Results 181 to 190 of about 88,697 (303)

Integrated Multiomic Analysis Reveals an EBV‐Associated MIF–SPP1+ Macrophage Axis Linking Tumor Stemness and Immune Dysfunction in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
This study maps how Epstein–Barr virus reshapes the cellular ecosystem of nasopharyngeal carcinoma. It identifies SPP1+ macrophages as partners of stemness‐associated tumor cells and dysfunctional T cells, links tumor‐derived MIF to macrophage recruitment and programming, and shows that macrophage‐derived SPP1 promotes tumorsphere formation and impairs
Guo‐Ying Liu, Shu‐Hui Lv, Shui‐Qing He, Yao‐Fei Jiang, Xing‐Si Peng, Jian‐Cong Sun, Fen He, Hai‐Yan Qin, Nian Lu, Wei‐Xin Bei, Lin‐Yu Zhao, Wan‐Qin Shen, Ze‐Yu Zhao, Lin Wang, Yan‐Qun Xiang, Wang‐Zhong Li   +15 more
wiley   +1 more source

A Water Compartment Cell Culture Lid Enables Stable Longitudinal Recording of Neuronal Networks In Vitro

Advanced Science, EarlyView.
A cell culture lid with an integrated water compartment eliminates evaporation from microelectrode arrays while preserving gas exchange. Freed from the osmotic drift and repeated medium exchanges that disturb conventional recordings, patterned human iPSC‐derived neuronal networks are recorded continuously for five weeks. Single‐spike resolution reveals
Benedikt Maurer, Fabio Fischer, Giulia Amos, Vaiva Vasiliauskaitė, János Vörös   +4 more
wiley   +1 more source

ALDH2 Deficiency Promotes Mitochondrial Oxidative Stress and Adverse Limb Outcomes via VDAC–HSP60 Signaling

Advanced Science, EarlyView.
ALDH2 deficiency promotes 4‐HNE accumulation, resulting in covalent modification of HSP60, disruption of its oligomeric assembly, and VDAC1‐dependent release of HSP60 from mitochondria to the cytosol. Pharmacological activation of ALDH2 preserves HSP60 proteostasis and mitochondrial integrity, whereas the clinical association between the ALDH2 rs671 ...
You‐Cheng Lin, Nan‐Chun Wu, Chon‐Seng Hong, Po‐Chao Hsu, Wen‐Jin Yang, Yi‐Cheng Chang, Che‐Hong Chen, Wei‐Ting Chang   +7 more
wiley   +1 more source

Modulation of Endoplasmic Reticulum Stress via CEBPB: A Potential Molecular Link to Therapeutic Action in Substance Use Disorders. [PDF]

CNS Neurosci Ther
Zhang C, Li H, Ho MF.
europepmc   +1 more source

Hypoxic Preconditioning Restores NK Cell Metabolic Fitness by Attenuating MAPK Signaling to Potentiate Antitumor Immunity in Lung Cancer

Advanced Science, EarlyView.
Solid tumor hypoxia severely compromises natural killer cell function. This study demonstrates that hypoxic preconditioning preserves NK cell antitumor activity by limiting excessive stress ‐MAPK signaling and promoting mitochondrial metabolic fitness.
Dian Zhuang, Xiaoyue Zhu, Na Wang, Qianqian Liu, Lihua Chen, Yanzhuo Ye, Lingrui Shang, Shasha Huang, Cong Ma, Wei Kevin Zhang, Tao Xu, Jiaqi Sun, Huisheng Liu   +12 more
wiley   +1 more source

20 years of iPSCs: From cellular reprogramming to clinical translation. [PDF]

Cell Rep Med
Nitsche L, Panada E.
europepmc   +1 more source

Dual‐Mode Optoelectronic Synapse Based on Ultrathin InxTiyO Films for In‐Sensor Neuromorphic Computing and Physical Image Encoding

Advanced Electronic Materials, EarlyView.
An ultrathin InxTiyO‐based optoelectronic synaptic device enables dual‐mode electrical and optical synaptic responses through charge‐trapping‐mediated conductance modulation. Multilevel conductance states further enable physical image encoding, converting visual information into spatial current distributions.
Chaerin Yu, Jung Wook Lim
wiley   +1 more source

RBFOX2 Autoregulation Promotes Cardiomyocyte Transcriptome Maturation and Differentiation. [PDF]

Circ Res
Huang M, Ladha FA, Wang Y, Trembley MA, Yin HM, Zheng R, Prondzynski M, Tharani Y, Akerberg AA, Aigner S, Yee BA, Mayourian J, Morton SU, Bezzerides VJ, Pu WT, Yeo GW, Chen K, Burns CG, Burns CE.   +18 more
europepmc   +1 more source

A Generative AI Framework to Predict Cardiomyocyte Contraction Function From Single Static Images

Advanced Intelligent Discovery, EarlyView.
A single static hiPSC‐cardiomyocyte image is fed into a U‐Net‐GAN framework, which directly predicts a pixel‐resolved contraction heatmap without time‐lapse imaging. StyleGAN2‐generated synthetic cell–heatmap pairs augment training, improving prediction fidelity (SSIM = 0.84).
Andrew Kowalczewski, Chenyan Wang, Xinrui Wang, Huaxiao Yang, Zhao Qin, Zhen Ma   +5 more
wiley   +1 more source

Modeling Heart Failure With Preserved Ejection Fraction Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. [PDF]

Circulation
Yu B, Ren L, Liu Y, Tu C, Kojic A, Dai Y, Venkateshappa R, Shen M, Zhao SR, Wu JC.   +9 more
europepmc   +1 more source