Results 201 to 210 of about 88,697 (303)

From Somatic Cells to Offspring: iPSC-Based Gametogenesis for Animal Conservation and Livestock Production. [PDF]

Biology (Basel)
Khan I, Rungsiwiwut R, Thongphakdee A, Subboriboon S, Angchuan C, Samruan W, Khalil AAK, Parnpai R.   +7 more
europepmc   +1 more source

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source

3-Dimensional Human iPSC-Derived Cardiac Organoids for Antifibrotic Drug Screening. [PDF]

Circ Res
Zhang H, Huang R, Thai PN, Ren L, Shivnaraine RV, Zhu W, Dai Y, Liu W, Xie M, Liu X, Tan R, Yang X, Cao X, Wu X, Wu MA, Caridi C, Solow-Cordero D, Wu JC.   +17 more
europepmc   +1 more source

iPSC Generation

At Creative Bioarray, our iPSC Generation Services are enabled by our robust stem cell platform with several integration-free technologies such as Sendai virus, episomal plasmid and mRNA-based technologies. To ensure optimal results, we customize our reprogramming methods based on the initial cell type and the ultimate application, paying close ...
openaire   +1 more source

Regenerative perfusion bioreactor for biologics production with lower COGs

Biotechnology Progress, EarlyView.
Abstract Perfusion bioreactor systems enable intensified bioprocessing with high cell densities and volumetric productivities in monoclonal antibody (mAb) manufacturing. However, their widespread adoption remains constrained by the high consumption of chemically defined cell culture media.
Eric Wynne, Dohyun Park, Hourieh Ahi, Jaeweon Lee, Seongkyu Yoon, Jongyoon Han   +5 more
wiley   +1 more source

From consent to participatory governance: The need for multi-stakeholder alignment in iPSC-based drug repurposing. [PDF]

Stem Cell Reports
Bührman EAM, Geille A, Cornel MC, Boon WPC, Heine VM, Rigter T, SIMPATHIC Consortium.   +6 more
europepmc   +1 more source

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

Cell Village Captures Populational Heterogeneity of Sunitinib Cardiotoxicity. [PDF]

Circ Res
Kojic A, Liu Y, Belbachir N, Tu C, Shen M, Caudal A, Meharwade T, Belbachir M, Ford K, Sallam K, Wu JC.   +10 more
europepmc   +1 more source

Visualizing Specific Tubulin Isotypes and Pathogenic Variants in Cellular Microtubule Arrays

Cytoskeleton, EarlyView.
ABSTRACT Eukaryotic cells depend on dynamic microtubule arrays to execute a wide range of functions vital for life. These microtubule filaments are formed through the polymerization of α/β‐tubulin proteins, which can be generated from numerous tubulin genes, or isotypes.
Sareen Fiaz, Benjamin Powers, Jayne Aiken   +2 more
wiley   +1 more source

AI-integrated iPSC multi-omics: advancing phenotype discovery and drug target identification in rare diseases. [PDF]

Drug Discov Today
Amniouel S, Shyr ZA, Mathé EA, Zheng W.
europepmc   +1 more source