Results 191 to 200 of about 116,955 (355)

Pigment epithelium-derived factor (PEDF) normalizes matrix defects in iPSCs derived from Osteogenesis imperfecta Type VI [PDF]

, 2016
Glenn S. Belinsky, Leanne M. Ward, Chuhan Chung   +2 more
openalex   +1 more source

Small molecule screen employing patient-derived iPSC hepatocytes identifies LRRK2 as a novel therapeutic target for Alpha1 Antitrypsin Deficiency [PDF]

, 2022
Deniz Kent, Soon Seng Ng, Payam Khoshkenar, Adam Syanda, Chao Zheng Li, Marina Zieger, Stephanie B. Hatch, Joe M. Segal, Samuel J.I. Blackford, Kaixing Le, V. Chowdary, Taylor Ismaili, Davide Danovi, Patrick A. Lewis, Sunil Sahdeo, Daniel Ebner, Christian Mueller, S. Tamir Rashid   +17 more
openalex   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Defined culture conditions improve functional properties of mature iPSC-derived macrophages for therapeutic screening. [PDF]

Stem Cell Res Ther
Schinke M, Gensch I, Rietschel T, Nguyen AHH, Slevogt H, Jänsch L, Lachmann N.   +6 more
europepmc   +1 more source

2nd International Plant Spectroscopy Conference (IPSC - 2019)

, 2019
Hartwig Schulz, Catharina Blank, Christoph Böttcher, Benjamin Fürstenau, Andrea Krähmer, Torsten Meiners, David Riewe   +6 more
openalex   +2 more sources

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

Liver developmental microenvironment promotes iHSC generation from human iPSCs [PDF]

Di Ye, Min Ding, Yu-Mu Song, Hengxing Meng, Wen‐Hao Chen, Jinshan Ge, Yun‐Wen Zheng   +6 more
openalex   +1 more source

Functional Correction of Large Factor VIII Gene Chromosomal Inversions in Hemophilia A Patient-Derived iPSCs Using CRISPR-Cas9 [PDF]

, 2015
Chul‐Yong Park, Duk Hyoung Kim, Jeong Sang Son, Jin Jea Sung, Jaehun Lee, Sangsu Bae, Jong‐Hoon Kim, Dong‐Wook Kim, Jin‐Soo Kim   +8 more
openalex   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Preclinical efficacy of combination therapy with allogeneic induced pluripotent stem cell-derived invariant natural killer T and α-galactosylceramide-pulsed antigen-presenting cells. [PDF]

Stem Cell Res Ther
Aoki T, Kobayashi M, Okoshi M, Yamaguchi M, Okura H, Sasaki S, Sasako Y, Kira S, Chang YH, Yakushiji-Kaminatsui N, Sharif J, Matsuda M, Kiuchi M, Hirahara K, Kimura MY, Motohashi S, Koseki H.   +16 more
europepmc   +1 more source