Results 161 to 170 of about 9,313 (272)

Proteolysis targeting chimera degraders target pseudokinases to treat metabolic dysfunction-associated steatohepatitis and fibrosis: Mechanisms and therapeutic insights

Pharmacological Research
Metabolic dysfunction-associated steatohepatitis (MASH, previously NASH) is the severe type of metabolic dysfunction-associated steatotic liver disease (MASLD, previously NAFLD), the most common liver condition.
Yibing Wang, Jiajing Peng
doaj   +1 more source

Climate change‐driven expansion of goosegrass highlights risks to global food production

Pest Management Science, EarlyView.
Climate change is expanding the climatic suitability of Eleusine indica into temperate agricultural regions, increasing its overlap with major soybean and maize production areas. These findings highlight a growing global threat to food security and the need for proactive weed management strategies.
Thiago Deomar Ludwig, Ednaldo Alexandre Borgato, Luis Antonio de Avila, Laura Montipó Roncaglia, Maria Imaculada Zucchi   +4 more
wiley   +1 more source

Immune-enhancing neutrophils reprogrammed by subclinical low-dose endotoxin in cancer treatment

EMBO Molecular Medicine
Despite the re-emergence of the pioneering “Coley’s toxin” concept in anti-cancer immune therapies highlighted by check-point inhibitors and CAR-T approaches, fundamental mechanisms responsible for the immune-enhancing efficacy of low-dose “Coley’s toxin”
Yao Zhang, Christina Lee, Shuo Geng, Jing Wang, Udipta Bohara, Jacqueline Hou, Ziyue Yi, Liwu Li   +7 more
doaj   +1 more source

IRAK-M Expression in Tumor Cells Supports Colorectal Cancer Progression through Reduction of Antimicrobial Defense and Stabilization of STAT3 [PDF]

, 2016
Rebecca Kesselring, Joachim Glaesner, Andreas Hiergeist, Elisabeth Naschberger, Helmut Neumann, Stefan M. Brunner, Anja K. Wege, Caroline T. Seebauer, Gudrun Köhl, Susanne Merkl, Roland S. Croner, Christina Hackl, Michael Stürzl, Markus F. Neurath, André Gessner, Hans-Juergen Schlitt, Edward K. Geissler, Stefan Fichtner‐Feigl   +17 more
openalex   +1 more source

Human Rights Economic Dividends: Estimating the Economic Effects of Preventing Discrimination

Sustainable Development, EarlyView.
ABSTRACT Economies embracing principles like nondiscrimination are presumed to reap significant rewards, while violations incur heavy costs. We call these benefits human rights economic dividends—the economic gains that arise when policymaking is guided by human rights principles.
Jose Cuesta
wiley   +1 more source

Induction of IRAK-M in melanoma induces caspase-3 dependent apoptosis by reducing TRAF6 and calpastatin levels. [PDF]

Commun Biol, 2020
Geng D, Ciavattone N, Lasola JJ, Shrestha R, Sanchez A, Guo J, Vlk A, Younis R, Wang L, Brown AJ, Zhang Y, Velasco-Gonzalez C, Tan AC, Davila E.   +13 more
europepmc   +1 more source

Sen bir yazarsın Şirinaki! [PDF]

, 1994
Taha Toros Arşivi, Dosya Adı: Ahmet Cevat Paşa-Cevat Şakir Kabaağaçlı Not: Gazetenin "Pazarın Penceresinden" köşesinde ...
Erez, Selçuk
core  

Prioritization of the Sustainable Development Goals: Developing and Testing a Novel Framework Under Varying Geographic Scales

Sustainable Development, EarlyView.
ABSTRACT This study develops and tests a novel prioritization framework for the Sustainable Development Goals (SDGs) under varying geographic scales (regional, sub‐regional, national), focusing on the Middle East and North Africa (MENA) region as a pilot case.
Lea Issa, Mutasem El Fadel
wiley   +1 more source

O4‐07‐01: IRAK‐M deletion promotes microglia‐mediated cerebral amyloid clearance in PSAPP mice [PDF]

, 2012
David Gate, Kavon Rezai‐Zadeh, Eliezer Masliah, Terrence Town   +3 more
openalex   +1 more source

Can Happiness Be Sustainable? Monitoring Global Consumption Footprints From 2015 to 2024

Sustainable Development, EarlyView.
ABSTRACT Understanding how happiness relates to resource consumption requires considering not only domestic environmental impacts but also the broader transnational effects embedded in global trade. To address this gap, this study introduces the Consumption Footprint–Happiness Ratio (CHR), a visual analytic metric that captures the intensity of ...
Chong‐Wen Chen
wiley   +1 more source