Results 161 to 170 of about 59,237 (269)

Differential Neuronal Development in iPSC-Derived Neural Stem Cells From Monozygotic Twin Cases With Treatment-Resistant Schizophrenia and Discordant Responses to Clozapine. [PDF]

Neuropsychopharmacol Rep
Kawano S, Katayama S, Ogawa M, Endo R, Ikeda N, Ikeuchi Y, Mita T, Takei H, Gotoda-Nishimura N, Miura D, Fukushima H, Hashimoto H, Hashimoto R, Nakazawa T.   +13 more
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Organic photonic synaptic transistors for bionic vision: From spectral engineering to flexible intelligent perception

FlexMat, EarlyView.
Different wavelength photonic synapses are used for biomimetic visual applications. Abstract Bionic intelligent visual perception systems have significant application prospects in fields such as autonomous driving and robotics, medical imaging and auxiliary diagnosis, security and monitoring.
Longlong Jiang, Shan Wu, Silu Feng, Heyi Huang, Wangyu Wu, Hong Han, Yao Ni   +6 more
wiley   +1 more source

iPSC-derived exosomes promote diabetic wound healing by attenuating inflammatory responses. [PDF]

Stem Cell Res Ther
Long L, Qiao J, Wang L, Wang Y, Xu Y, Chen H, Jin H, He W, Han X, Zhang J.   +9 more
europepmc   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Editorial Note: On the utilization of the induced pluripotent stem cell (iPSC) model to study substance use disorders: A scoping review protocol. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Emerging Human‐Based Research Technologies for Investigating the Pathomechanisms and Therapies for Vascular Diseases

iNew Medicine, EarlyView.
ABSTRACT It is estimated that a large proportion of drug candidates fail in human clinical trials, mainly because animal models cannot fully replicate human disease and because of differential responses to various medications between humans and animals.
Weiping Ding, Iqra Ilyas, Suowen Xu
wiley   +1 more source

Modeling CLN3 Batten disease in astrocytes reveals alterations in mitochondria homeostasis, fatty acid metabolism and oxidative stress response. [PDF]

J Biomed Sci
Yang M, Wang W, Cámara-Quílez M, Farsund BH, Andersen NN, Garten K, Sharma A, Lin X, Åmellem I, Ravlo E, Ye J, Bjørås M, de Sousa MML.   +12 more
europepmc   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Revisiting viral reprogramming: Measles virus as a robust platform for high-quality iPSC generation. [PDF]

Mol Ther Adv
Moutaoufik MT, Chahine M.
europepmc   +1 more source