Results 71 to 80 of about 469,706 (316)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

General phenomenology of ionization from aligned molecular ensembles

New Journal of Physics, 2015
Single and multi-photon ionization of aligned molecular ensembles is examined, with a particular focus on the link between the molecular axis distribution and observable in various angle-integrated and angle-resolved measurements.
Paul Hockett
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Relative affinity constants by electrospray ionization and Fourier transform ion cyclotron resonance mass spectrometry: calmodulin binding to peptide analogs of myosin light chain kinase [PDF]

, 2003
Synthetic RS20 peptide and a set of its point-mutated peptide analogs have been used to analyze the interactions between calmodulin (CaM) and the CaM-binding sequence of smooth-muscle myosin light chain kinase both in the presence and the absence of Ca2+.
Lafitte, Daniel, Vainiotalo, Pirjo, Nousiainen, Marjaana, Derrick, Peter J.   +3 more
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Detailed and simplified nonequilibrium helium ionization in the solar atmosphere

, 2014
Helium ionization plays an important role in the energy balance of the upper chromosphere and transition region. Helium spectral lines are also often used as diagnostics of these regions.
Golding, Thomas Peter, Carlsson, Mats, Leenaarts, Jorrit   +2 more
core   +1 more source

Basic principle from electrospray ionization to soft ionization mass spectrometry and development of ion source: part Ⅱ

, 2023
This paper continue talking about some questions in the experimental phenomenon and basic principle of soft ionization mass spectrometry, describe the forces between the charge and the analyte, ideal model of soft ionization technology, multi-charge and ...
Jiehong, Luo
core   +1 more source

Molecular properties, including chameleonicity, as essential tools for designing the next generation of oral beyond rule of five drugs

ADMET and DMPK
Background and Purpose. The classical drug discovery toolbox continually expands beyond traditional rule of five (Ro5)-compliant small molecules to include new chemical modalities for difficult-to-drug targets.
Giulia Caron, Diego Garcia Jimenez, Maura Vallaro, Luigi Vitagliano, Lucia Lopez Lopez, Giulia Apprato, Giuseppe Ermondi   +6 more
doaj   +1 more source

The Ionization Mechanism in Radioactive Ionization Detector

The Journal of the Society of Chemical Industry, Japan, 1965
放射線イオン化検出器の分野では,イオン化ポテンシャル(以下1.P・と略す)が,アルゴンの励起状態の原子の11.6eVよりも低い一般の有機ガスの場合を除いて,イオン化機構に関する研究がほとんどされていない。著者らは先の報文で,RaD100μcのα線源を内蔵する放射線イオン化検出器を用いた無機ガスの分析に関する報告を行なった。この研究の一環として,この報文ではI.P.が11.6eV以上のサソプルガスとして,モレキュラーシーブ5Aカラムのガスクロマトグラフィーで,空気から分離した酸素と窒素を用い,キャリヤーガスに,アルゴン,有機蒸気を含れアルゴン,ヘリウムおよび水素を用いた場合の実験結果を考察して,“Penning効果”,加速電子およびα 線による直接のイオン化 ...
Shin TSUGE, Tsugio TAKEUCHI
openaire   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source