Results 81 to 90 of about 2,090 (184)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, Volume 600, Issue 6, Page 837-846, March 2026.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Relationship between Daytime Sleepiness and Intrinsically Photosensitive Retinal Ganglion Cells in Glaucomatous Disease

Journal of Ophthalmology, 2016
Patients with glaucoma showed to have higher daytime sleepiness measured by Epworth sleepiness scale. In addition, this symptom was associated with pupillary reflex and polysomnography parameters.
Carolina P. B. Gracitelli, Gloria Liliana Duque-Chica, Ana Laura de Araújo Moura, Marina Roizenblatt, Balazs V. Nagy, Geraldine Ragot de Melo, Paula Delegrego Borba, Sérgio H. Teixeira, Sergio Tufik, Dora Fix Ventura, Augusto Paranhos   +10 more
doaj   +1 more source

Light Therapy Alleviates Addiction‐Related Symptoms and Reshapes Habenula and Midbrain Pathways

Advanced Science, Volume 13, Issue 13, 3 March 2026.
This study investigates light therapy for treating Internet Gaming Disorder (IGD). Functional MRI (fMRI) data reveal that light therapy enhances brain connectivity, particularly between the habenula and the medial orbitofrontal cortex (mOFC). These changes are associated with reduced withdrawal symptoms and addiction severity, highlighting the ...
Jinhui Li, Huiyang Huang, Cunhao Hu, Xuan Zhang, Song Lin, Xiaodan Huang, Ti‐fei Yuan, Kwok‐Fai So, Lu Huang, Chaoran Ren, Qian Tao   +10 more
wiley   +1 more source

Colorimetric and Photobiological Properties of Light Transmitted Through Low-Vision Filters: Simulated Potential Impact on ipRGCs Responses Considering Crystalline Lens Aging

Life
This study aims to investigate the potential impact of commercial low-vision filters on intrinsically photosensitive retinal ganglion cells (ipRGCs), which have significantly advanced our understanding of non-image-forming visual functions.
Ana Sanchez-Cano, Elvira Orduna-Hospital, Justiniano Aporta   +2 more
doaj   +1 more source

Post‐Translational Modifications in Animal Circadian Clocks

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Circadian clocks coordinate physiology with daily environmental cycles through conserved transcriptional–translational feedback loops. This review summarizes how post‐translational modifications fine‐tune clock function, highlights the evolutionary convergence of circadian timekeeping in Drosophila and mammals, and emphasizes the central of these ...
Xianhui Liu, Yong Zhang
wiley   +1 more source

Chemogenetic Activation of ipRGCs Drives Changes in Dark-Adapted (Scotopic) Electroretinogram

Investigative Opthalmology & Visual Science, 2016
The purpose of this study was to investigate the impact of activating melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) on dark-adapted (scotopic) electroretinograms (ERG).We used mice (Opn4Cre/+) expressing cre recombinase in melanopsin-expressing cells for a targeted gene delivery of a chemogenetic Gq-coupled receptor,
Nina Milosavljevic, Annette E. Allen, Jasmina Cehajic-Kapetanovic, Robert J. Lucas   +3 more
openaire   +3 more sources

Linking Photophobia, Sleep Disturbances, and Migraine Chronicity: Evidence From a Retrospective Analysis

Brain and Behavior, Volume 16, Issue 3, March 2026.
This study demonstrated that ictal photophobia was present in 89.8% and interictal photophobia in 93.4% of patients. Sleep disturbances were common, with 44.9% reporting difficulty falling asleep. Network analysis revealed stronger associations between interictal photophobia, daytime sleepiness, and medication overuse in chronic migraine compared to ...
Seden Demirci, Ezgi Uludüz, Sevim Eyüboğlu, Fatma Yardibi, Damla Hazal Sucu, Utku Topbaş, Aynur Özge, Derya Uludüz   +7 more
wiley   +1 more source

Distinct ipRGC subpopulations mediate light's acute and circadian effects on body temperature and sleep

eLife, 2018
The light environment greatly impacts human alertness, mood, and cognition by acute regulation of physiology and indirect alignment of circadian rhythms. Both processes require the melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), but the relevant downstream brain areas remain elusive.
Alan C Rupp, Michelle Ren, Cara M Altimus, Diego C Fernandez, Melissa Richardson, Fred Turek, Samer Hattar, Tiffany M Schmidt   +7 more
openaire   +3 more sources

Digital Sleep Disruption: Unraveling the Network Structure of Technology Use and Sleep Problems Through Network Analysis

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
In 9443 Chinese adults, network analysis reveals blue light exposure as the central factor most strongly associated with sleep problems (r = 0.31). General screen time shows minimal direct effects (r = 0.03), with sleep disruption mediated through evening‐specific behaviors.
Haoqing Gan, Lingjia Xu, Chenglin Tong
wiley   +1 more source

Subjective time expansion with increased stimulation of intrinsically photosensitive retinal ganglion cells

Scientific Reports, 2018
Intrinsically photosensitive retinal ganglion cells (ipRGCs) contain photoreceptors that are especially sensitive to blue light. Nevertheless, how blue light and ipRGCs affect time perception remains unsolved. We used the oddball paradigm and manipulated
Pei-Ling Yang, Sei-ichi Tsujimura, Akiko Matsumoto, Wakayo Yamashita, Su-Ling Yeh   +4 more
doaj   +1 more source