Results 231 to 240 of about 116,955 (355)

Both TALENs and CRISPR/Cas9 directly target the HBB IVS2–654 (C > T) mutation in β-thalassemia-derived iPSCs [PDF]

, 2015
Peng Xu, Ying Tong, Xiuzhen Liu, Tingting Wang, Cheng Li, Bo-yu Wang, Xiang Lv, Yue Huang, De‐Pei Liu   +8 more
openalex   +1 more source

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

The role of autophagy in microwave radiation induced toxicity in iPSC-derived cardiomyocytes. [PDF]

Curr Res Toxicol
Zhang C, Liu Z, Wang Y, Deng W, Wang H, Zhang J, Feng Q.   +6 more
europepmc   +1 more source

Visualizing Specific Tubulin Isotypes and Pathogenic Variants in Cellular Microtubule Arrays

Cytoskeleton, EarlyView.
ABSTRACT Eukaryotic cells depend on dynamic microtubule arrays to execute a wide range of functions vital for life. These microtubule filaments are formed through the polymerization of α/β‐tubulin proteins, which can be generated from numerous tubulin genes, or isotypes.
Sareen Fiaz, Benjamin Powers, Jayne Aiken   +2 more
wiley   +1 more source

Non-physiological potassium concentrations in commercial culture media trigger acute seizure-like activity in human iPSC-derived neurons. [PDF]

Sci Rep
Lyckenvik T, Izsak J, Arthursson E, Forsberg M, Johansson K, Zetterberg H, Axelsson M, Wasling P, Hanse E, Theiss S, Illes S.   +10 more
europepmc   +1 more source

Bafilomycin A1 Potentially Enhances Mesenchymal Stem Cell-derived Extracellular Vesicle Production in iPSC-MSC Cultures [PDF]

Yuping Xiao, Weiyi Yuan, Shihong Chen, Gensheng Zhang, Qing‐Ling Fu, Zhijian Cai, Xinliang Lu   +6 more
openalex   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Selective vulnerability of cerebral vasculature to <i>NOTCH3</i> variants in small vessel disease and rescue by phosphodiesterase-5 inhibitor. [PDF]

Sci Adv
Zhao X, Yu C, Adamson A, Zhao A, Zhou H, Sharma P, Wang T.   +6 more
europepmc   +1 more source

iPSC-derived Rejuvenated T-cell Therapy for Extranodal NK/T-cell Lymphoma, Nasal Type

, 2020
Miki Ando, Jun Ando, Tadahiro Honda, Midori Ishii, Hiromitsu Nakauchi, Norio Komatsu   +5 more
openalex   +2 more sources

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source