Results 161 to 170 of about 2,090 (184)
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Spatial distribution and functional integration of displaced ipRGCs
2023Abstract The mammalian retina contains many distinct types of ganglion cells, which form mosaics to evenly tile the retina with cells of each type at each position of the visual field. It is well known that displaced retinal ganglion cells (dRGCs) exist with cell bodies in the inner nuclear layer, along with regularly placed RGCs with ...
Sabrina Duda +5 more
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Melanopsin activates divergent phototransduction pathways in ipRGC subtypes
2022Abstract Melanopsin signaling within ipRGC subtypes impacts a broad range of behaviors from circadian photoentrainment to conscious visual perception. Yet, how melanopsin phototransduction within M1-M6 ipRGC subtypes impacts cellular signaling to drive diverse behaviors is still largely unresolved.
Ely Contreras +3 more
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Influence of ipRGC activation on retinal physiology
2023The intrinsically photosensitive retinal ganglion cells (ipRGCs) are photoreceptors in the mammalian retina expressing the photopigment melanopsin. Upon light activation ipRGCs signal light information to the brain either via an intrinsic light response or acting as conduits for rod and cone light responses.
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The cognitive impact of light: illuminating ipRGC circuit mechanisms
Nature Reviews NeuroscienceEver-present in our environments, light entrains circadian rhythms over long timescales, influencing daily activity patterns, health and performance. Increasing evidence indicates that light also acts independently of the circadian system to directly impact physiology and behaviour, including cognition. Exposure to light stimulates brain areas involved
Heather L. Mahoney, Tiffany M. Schmidt
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Pupillary responses driven by ipRGCs and classical photoreceptors are impaired in glaucoma
Graefe's Archive for Clinical and Experimental Ophthalmology, 2016The aim was to investigate the involvement of intrinsically photosensitive retinal ganglion cells (ipRGCs) in patients with manifest glaucoma and ocular hypertension (OH) using specific parameters of the pupil light reflex to chromatic stimuli.Twenty-five patients with manifest glaucoma, 16 patients with OH and 16 healthy control subjects were ...
Carina, Kelbsch +6 more
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EFFECT OF IPRGC STIMULATION ON CONTRAST SENSITIVITY IN CENTRAL VISION
CIE x051:2025 Proceedings of the CIE 2025 Midterm Meeting Vienna, Austria, July 4-11, 2025: Scientific Conference (July 7-9, 2025)Since the discovery of the intrinsically photosensitive retinal ganglion cells (ipRGCs), their roles have been investigated by vision researchers around the world, and their effects on non-image-forming functions, such as circadian rhythm and pupillary light reflex, are now being evaluated.
Hiroshi Takahashi +4 more
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ipRGC Properties Prevent Light From Shifting the SCN Clock During Daytime
NatureThe suprachiasmatic nucleus (SCN), the central circadian pacemaker, receives photic input exclusively from intrinsically photosensitive retinal ganglion cells (ipRGCs)1,2. However, light mainly shifts the SCN clock during night-time3-5. Here we induced phase shifts in the SCN clock during the daytime in mice by activating ipRGCs using chemogenetics or ...
Michael H Berry +2 more
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PACAP/PAC 1 modulates light-induced sleep via the ipRGC-VLPO pathway
Biochemical and Biophysical Research CommunicationsLight can induce sleep. Many studies have shown that intrinsically photosensitive retinal ganglion cells (ipRGCs) and the ventrolateral preoptic area (VLPO) pathway mediate light-induced sleep. IpRGCs can release the pituitary adenylate cyclase-activating peptide (PACAP), which is involved in the regulation of circadian rhythm.
Weipeng Wang +8 more
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