Results 61 to 70 of about 2,090 (184)

Identification of the synapse between an ipRGC and a putative ON cone bipolar cell in the IPL.

, 2012
A: A low magnification electron micrograph shows the relationship between a labeled ipRGC dendrite (asterisk) and an unlabeled axon of a putative ON bipolar cell (BCAX), which is running vertically through the INL and sublamina a of the IPL.
Jung-Il Moon (112244), Tae-Hyung Koo (112240), Eojin Jeong (112242), Hong-Lim Kim (112238), U-Young Lee (112241), In-Beom Kim (112246), Myung-Hoon Chun (112243), Stephen C. Massey (112245), Ji Hyun Jeon (112239)   +8 more
core   +1 more source

Blue Light Exposure During Sleep in Type 1 Diabetes: Impacts on Glycemic Control and Psychosocial Health

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Light exposure at night is linked to increased risk for obesity and insulin resistance in the general population. While sleep health is recognized as a key component of diabetes management, there has been less emphasis on nighttime light exposure. This study aimed to investigate the effects of blue and white light exposure immediately prior to
Seok Jin Hong, Sarida Pratuangtham, Pamela Martyn‐Nemeth, Alana D. Steffen, Chang Gi Park, Sirimon Reutrakul   +5 more
wiley   +1 more source

Intrinsically photosensitive retinal ganglion cell function in relation to age: A pupillometric study in humans with special reference to the age-related optic properties of the lens

BMC Ophthalmology, 2012
Background The activity of melanopsin containing intrinsically photosensitive ganglion retinal cells (ipRGC) can be assessed by a means of pupil responses to bright blue (appr.480 nm) light. Due to age related factors in the eye, particularly, structural
Herbst Kristina, Sander Birgit, Lund-Andersen Henrik, Broendsted Adam, Kessel Line, Hansen Michael, Kawasaki Aki   +6 more
doaj   +1 more source

The Intrinsically Photosensitive Retinal Ganglion Cell (ipRGC) Pathway and Its Role in Light-Induced Discomfort in Humans [PDF]

, 2018
Photophobia is a complex phenomenon defined by light-driven painful sensations; commonly associated with pathology. Although underlying mechanisms remain poorly understood and no objective assessment exists, growing evidence suggests that the melanopsin ...
Zivcevska, Marija
core  

Data_Sheet_1_Colour and melanopsin mediated responses in the murine retina.docx

, 2023
Introduction: Intrinsically photosensitive retinal ganglion cells (ipRGCs) integrate melanopsin and rod/cone-mediated inputs to signal to the brain. Whilst originally identified as a cell type specialised for encoding ambient illumination, several lines ...
Robert J. Lucas (8665689), Joshua W. Mouland (14781373), Alex J. Watson (14781376), Timothy M. Brown (12256890), Franck P. Martial (7671194)   +4 more
core   +1 more source

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, Volume 2, Issue 3, September 2026.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source

Quantitative characterisation of ipRGCs in retinal degeneration using a computation platform for extracting and reconstructing single neurons in 3D from a multi-colour labeled population

Frontiers in Cellular Neuroscience, 2022
Light has a profound impact on mammalian physiology and behavior. Intrinsically photosensitive retinal ganglion cells (ipRGCs) express the photopigment melanopsin, rendering them sensitive to light, and are involved in both image-forming vision and non ...
Christopher A. Procyk, Jessica Rodgers, Egor Zindy, Robert J. Lucas, Nina Milosavljevic   +4 more
doaj   +1 more source

Seasonal variation in neurohormones, mood and sleep in patients with primary open angle glaucoma - implications of the ipRGC-system

, 2021
Primary open angle glaucoma is associated with an increased risk of mood and sleep disorders. These adversities have been suggested to relate to a disrupted function of the intrinsically photosensitive retinal ganglion cells (ipRGCs).
Martiny, Klaus, Madsen, Helle Ostergaard, Hageman, Ida, Ba-Ali, Shakoor, Lund-Andersen, Henrik, Kolko, Miriam, Miriam Kolko, Henrik Lund-Andersen, Ida Hageman, Shakoor Ba-Ali, Helle Østergaard Madsen, Klaus Martiny   +11 more
core   +1 more source

ENLIGHTENme: Translating the Benefits of Self‐Administered Daytime Light Supplementation to Older Adults in the Real World

Journal of Pineal Research, Volume 78, Issue 5, September 2026.
ABSTRACT Controlled studies have demonstrated that light supplementation benefits circadian entrainment, sleep and mood. Translating these findings into effective, real‐world usage of light supplementation is, however, challenging because naturalistic and supplemental light exposure are shaped by personal habits and environmental light conditions ...
Débora B. Constantino, Flavia Baccari, Leonardo Caporali, Valerio Carelli, Giulia Amore, Marijke Gordijn, Toomas Haller, Chiara La Morgia, Anne Landvreugd, Marina Marinelli, David McDaid, Monika Nõmm, Francesco Nonino, Martina Romagnoli, Martino Schettino, Corrado Zenesini, Meike Bartels, Debra J. Skene, Daan R. van der Veen   +18 more
wiley   +1 more source

Mathematical Modeling of Melanopsin's Light Response in ipRGCs and Hek Cells [PDF]

Biophysical Journal, 2015
Melanopsin is an unusual vertebrate photopigment that, in mammals, is expressed in a small subset of intrinsically photosensitive retinal ganglion cells (ipRGCs), whose signaling has been implicated in non-image forming vision, regulating such functions as circadian rhythms, pupillary light response, and sleep.
Robinson, Phyllis R., Jackson, Abigail, Ortega, Jessica, Kang, Hyewon, Hoffman, Kathleen   +4 more
openaire   +1 more source