Results 101 to 110 of about 63,777 (241)

Steric and Stereochemical Modulation in Pyridyl- and Quinolyl-Containing Ligands

Molecules, 2016
Nitrogen-containing pyridine and quinoline are outstanding platforms on which excellent ionophores and sensors for metal ions can be built. Steric and stereochemical effects can be used to modulate the affinity and selectivity of such ligands toward ...
Zhaohua Dai
doaj   +1 more source

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, Volume 13, Issue 25, 4 May 2026.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

Multi‐Organelle Stress‐Induced Paraptosis by a ROS‐Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy

Advanced Science, Volume 13, Issue 26, 8 May 2026.
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu, Haozhe Ren, Hua Li, Jinghan Zhao, Miaomiao Cao, Tian Tang, Youbei Qiao, Liting Chen, Tiehong Yang, Hong Wu   +9 more
wiley   +1 more source

Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms [PDF]

, 2018
Platelet-activating factor (PAF) stimulates numerous cell types via activation of the G protein-coupled PAF receptor (PAFR). PAFR activation not only induces acute proinflammatory responses, but it also induces delayed systemic immunosuppressive effects ...
FitzGerald, Garret A., Kaplan, Mark H., Ocana, Jesus A., Pawelzik, Sven-Christian, Romer, Eric, Sahu, Ravi, Travers, Jeffrey B.   +6 more
core   +1 more source

Ba2+‐Selective and pH‐Stable Dibenzo‐18‐Crown‐6 Equipped BODIPYs with Pronounced Fluorescence Enhancement in Aqueous Solution

ChemPhotoChem, Volume 10, Issue 5, May 2026.
Herein, we report on a Ba2+ selective, Ba2+ sensitive, and pH stable fluorescent probe with a high photostability in water (cf. TOC). This fluorescent probe is equipped with a dibenzo‐18‐crown‐6 as a highly selective Ba2+ ionophore and a tetramethylated BODIPY fluorophore.
Thomas Schwarze, Tobias Sprenger, Mazen Al Akrami, Almut Tabea Lohoff, Eric Sperlich, Sascha Eidner, Michael Uwe Kumke, Nora Kulak   +7 more
wiley   +1 more source

Increased SK3 expression in DM1 lens cells leads to impaired growth through a greater calcium-induced fragility [PDF]

, 2006
Although cataract is a characteristic feature of myotonic dystrophy type 1 (DM1), little is known of the underlying mechanisms. We generated four lens epithelial cell lines derived from DM1 cataracts and two from age-matched, non-DM cataracts. Small-pool
Abe, Alan R. Prescott, Anvret, Behrens, Benders, Collison, Darren G. Monckton, Delamere, Diecke, Duke-Elder, Duncan, Dunne, Fleming, George Duncan, Gomes-Pereira, Gomes-Pereira, Harper, Harris, Hull, James, Jeremy D. Rhodes, Jin, John P. McAbney, Khajavi, Khan, Kimura, Klesert, Lauf, Monckton, O'Cochlain, Pham, Remillard, Renaud, Rhodes, Sanderson, Sarkar, Stocker, Sun, Tapscott, Vergara, Winchester   +40 more
core   +2 more sources

Cyclic Peptide Conformational Landscapes Through the Lens of Mass Spectrometry and Orthogonal Spectroscopy

Journal of Mass Spectrometry, Volume 61, Issue 5, May 2026.
ABSTRACT Cyclic peptides occupy a structurally dynamic region of chemical space, where function often arises from ensembles rather than a single dominant fold. Closed backbones, frequent N‐methylation, heteroatoms, unnatural amino acids, and a strong propensity for metal coordination create dense conformational and coordination landscapes that ...
Emmanuel Nkyaagye, Happy Abena Safoah, Thanh D. Do   +2 more
wiley   +1 more source

Desempenho de bezerras de corte em pastagem de azevém recebendo farelo de arroz com ou sem monensina

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
RESUMO Foi estudado o desempenho de bezerras de corte em pastagem de azevém (Lolium multiflorum Lam.), com animais exclusivamente em pastejo ou recebendo farelo de arroz integral (FAI) em nível de 0,8% do peso corporal, associado ou não à monensina.
L.L. Biscaíno, M.G. Rocha, L. Pötter, L.R. Eloy, A.M. da Fonseca Neto, M.B. Alves, L.A. Graminho, M.J.O. Sichonany   +7 more
doaj   +1 more source

Fluorescence and Naked-Eye Detection of Pb²⁺ in Drinking Water Using a Low-Cost Ionophore Based Sensing Scheme

Chemosensors, 2018
Drinking water contamination of lead from various environmental sources, leaching consumer products, and intrinsic water-pipe infrastructure is still today a matter of great concern. Therefore, new highly sensitive and convenient Pb2+ measurement schemes
Aron Hakonen, Niklas Strömberg
doaj   +1 more source

高齢者気管支喘息における気道過敏性と温泉療法 [PDF]

, 2001
Clinical effects of spa therapy were examined in 150 patients with asthma in relation tobronchial hyperresponsiveness and patient age. 1. The efficacy rate of spa therapy was larger as the patient age was higher: the rate was 73.3% in patients under age ...
Ashida, Kozo, Hosaki, Yasuhiro, Mifune, Takashi, Mitsunobu, Fumihiro, Ochi, Koji, Okamoto, Makoto, Takata, Shingo, Tanizaki, Yoshiro, Tsugeno, Hirofumi   +8 more
core   +1 more source