Results 101 to 110 of about 15,483 (233)
The vasculo‐splenic axis during exercise: shear stress triggers the release of medium/large extracellular vesicles from vascular endothelial cells via activation of Piezo1, shuttling Piezo1 to the smooth muscle cells in the splenic capsule; the translocated Piezo1 within the splenic capsule acts as a downstream effector of the α1‐adrenergic receptor ...
Jing Lou +12 more
wiley +1 more source
Neutrophil Extracellular Traps in Atherosclerosis and Cardiovascular Disease
NETs as integrated effectors in the atherosclerotic cardiovascular disease continuum. Activated neutrophils release NETs that promote endothelial injury, thrombo‐inflammation, and plaque destabilization throughout atherosclerotic disease progression. Created with BioRender.com.
Ji Zhang +9 more
wiley +1 more source
Interaction of carrier ionophores with phospholipid vesicles
The interactions of carrier ionophores, nonactin, A23187, and lasalocid A with liposomes formed from the synthetic lipids dimyristoylphosphatidylcholine and dipalmitoylphosphatidylcholine are investigated by differential scanning calorimetry and {^1H ...
Easwaran, Kalpathy RK +2 more
core
Iron and Other Metal Ions in Human Health and Disease
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley +1 more source
Mechanisms of Hop Inhibition: Hop Ionophores
In this work, the mechanism of hop inhibition toward (beer spoiling) bacteria is revised. The mode of action of iso-α-acids was investigated via bilayer lipid membrane (BLM) measurements and growth challenges of hop-sensitive and -resistant Lactobacillus
Rudi F. Vogel (1825852) +1 more
core +1 more source
Hepatocellular Carcinoma Targeted Thermosensitive Cu2+ Liposomes Based on the Cuproptosis Mechanism
This study develops galactose‐modified thermosensitive liposomes loaded with copper ions for the treatment of hepatocellular carcinoma. Combined with local tumor hyperthermia, this system delivers copper ions into tumor cells, induces cuproptosis by regulating FDX1 and DLAT expression and disrupting ROS/NADPH homeostasis, and suppresses tumor ...
Hao Yang +10 more
wiley +1 more source
Role of prostaglandin release in the response of tight epithelia to Ca2+ ionophores
We have studied the effects of the Ca2+ ionophores A23187 and ionomycin on ion transport across amphibian skin and urinary bladder. Both A23187 and ionomycin stimulated transepithelial Na+ transport across the skin.
D. Erlij +3 more
core +1 more source
ABSTRACT Withania somnifera (L.) Dunal (WS), commonly known as Ashwagandha, is a prominent medicinal herb in Ayurveda, with extensive therapeutic potential attributed to its diverse phytochemical profile. This review critically examines the immunomodulatory properties of WS, focusing on innate immune cell populations, including neutrophils, eosinophils,
Rana Yukta +9 more
wiley +1 more source
ATP Release and Purinergic Signaling Potentiate β‐Adrenergic Effects on Brown Adipocytes
ABSTRACT Aim Brown adipose tissue (BAT) specializes in energy consumption and thermogenesis in response to cold stress. Brown adipocytes (BA) express purinergic receptors, yet little is known about the source of extracellular ATP and the role of purinergic signaling, and the potential interaction with β‐adrenergic signaling.
Marco Tozzi +8 more
wiley +1 more source

