Results 171 to 180 of about 116,955 (355)

Connexin 43‐Enriched Vesicles Improve Synchronization in hiPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Plasma membrane‐derived Connectosomes enriched in connexin‐43 are produced from donor hiPSCs and applied to hiPSC‐derived cardiomyocytes (hiPSC‐CMs). Connexin‐43 channels on Connectosomes remain functional, strengthening intercellular electrochemical coupling and increasing network synchronization over time.
Nima Momtahan, Anna K. McClain, Andrea Trementozzi, Sogu Sohn, Lingxia Qiao, Chi Zhao, Padmini Rangamani, Jeanne C. Stachowiak, Janet Zoldan   +8 more
wiley   +1 more source

Generation of Myeloid Lineage Cells from Induced Pluripotent Stems Cells (iPSCs) as Powerful Platform to Study Patients with CCR5Δ32 Mutation

, 2023
Guibin Chen, Francesca Calcaterra, Yuchi Ma, Xianfeng Ping, Elena Pontarini, Dan Yang, Ferdinando Oriolo, Zhen Yu, Assunta Cancellara, Joanna Mikulak, Yuting Huang, Silvia Della Bella, Yangtengyu Liu, Rebecca L. Harper, Clifton L. Dalgard, Manfred Boehm, Domenico Mavilio   +16 more
openalex   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Combination of induced pluripotent stem cell-derived motor neuron progenitor cells with irradiated brain-derived neurotrophic factor over-expressing engineered mesenchymal stem cells enhanced restoration of axonal regeneration in a chronic spinal cord injury rat model

Stem Cell Research & Therapy
Background Spinal cord injury (SCI) is a disease that causes permanent impairment of motor, sensory, and autonomic nervous system functions. Stem cell transplantation for neuron regeneration is a promising strategic treatment for SCI.
Jang-Woon Kim, Juryun Kim, Soon Min Lee, Yeri Alice Rim, Young Chul Sung, Yoojun Nam, Hyo-Jin Kim, Hyewon Kim, Se In Jung, Jooyoung Lim, Ji Hyeon Ju   +10 more
doaj   +1 more source

The Emerging Parkinson's Disease Oxylipin‐Ome

Advanced Science, EarlyView.
ABSTRACT Parkinson Disease (PD) is increasingly considered a proteinopathy and lipidopathy. This proteinopathy+lipidopathy paradigm has been further refined to a fatty acid (FA)‐opathy, centering dysregulated FA metabolism as fundamental in PD lipid dysfunction.
Julia C. Kelliher, Saranna Fanning
wiley   +1 more source

iPSC Cortical Differentiation v1 [PDF]

, 2019
Celeste M. Karch, Rita Martinez, Jacob Marsh   +2 more
openalex   +1 more source

A Dynamic 3D Human Liver Sinusoid Model for Mechanistic Interrogation of Fontan‐Associated Liver Disease

Advanced Science, EarlyView.
This study presents a perfusable 3D bioengineered liver sinusoid platform that integrates biofabrication, 3D cell culture, controlled hemodynamics, and multiparametric characterization to model Fontan‐associated liver disease. By decoupling pressure and hypoxia effects, the system reveals early mechanobiological and profibrotic responses under ...
Sarah Rezapourdamanab, Mehdi Salar Amoli, Tanmay Mukherjee, Maryam Bagheri, Boeun Hwang, Linqi Jin, Yamini Singh, Sophia Norton, Ashay Vishwas Bongirwar, Shweta Karnik, Lakshmi Prasad Dasi, Reza Avazmohammadi, Rene Romero, Holly D. Bauser‐Heaton, Vahid Serpooshan   +14 more
wiley   +1 more source

Generation of SLC45A1 Knockout iPSC Line (WTC11-Ngn2 Line) v1 [PDF]

Marc Gastou, Ali Ghoochani, Natalia Gomez-Ospina, Abu-Remaileh Monther   +3 more
openalex   +1 more source

iPSC-Astrocyte morphology reflects patient clinical markers [PDF]

, 2023
Helen Rowland, Georgina Miller, Qiang Liu, Nicola R Sharp, Bryan Ng, Liting Wei, Kanisa Arunasalam, Ivan Koychev, Anne Hedegaard, Elena M. Ribé, Dennis Chan, Tharani Chessell, Ece Kocagöncü, Jennifer Lawson, Paresh Malhotra, Basil H. Ridha, James B. Rowe, Alan Thomas, Giovanna Zamboni, Henrik Zetterberg, M. Zameel Cader, Richard Wade‐Martins, Simon Lovestone, Alejo Nevado‐Holgado, Andrey Kormilitzin, Noel J. Buckley   +25 more
openalex   +1 more source