Results 111 to 120 of about 4,244,479 (353)
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
, 2020 Tandem mass spectrometry has long been used as a tool to extract structural information from an analyte ion. However, the information obtained in a tandem mass spectrometry experiment is dependent on both the ion type subjected to activation and the type
David J Foreman (8477364)
core +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Experimental studies of exotic transitions in high-Z few-electron ions [PDF]
, 2009 A novel experimental approach for studying exotic transitions in few-electron high-Z ions was developed. In this approach, few-electron ions with selectively produced single K-shell holes are used for the investigation of the transition modes that follow
Trotsenko, Sergiy
core
Where Do the Ions Reside in a Highly Charged Droplet? [PDF]
, 2019 Droplets in atmospheric and electrosprayed aerosols carry more often than less, a multitude of ions. We address the question of the location of a collection of ions in charged aqueous droplets with linear dimensions in the nanometerrange using atomistic ...
Anatoly, Malevanets +2 more
core +2 more sources
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Catch and relay: brighter near-infrared photoluminescence in lanthanide-based nanoparticles
Light: Science & ApplicationsA design strategy for NIR-emitting lanthanide nanoparticles resolves the fundamental tension between core-shell passivation and dye sensitization. By engineering a Yb³⁺-doped interlayer as an active energy relay between surface-bound ICG and an heavily ...
Liyan Ming, Riccardo Marin
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source