Results 101 to 110 of about 1,421,795 (306)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Metals, microbes, and minerals: the biogeochemical side of life Metal ions in life sciences ;, v.21.
, 2021 Includes bibliographical references and index.Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes; in ...
Sosa Torres Martha E., +1 more
core
The Development of Ionophore-Selective Based optical chemical sensors for the determination of heavy metal ions in aqueous environments [PDF]
, 2010 The development of optical sensors for in-situ, real-time and low-cost monitoring of heavy metal ions is a tremendously and fast growing area of research.
Li, Li
core +2 more sources
Optimization of Nd-Doped LMA Fibers for High-Power Laser Emission Near 915 nm
IEEE Photonics JournalWe report on the development of low numerical aperture (NA) Nd-doped large mode area (LMA) fibers with optimized core/clad geometry to achieve high-power laser emission near 915 nm while maintaining near diffraction-limited output beam.
Raphael Florentin +8 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Experimental studies of exotic transitions in high-Z few-electron ions [PDF]
, 2009 A novel experimental approach for studying exotic transitions in few-electron high-Z ions was developed. In this approach, few-electron ions with selectively produced single K-shell holes are used for the investigation of the transition modes that follow
Trotsenko, Sergiy
core
, 2020 Tandem mass spectrometry has long been used as a tool to extract structural information from an analyte ion. However, the information obtained in a tandem mass spectrometry experiment is dependent on both the ion type subjected to activation and the type
David J Foreman (8477364)
core +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Nature CommunicationsHow does sensory experience shape the development of the visual brain? To answer this eluding question, we examine brain responses to visual categories in a rare group of cataract-reversal individuals who experienced a short transient period of early ...
Stefania Mattioni +11 more
doaj +1 more source