Results 31 to 40 of about 1,241,883 (304)

Ionizing radiation effects on blood-derived extracellular vesicles: insights into miR-34a-5p-mediated cellular responses and biomarker potential

Cell Communication and Signaling
Adverse effects of ionizing radiation on normal tissues limit the radiation dose in cancer treatment, thereby compromising treatment efficiency. Among the consistently affected non-cancer cells, peripheral blood mononuclear cells (PBMCs) exhibit high ...
Chiara Huber, Omar Elsaeed, Pia Lahmer, Simone Moertl   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Exploring Non-Genetic Factors in Cancer Resistance among Ramsar Residents: From Medical Geology to the Role of Diet: A Review [PDF]

International Journal of Nutrition Sciences
Ramsar in northern Iran provides a unique natural setting to investigate the biological effects of exposure to chronic radiation and the potential adaptive mechanisms. It is owing to its exceptional high concentrations of radium in sedimentary rocks, hot
Hassan Bahrami, Pouya Zohdparast, Hassan Vafapour, AmirAli Fallah, Seyed Mohammad Javad Mortazavi, Fateme Zaker, Maryam Arshadi, Alireza Mortazavi, Seyed Jalil Masoumi   +8 more
doaj   +1 more source

Ionizing Radiation and Life [PDF]

Astrobiology, 2011
Ionizing radiation is a ubiquitous feature of the Cosmos, from exogenous cosmic rays (CR) to the intrinsic mineral radioactivity of a habitable world, and its influences on the emergence and persistence of life are wide-ranging and profound. Much attention has already been focused on the deleterious effects of ionizing radiation on organisms and the ...
openaire   +3 more sources

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Synergic Effect of TC99-m Gamma Radiation and Non-ionizing Radiation of Wi-Fi on Count, Morphology and Motility of Sperms in Rats: An Experimental Study

Iranian South Medical Journal, 2020
Background: Given the effects of ionizing radiation on biological tissues and their irreversible tissue damage, this project aimed to determine the synergic effect of TC99-m gamma radiation and non-ionizing radiation of Wi-Fi on sperm characteristics in ...
Farshid Gheisari, Mohammad Atefi, Aref Masoumirad   +2 more
doaj  

Effect of Microwave Wi-Fi Radiation at Frequency of 2.4 GHz on Epileptic Behavior of Rats

Journal of Biomedical Physics and Engineering, 2018
Background: Electromagnetic fields (EMF) with different intensities are widely used at home, offices and public places.Today, there is a growing global concern about the effects of human exposure to EMFs.
Mahmoudi A., Shojaeifard M. B., Nematollahii S., Mortazavi S. M. J., Mehdizadeh A. R.   +4 more
doaj   +1 more source

Intermediate frequency magnetic field at 250.8 kHz does not induce DNA damage or “Adaptive Response” in vitro

Genetics & Applications, 2019
The aim of this study was to examine whether intermediate frequency (IF) magnetic field (MF) induces genotoxic effects or play a role in the induction of adaptive response after combined exposure to IF MF and ionizing radiation in leukocytes and in ...
Zsuzsanna Németh, Erzsébet Laczkovich-Szaladják, Annamária Brech, Zsófia Szilágyi, Györgyi Kubinyi, György Thuróczy   +5 more
doaj   +3 more sources