Results 101 to 110 of about 4,244,479 (353)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Dimethyl sulfoxide solvates of the aluminium(III), gallium(III) and indium(III) ions. A crystallographic, EXAFS and vibrational spectroscopic study [PDF]

, 2003
The isostructural hexakis( dimethyl sulfoxide)-aluminium(III), -gallium(III) and -indium(III) iodides crystallise in the trigonal space group R(3) over bar ( no. 148), Z = 3, at 295 +/- 1 K.
Kritikos, M., Skripkin, M., Mink, János, Molla-Abbassi, A., Molla-Abbassi, Alireza, Mink, Ja´nos, Sandström, Magnus, Skripkin, Mikhail, Persson, Ingmar,, Kritikos, Mikael   +9 more
core   +1 more source

Vagus nerve electroneurogram-based detection of acute kainic acid induced seizures

Frontiers in Neuroscience
Seizures produce autonomic symptoms, mainly sympathetic but also parasympathetic in origin. Within this context, the vagus nerve is a key player as it carries information from the different organs to the brain and vice versa.
Elena Acedo Reina, Enrique Germany Morrison, Enrique Germany Morrison, Ayse S. Dereli, Elise Collard, Romain Raffoul, Antoine Nonclercq, Riëm El Tahry, Riëm El Tahry, Riëm El Tahry   +9 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Ultrafast selective transport of alkali metal ions in metal organic frameworks with subnanometer pores

Science Advances, 2018
Subnanometer metal organic framework pores can selectively transport alkali metal ions of the same valence and similar sizes. Porous membranes with ultrafast ion permeation and high ion selectivity are highly desirable for efficient mineral separation ...
Hua-Cheng Zhang, Jue Hou, Yao-Xin Hu, Peiyao Wang, Ran-Wen Ou, Lei Jiang, J. Z. Liu, B. Freeman, A. Hill, Huan-Ting Wang   +9 more
semanticscholar   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Metal Ions in Bio-Imaging Techniques Metal Ions in Life Sciences Ser.

, 2021
Description based upon print version of record.Includes bibliographical references and index.Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between ...
Freisinger Eva., Sigel Roland K. O., Sigel Astrid.   +2 more
core  

The Development of Ionophore-Selective Based optical chemical sensors for the determination of heavy metal ions in aqueous environments [PDF]

, 2010
The development of optical sensors for in-situ, real-time and low-cost monitoring of heavy metal ions is a tremendously and fast growing area of research.
Li, Li
core   +2 more sources

Lymph flow, ionic and biochemical indicators of lymph and blood during hypoxia [PDF]

Brazilian Journal of Biology
In this study, the biochemical parameters and physico-chemical reactions of the body in experimental hypoxia, using a Sprague Dawley Rat Model. Hypoxia changed the dynamics and biochemical parameters of blood and lymph, as well as urine.
S. N. Abdreshov, G. A. Demchenko, U. N. Kozhaniyazova, A. N. Yeshmukhanbet, M. A. Yessenova, B. A. Nurmakhanova, R. M. Karjaubaev, L. U. Koibasova   +7 more
doaj   +1 more source