Results 71 to 80 of about 2,476,585 (264)

Symmetries in Celestial CFT d

open access: yesJournal of High Energy Physics, 2023
We use tools from conformal representation theory to classify the symmetries associated to conformally soft operators in celestial CFT (CCFT) in general dimensions d.
Yorgo Pano   +2 more
doaj   +1 more source

Resource management in IP-based radio access networks [PDF]

open access: yes, 2001
IP is being considered to be used in the Radio Access Network (RAN) of UMTS. It is of paramount importance to be able to provide good QoS guarantees to real time services in such an IP-based RAN.
El Allali, H., Heijenk, G.
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

POLÍTICA NACIONAL DE RESÍDUOS SÓLIDOS E SUA GESTÃO NOS MUNICÍPIOS DO LITORAL NORTE DO ESTADO DE SÃO PAULO

open access: yesRevista UniVap, 2019
Este artigo tem como objetivo a análise das políticas públicas voltadas ao sistema de coleta e destinação dos resíduos sólidos urbanos na região do Litoral Norte do Estado de São Paulo, composta pelos municípios de Caraguatatuba, Ilhabela, São Sebastião ...
Eliete Gianini de Oliveira   +2 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Consideraciones para la selección de sistemas de información contables y administrativos en la Pyme colombiana

open access: yesEntramado, 2008
En la selección de Sistemas de Información Contables y Administrativos para la PyME, se debe tener en cuenta tres aspectos básicos, el funcional, el técnico y la metodología de implementación, definidos de la siguiente manera: 1.El aspecto funcional, es ...
Marco Tulio Astudillo Cerón
doaj  

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

open access: yesFEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli   +9 more
wiley   +1 more source

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