector

, 2008
A series of radio tomography reconstructions from the University of Wales Aberystwyth receiver chains in Scandinavia and the UK, imaging the midnight-dawn sector on 13 December 2001, reveal a persistent large-scale electron density enhancement, which ...
Wood, Alan, Pryse, SE, Balthazor, R, Middleton, Helen Rose, Balthazor, Richard, Middleton, HR, Wood, AG   +6 more
core   +1 more source

Matrix-assisted laser desorption/ionization time of flight mass spectrometry for comprehensive indexing of East African ixodid tick species [PDF]

, 2016
Background: The tick population of Africa includes several important genera belonging to the family Ixodidae. Many of these ticks are vectors of protozoan and rickettsial pathogens including Theileria parva that causes East Coast fever, a debilitating ...
Olds, C., Pflüger, V., Stephen Mwaura, Julian Rothen, Cassandra Olds, Bishop, Richard P., Daubenberger, C.A., Richard P. Bishop, Olds, Cassandra L., Pflueger, V., Esther G. Kanduma, Githaka, Naftaly W., Daubenberger, C., Rothen, J., Valentin Pflüger, Githaka, N., KAnduma, E. G., Mwaura, S., Bishop, R. P., Naftaly Githaka, Claudia Daubenberger, Kanduma, Esther G.   +21 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Unstable Leader Inception Criteria of Atmospheric Discharges

Atmosphere, 2017
In the literature, there are different criteria to represent the formation of a leader channel in short and long gap discharges. Due to the complexity of the physics of the heating phenomena, and the limitations of the computational resources, a ...
Liliana Arevalo, Vernon Cooray
doaj   +1 more source

Optimizing ideal ion propulsion systems depending on the nature of the propellant [PDF]

INCAS Bulletin, 2016
From all accounts the ion thrusters are characterized by the fact that they produce a very high exhaust velocity and specific impulse, sometimes too high for many missions.
Grigore CICAN, Ionut-Florian POPA
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Plasma formation in the air medium under ordinary pressure and its interaction with solid metal surfaces

Moldavian Journal of the Physical Sciences, 2015
The conditions for obtaining an electrical discharge plasma in a gaseous media, as well as its application in different fields of nanotechnology, are analyzed in this paper.
Hîrbu, Arefa
doaj  

Principles of Electrospray Ionization [PDF]

Molecular & Cellular Proteomics, 2011
Electrospray ionization is today the most widely used ionization technique in chemical and biochemical analysis. Interfaced with a mass spectrometer it allows the investigation of the molecular composition of liquid samples. With electrospray a large variety of chemical substances can be ionized.
openaire   +5 more sources