Results 41 to 50 of about 179,047 (302)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Address Configuration Scheme for All-IP Vehicular Network Based on Hierarchical Mechanism [PDF]
Jisuanji gongcheng, 2020 To address the problem that the speed of vehicle nodes affects the stability of IPv6 vehicular network,this paper proposes an address configuration scheme for all-IP vehicular network.
LI Yanli, WANG Xiaonan
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
The Value of Geographic Locations Submitted by Internet Users
IEEE Access, 2018 Internet users may be asked to manually provide their contact details, including city or full postal address. Examples include use of trial/free applications and services, filling out on-line surveys and petitions, and membership registration to loyalty ...
Dan Komosny, Miralem Mehic
doaj +1 more source
Fast and Scalable IP Address Lookup with Time Complexity of LogmLogm(n)
Journal of Advances in Information Technology, 2014 Router is a device which is used to route the incoming data packets from the sender to the destination using the IP address of the destination side.
Abhishant Prakash, Alok Sagar Gautam
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Arquitetura para ganho de eficiência energética em redes de sensores sem fios de próxima geração [PDF]
, 2008 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Ciência da Computação.A Nova Geração de Redes de Sensores Sem Fios irá integrar sistemas de comunicação além terceira geração.
Zimmermann, André
core
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source