Results 211 to 220 of about 59,237 (269)

Comprehensive assessment of the genomic stability of human induced pluripotent stem cells for clinical applications. [PDF]

Stem Cell Res Ther
Zhang K, Na T, Jia C, Yuan X, Guo M, Yang X, Li M, Jia W, Bai Z, Lu J, Liu Z, Meng S.   +11 more
europepmc   +1 more source

CRYAB is compromised in pathologically affected oligodendrocytes in multiple system atrophy

Brain Pathology, EarlyView.
CRYAB is hypermethylated and colocalizes with α‐synuclein in multiple system atrophy oligodendrocytes.
Finula I. Isik, Jen‐Hsiang T. Hsiao, Felicia Xaveria Suteja, Shrey Shahdadpuri, Nicolas Dzamko, Glenda M. Halliday, Woojin Scott Kim, YuHong Fu   +7 more
wiley   +1 more source

Paracrine Induction of Cardiomyogenic Differentiation in Patient-Specific MSCs Using Conditioned Medium from iPSC-CMs. [PDF]

Biomedicines
Litvinenko V, Alkhateeb R, Romanova S, Kovalenko S, Dzhabrailov V, Popov MA, Slotvitsky M, Agafonov EG, Dontsov VV, Frolova S, Zybin DI, Shumakov DV, Romanov A, Agladze K, Tsvelaya VA.   +14 more
europepmc   +1 more source

Selective modulation of NaV channel gating counteracts aberrant hyperexcitability and rescues motor function and survival in a model of spinal muscular atrophy

British Journal of Pharmacology, EarlyView.
Background and Purpose Spinal muscular atrophy (SMA) is a motor neuron disease caused by SMN1 gene loss, leading to reduced survival motor neuron (SMN) protein and progressive motor neuron degeneration. Although SMN‐restoring therapies improve outcomes, residual disease burden and non‐curative efficacy underscore the need for complementary treatments ...
Fernanda C. Cardoso, Jessica A. I. Muller, Yougang Zhang, Jean Giacomotto   +3 more
wiley   +1 more source

Generation of the RCPCMi014-A and RCPCMi014-B lines from T-lymphocytes of a healthy donor and verification of their monoclonal origin by TCR V(D)J rearrangement analysis. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Sherman DK, Bogomiakova ME, Kastueva EA, Zvyagin IV, Ruppel VK, Barsova EV, Gorbachev AY, Kulemin NA, Barinova AA, Zerkalenkova EA, Bogomazova AN, Lagarkova MA.   +11 more
europepmc   +1 more source

Splicing Factor Mutations in Clonal Hematopoiesis and Progression to Myeloid Neoplasms

Cancer Science, EarlyView.
Splicing factor (SF)‐mutant CH is characterized by relatively late emergence and accelerated clonal expansion in older individuals. This review summarizes its clonal dynamics, disease‐associated consequences of SF mutations in myeloid neoplasms, and candidate mechanisms that may contribute to age‐dependent selection.
Yang Lyu, Yutong Zhang, Ayana Kon
wiley   +1 more source

Efficient and reliable measles reprogramming platform for the generation of human iPSC. [PDF]

Mol Ther Adv
Vashistha S, Hoffer S, Dade J, Majerus S, Royster A, Caya C, Sharp B, Devaux P.   +7 more
europepmc   +1 more source

Decellularised Corneal Stromal Lamina With or Without Autologous Adipose‐Derived Adult Stem Cells for Advanced Keratoconus: 1‐Year Results of a Phase I/IIa Clinical Trial

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background To report the 1‐year clinical outcomes of decellularised human corneal stromal lamina implantation, with or without autologous adipose‐derived adult stem cells (ADASCs), for advanced keratoconus in a European cohort. Methods In this prospective, randomised Phase I/IIa trial, 10 eyes of 10 patients were allocated to decellularised ...
Hao Zhang, Jorge L. Alió del Barrio, Alejandra E. Rodriguez, Rafael I. Barraquer, Francisco Arnalich‐Montiel, David Mingo‐Botín, María Eugenia Fernández Santos, Jorge L. Alió   +7 more
wiley   +1 more source

Protocol for generating iPSC-derived intestinal organoids through dissection to model cystic fibrosis therapies. [PDF]

STAR Protoc
Stuffer AJ, Tabak B, Conte J, Momyer V, Chado M, Armstrong M, Wible P, Sivachenko A, Allaire N, Lu J, Mense M, Mahoney JE.   +11 more
europepmc   +1 more source