Results 101 to 110 of about 2,090 (184)

Retinal glia regulate development of the circadian photoentrainment circuit

Cell Reports
Summary: Circadian photoentrainment depends on intrinsically photosensitive retinal ganglion cells (ipRGCs), which convey environmental light information to the hypothalamus.
Thomas W. Brown, Noemie Vilallongue, Sarah C. Hales, Shashank Srikanta, Pierre-Luc Rochon, Aline Giselle Rangel Olguin, Sebastián Boy Waxman, Adele Tufford, Jeremie Van Prooijen, Arjun Krishnaswamy, Nicolas Cermakian, Michel Cayouette   +11 more
doaj   +1 more source

Regulation of Reentrainment Function Is Dependent on a Certain Minimal Number of Intact Functional ipRGCs in rd Mice

Journal of Ophthalmology, 2017
Purpose. To investigate the effect of partial ablation of melanopsin-containing retinal ganglion cells (mcRGCs) on nonimage-forming (NIF) visual functions in rd mice lacking rods. Methods.
Jingxue Zhang, Huaizhou Wang, Shen Wu, Qian Liu, Ningli Wang   +4 more
doaj   +1 more source

Taurine Depletion Causes ipRGC Loss and Increases Light-Induced Photoreceptor Degeneration

Investigative Opthalmology & Visual Science, 2018
To examine if light exposure exacerbates retinal neuronal loss induced by taurine depletion.Albino rats received β-alanine in the drinking water to induce taurine depletion. One month later, half of the animals were exposed to white light (3000 lux) continuously for 48 hours and the rest remained in normal environmental conditions.
García-Ayuso, Diego, Pierdomenico, Johnny Di, Hadj-Said, Wahiba, Marie, Mélanie, Agudo-Barriuso, Marta, Vidal-Sanz, Manuel, Picaud, Serge, Villegas-Pérez, María   +7 more
openaire   +3 more sources

The Ins and Outs of Melanopsin Signaling [PDF]

, 2020
Intrinsically photosensitive retinal ganglion cells (ipRGCs) are responsible for non-image-forming functions such as circadian photoentrainment, pupillary light reflex and the suppression of melatonin.
Harrison, Krystal
core   +1 more source

Physiological mechanisms of the retinohypothalamic pathway in photophobia and the impact of intrinsically photosensitive retinal ganglion cells in migraine: a systematic review

Headache Medicine
Introduction Photophobia is the second most debilitating symptom of migraine. Intrinsically photosensitive retinal ganglion cells (ipRGCs), which express melanopsin, mediate this sensitivity by integrating intrinsic signals with those from cones and ...
João Gabriel Dantas, Eduardo Santana Fernandes Filho, Maria Eduarda Silva Guimarães, Alberto de Faria Santana, Clarissa da Paixão Barboza Salgado, Ana Ariel Santos Aragão, José Roberto Menezes Neto, João Bosco da Costa Filho, Rayan Oliveira Falcão, Ana Luiza Conceição Carvalho, Giulia Carolinne Santos Gonçalves, Humberto Fábio Nunes de Oliveira Filho, Renan Guedes de Brito, Yasmin Gabriele Ferreira Santos, Bruna Mendonça Doria de Jesus   +14 more
doaj   +2 more sources

Light-dependent pathways for dopaminergic amacrine cell development and function

eLife, 2018
Retinal dopamine is a critical modulator of high acuity, light-adapted vision and photoreceptor coupling in the retina. Dopaminergic amacrine cells (DACs) serve as the sole source of retinal dopamine, and dopamine release in the retina follows a ...
Teona Munteanu, Katelyn J Noronha, Amanda C Leung, Simon Pan, Jasmine A Lucas, Tiffany M Schmidt   +5 more
doaj   +1 more source

A subset of ipRGCs regulates both maturation of the circadian clock and segregation of retinogeniculate projections in mice

eLife, 2017
The visual system consists of two major subsystems, image-forming circuits that drive conscious vision and non-image-forming circuits for behaviors such as circadian photoentrainment. While historically considered non-overlapping, recent evidence has uncovered crosstalk between these subsystems. Here, we investigated shared developmental mechanisms. We
Kylie S Chew, Jordan M Renna, David S McNeill, Diego C Fernandez, William T Keenan, Michael B Thomsen, Jennifer L Ecker, Gideon S Loevinsohn, Cassandra VanDunk, Daniel C Vicarel, Adele Tufford, Shijun Weng, Paul A Gray, Michel Cayouette, Erik D Herzog, Haiqing Zhao, David M Berson, Samer Hattar   +17 more
openaire   +4 more sources

Comparison of the circadian response of intrinsic ipRGC and cone inputs to the post-illumination pupil response (PIPR) with salivary melatonin.

, 2013
Symbols (n = 11 participants; mean ± s.e.m) and lines (mean skewed baseline cosine function; Eq 1) encode intrinsic ipRGC (blue) and cone inputs (red) to the ipRGC controlled PIPR and
Emma L. Markwell (354804), Simon S. Smith (354802), Andrew J. Zele (354800), Beatrix Feigl (354801)   +3 more
core   +1 more source

Review on the role of intrinsically photosensitive retinal ganglion cells in the onset and progression of mental disorders

Shanghai Jiaotong Daxue xuebao. Yixue ban
The retina is the peripheral sensor of light information and the only part of the central nervous system accessible to direct observation. It is also regarded as a “window to the brain” due to its developmental and structural similarity to the brain ...
JIA Chenxi, ZHU Jiayi, DU Jiang, ZHAO Min   +3 more
doaj   +1 more source

Post-illumination pupil response (488 nm) amplitude and timing derived from individual participant models (n = 11), melatonin onset and peak time.

, 2013
*Threshold decrease in ipRGC activity defined as 0.01 mm rise above baseline PIPR model value.**Melatonin onset set to 14:00 h.
Emma L. Markwell (354804), Simon S. Smith (354802), Andrew J. Zele (354800), Beatrix Feigl (354801)   +3 more
core   +1 more source