Results 231 to 240 of about 59,069 (269)

Bat crazy iPSCs

Cell, 2023
Accelerating the development of tools for non-model animal research, Dejosez et al. report the generation of induced pluripotent stem cells (iPSCs) from bats using a modified Yamanaka protocol. Their study also reveals that bat genomes harbor diverse and unusually abundant endogenous retroviruses (ERVs) that are reactivated during iPSC reprogramming.
Fathima Athar, Andrei Seluanov, Vera Gorbunova   +2 more
openaire   +2 more sources

BBS results for the iPSC/2 and iPSC/860

Future Generation Computer Systems, 1995
Abstract We present results for the BECAUSE Benchmark Set (BBS) on two machines, the Intel iPSC/2 and iPSC/860. These computers are of similar design and architecture, both being MIMD machines with processors connected together in a hypercube topology and supporting efficient through routing of messages.
R. F. Fowler, B. W. Henderson, C. Greenough   +2 more
openaire   +1 more source

QCD ON THE iPSC/860

International Journal of Modern Physics C, 1992
Performance of the Intel iPSC/860 parallel processor for Quantum Chromodynamics codes with dynamical fermions is described. After reviewing the hardware and software environments provided by the manufacturer, the data structures appropriate for the QCD code are described. Techniques for maximum performance are briefly discussed.
CLAUDE BERNARD, THOMAS A. DEGRAND, CARLETON DETAR, STEVEN GOTTLIEB, A. KRASNITZ, MICHAEL C. OGILVIE, R.L. SUGAR, D. TOUSSAINT   +7 more
openaire   +2 more sources

Identification of marker genes to monitor residual iPSCs in iPSC-derived products

Cytotherapy, 2023
Engineered tissues and cell therapies based on human induced pluripotent stem cells (iPSCs) represent a promising approach for novel medicines. However, iPSC-derived cells and tissues may contain residual undifferentiated iPSCs that could lead to teratoma formation after implantation into patients.
Myriam Lemmens, Juliane Perner, Leon Potgeter, Michael Zogg, Sineha Thiruchelvam, Matthias Müller, Thierry Doll, Annick Werner, Yoann Gilbart, Philippe Couttet, Hans-Jörg Martus, Silvana Libertini   +11 more
openaire   +2 more sources

Disease Correction the iPSC Way: Advances in iPSC-Based Therapy

Clinical Pharmacology & Therapeutics, 2011
Pluripotent stem cells possess the capacity for self-renewal and the ability to differentiate into all cell types of the three embryonic germ layers. Accordingly, given their potential use in regenerative medicine, they have long attracted the attention of researchers.
I, Sancho-Martinez, M, Li, J C, Izpisua Belmonte   +2 more
openaire   +2 more sources

Multiomics Evaluation of Human iPSCs and iPSC-Derived Neurons

Journal of Proteome Research
Human induced pluripotent stem cells (iPSCs) can be differentiated into neurons, providing living human neurons to model brain diseases. However, it is unclear how different types of molecules work together to regulate stem cell and neuron biology in healthy and disease states.
Gwang Bin Lee, Wan Nur Atiqah binti Mazli, Ling Hao   +2 more
openaire   +2 more sources

Toward Ovine iPSCs

Cellular Reprogramming, 2013
Abstract Interest in pluripotent livestock stem cells has been with us for over 2 decades, and although much has been claimed over the years, it is only recently that real progress has been achieved. The recent developments have revolved around the ability to reprogram somatic cells to become induced pluripotent stem cells (iPSCs).
openaire   +2 more sources

Timothy syndrome iPSC modeling

Molecular and Cellular Neuroscience, 2020
L-type voltage-gated calcium channels play an essential role in various physiological systems including neuronal excitation and any mutation or dysfunction in the channel has significant impact on human brain function resulting in psychiatric diseases.
Ramsey, Bekdash, Alison D, Klein, Masayuki, Yazawa   +2 more
openaire   +2 more sources

Broadcast communication delay metric for the iPSC/2 and iPSC/860 hypercubes

Proceedings of the 30th annual Southeast regional conference on - ACM-SE 30, 1992
When determining the granularity of a program to be executed in parallel, it is important to have valid information on the cost of communication for the system on which the program is to be run. Previous studies have measured the node-to-node communication performance on the Intel Hypercube systems.
C. L. McCreary, M. E. McArdle, Jerry D. McCreary   +2 more
openaire   +1 more source

CRISPRi/a Screening with Human iPSCs

2021
Identifying causative genes in a given phenotype or disease model is important for biological discovery and drug development. The recent development of the CRISPR/Cas9 system has enabled unbiased and large-scale genetic perturbation screens to identify causative genes by knocking out many genes in parallel and selecting cells with desired phenotype of ...
Masataka, Nishiga, Lei S, Qi, Joseph C, Wu   +2 more
openaire   +2 more sources