Results 211 to 220 of about 88,697 (303)

Cytoskeleton–Membrane Uncoupling in Duchenne Muscular Dystrophy: Implications for Newborn Screening and Early Protection

Cytoskeleton, EarlyView.
ABSTRACT The cytoskeleton of striated muscle integrates force transmission, mechanotransduction, and sarcolemmal stability through coordinated networks of sarcomeres, costameres, and intermediate filaments. Together, these systems establish mechanical continuity between the contractile apparatus, the sarcolemma, and the extracellular matrix.
Houda Cohen, Nora Hosny, Brian R. Thompson, Joseph M. Metzger   +3 more
wiley   +1 more source

Voices: What impact has iPSC technology had on your research and/or field? [PDF]

Stem Cell Reports
europepmc   +1 more source

Navigating Human Astrocyte Differentiation: Direct and Rapid One-Step Differentiation of Induced Pluripotent Stem Cells to Functional Astrocytes Supporting Neuronal Network Development. [PDF]

Glia
Schuurmans IME, Mordelt A, Guevara-Ferrer M, Linda K, Duineveld D, Puvogel S, Hommersom MP, Scheefhals N, Rahm L, Dyke E, Scholten GJ, Knorz C, Jimenez CG, van Egmond N, Oudakker A, Bijnagte-Schoenmaker C, van Bokhoven H, Wei W, Hofmann S, Jung-Klawitter S, Mojica-Perez S, Parent J, Carotenuto L, Weckhuysen S, Maas N, Elgersma Y, van de Ven E, Lefeber D, Lygeroudi A, de Vries HE, Jordi L, Polymenidou M, Mitchell-Garcia T, Dragan I, Dolga A, de Witte LD, van Karnebeek CDM, Ellis J, Garanto A, Nadif Kasri N.   +39 more
europepmc   +1 more source

Assembly and Maintenance of Myofibrils in the Heart

Cytoskeleton, EarlyView.
ABSTRACT The assembly of actin and myosin to the paracrystalline arrangement of myofibrils in striated muscle, that is, heart and skeletal, has puzzled many a cell biologist. Different models, based on cultured cardiomyocytes, were proposed for the last 30 years to explain the sequence of events.
Elisabeth Ehler
wiley   +1 more source

Editorial: The significance of induced pluripotent stem cells in translational medicine. [PDF]

Front Immunol
Alvarez-Palomo B, Skokowa J, Latsoudis H.   +2 more
europepmc   +1 more source

Hyperactive KIF5A in Neurodegeneration

Cytoskeleton, EarlyView.
ABSTRACT The highly polarised morphology of neurons and the sheer length of their axons make transport of cargoes throughout the cell a formidable task. Decades of evidence obtained from genetic studies on patients and animal models highlight deficits in axonal transport as a recurrent cause, or early contributing factor, in a plethora of ...
David Villarroel‐Campos, James N. Sleigh   +1 more
wiley   +1 more source

Clinical trials in a dish: cardiometabolic drug development with biological and digital twins. [PDF]

J Clin Invest
Patra D, Sayed IM, Venkateshappa R, Palaniappan L, McLaughlin T, Wu JC.   +5 more
europepmc   +1 more source

KIF1A‐Mediated Axonal Transport of Netrin‐1 in iPSC‐Derived Human Forebrain Neurons

Cytoskeleton, EarlyView.
ABSTRACT Netrin‐1 is a secreted laminin‐like protein that functions as a guidance cue for axon pathfinding in development. Netrin‐1 also modulates synapse formation in developing neurons and long‐term potentiation in mature neurons. Netrin‐1 is expressed in human neurons; however, its intracellular distribution and trafficking have not been assessed ...
T. Y. Leung, J. Sidhu, A. Hsieh, Y. Ma, J. Liu, M. A. Silverman   +5 more
wiley   +1 more source

Characterization of DNA methylation in PBMCs and donor-matched iPSCs shows age-related methylation is reset during stem cell reprogramming. [PDF]

PLoS One
Reed X, Weller CA, Saez-Atienzar S, Beilina A, Solaiman S, Portley M, Kaileh M, Roy R, Ding J, Moore AZ, Whitaker DT, Traynor BJ, Ferrucci L, Gibbs JR, Scholz SW, Cookson MR.   +15 more
europepmc   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source