Results 21 to 30 of about 108,928 (238)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Exploring Non-Genetic Factors in Cancer Resistance among Ramsar Residents: From Medical Geology to the Role of Diet: A Review [PDF]

International Journal of Nutrition Sciences
Ramsar in northern Iran provides a unique natural setting to investigate the biological effects of exposure to chronic radiation and the potential adaptive mechanisms. It is owing to its exceptional high concentrations of radium in sedimentary rocks, hot
Hassan Bahrami, Pouya Zohdparast, Hassan Vafapour, AmirAli Fallah, Seyed Mohammad Javad Mortazavi, Fateme Zaker, Maryam Arshadi, Alireza Mortazavi, Seyed Jalil Masoumi   +8 more
doaj   +1 more source

Risk Factors for Childhood Leukemia: Radiation and Beyond

Frontiers in Public Health, 2021
Childhood leukemia (CL) is undoubtedly caused by a multifactorial process with genetic as well as environmental factors playing a role. But in spite of several efforts in a variety of scientific fields, the causes of the disease and the interplay of ...
Janine-Alison Schmidt, Sabine Hornhardt, Friederike Erdmann, Friederike Erdmann, Isidro Sánchez-García, Ute Fischer, Joachim Schüz, Gunde Ziegelberger   +7 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Intermediate frequency magnetic field at 250.8 kHz does not induce DNA damage or “Adaptive Response” in vitro

Genetics & Applications, 2019
The aim of this study was to examine whether intermediate frequency (IF) magnetic field (MF) induces genotoxic effects or play a role in the induction of adaptive response after combined exposure to IF MF and ionizing radiation in leukocytes and in ...
Zsuzsanna Németh, Erzsébet Laczkovich-Szaladják, Annamária Brech, Zsófia Szilágyi, Györgyi Kubinyi, György Thuróczy   +5 more
doaj   +3 more sources

The Critical Role of Radiation Protection in Modern Life [PDF]

Journal of Biomedical Physics and Engineering
The Critical Role of Radiation Protection in Modern LifeThe Critical Role of Radiation Protection in Modern LifeThe Critical Role of Radiation Protection in Modern LifeThe Critical Role of Radiation Protection in Modern LifeThe Critical Role of Radiation
James Welsh, Seyed Mohammad Javad Mortazavi, Lembit Sihver   +2 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Synergic Effect of TC99-m Gamma Radiation and Non-ionizing Radiation of Wi-Fi on Count, Morphology and Motility of Sperms in Rats: An Experimental Study

Iranian South Medical Journal, 2020
Background: Given the effects of ionizing radiation on biological tissues and their irreversible tissue damage, this project aimed to determine the synergic effect of TC99-m gamma radiation and non-ionizing radiation of Wi-Fi on sperm characteristics in ...
Farshid Gheisari, Mohammad Atefi, Aref Masoumirad   +2 more
doaj  

Effect of Microwave Wi-Fi Radiation at Frequency of 2.4 GHz on Epileptic Behavior of Rats

Journal of Biomedical Physics and Engineering, 2018
Background: Electromagnetic fields (EMF) with different intensities are widely used at home, offices and public places.Today, there is a growing global concern about the effects of human exposure to EMFs.
Mahmoudi A., Shojaeifard M. B., Nematollahii S., Mortazavi S. M. J., Mehdizadeh A. R.   +4 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source