Results 71 to 80 of about 1,418,864 (329)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Plasma formation in the air medium under ordinary pressure and its interaction with solid metal surfaces

Moldavian Journal of the Physical Sciences, 2015
The conditions for obtaining an electrical discharge plasma in a gaseous media, as well as its application in different fields of nanotechnology, are analyzed in this paper.
Hîrbu, Arefa
doaj  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

General phenomenology of ionization from aligned molecular ensembles

New Journal of Physics, 2015
Single and multi-photon ionization of aligned molecular ensembles is examined, with a particular focus on the link between the molecular axis distribution and observable in various angle-integrated and angle-resolved measurements.
Paul Hockett
doaj   +1 more source

Ionization state of inter-stellar medium in galaxies: evolution, SFR-M * -Z dependence, and ionizing photon escape [PDF]

, 2013
We present a systematic study for ionization state of inter-stellar medium in galaxies at z=0-3 with ~140,000 SDSS galaxies and 108 intermediate to high redshift galaxies from the literature, using an ionization-parameter sensitive line ratio of [OIII ...
K. Nakajima, M. Ouchi
semanticscholar   +1 more source

Method of predicting ionization-type vacuum gage sensitivity for various gases [PDF]

, 1973
Sensitivity of gage for one gas can be correlated to its sensitivity for other gases by the ratio of gas ionization cross sections. Ionization cross sections which best correlate with gage sensitivites vary according to gage type and ionization cross ...
Holanda, R.
core   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Ionization of acetonitrile [PDF]

International Journal of Mass Spectrometry, 2019
Abstract The ionization of acetonitrile has been studied using both electron and photon ionization combined with coincidence detection techniques. Relative partial ionization cross sections and relative precursor-specific partial ionization cross-sections are determined for all the cations formed from single, double and triple electron ionization of ...
Michael A. Parkes, Kevin M. Douglas, Stephen D. Price   +2 more
openaire   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Molecular properties, including chameleonicity, as essential tools for designing the next generation of oral beyond rule of five drugs

ADMET and DMPK
Background and Purpose. The classical drug discovery toolbox continually expands beyond traditional rule of five (Ro5)-compliant small molecules to include new chemical modalities for difficult-to-drug targets.
Giulia Caron, Diego Garcia Jimenez, Maura Vallaro, Luigi Vitagliano, Lucia Lopez Lopez, Giulia Apprato, Giuseppe Ermondi   +6 more
doaj   +1 more source