Results 101 to 110 of about 492,305 (300)

MicroRNA-Mediated Regulation of Dp53 in the Drosophila Fat Body Contributes to Metabolic Adaptation to Nutrient Deprivation

Cell Reports, 2014
Multiple conserved mechanisms sense nutritional conditions and coordinate metabolic changes in the whole organism. We unravel a role for the Drosophila homolog of p53 (Dp53) in the fat body (FB; a functional analog of vertebrate adipose and hepatic ...
Lara Barrio, Andrés Dekanty, Marco Milán   +2 more
doaj   +1 more source

Einfluss der physikalischen Raumklimabedingungen auf die physiologischen Bestimmungselemente fuer thermische Behaglichkeit. Phase 2 Tagesgang fuer thermisches Behaglichkeitsempfinden

, 1985
Available from Informationszentrum Raum und Bau (IRB), Stuttgart (DE) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische ...
Mayer, E., Informationszentrum Raum und Bau (IRB), Stuttgart (Germany), Fraunhofer-Institut fuer Bauphysik, Holzkirchen (Germany)   +2 more
core  

Inebilizumab in AQP4‐Seropositive NMOSD: One‐Year Follow‐Up From a Multicenter, Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Real‐world evidence on inebilizumab among neuromyelitis optica spectrum disorder (NMOSD) patients is lacking. This study assessed inebilizumab among Chinese patients with aquaporin 4 autoantibody (AQP4‐IgG)‐seropositive NMOSD in a real‐world setting.
Mengcui Gui, Jiayang Zhan, Wei Li, Tao Jin, Dan He, Daishi Tian, Zhijun Li, Jing Lin, Yue Li, Hongyu Zhou, Bitao Bu   +10 more
wiley   +1 more source

Diffuse MRI Edema Predicts Relapse in Cerebral Amyloid Angiopathy–Related Inflammation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify MRI predictors of relapse and quantify relapse and mortality risk in cerebral amyloid angiopathy–related inflammation (CAA‐RI). A secondary objective was to assess the association between mycophenolate mofetil use and relapse risk. Methods We performed a retrospective cohort study of 36 patients with CAA‐RI treated at the
G. Abbas Kharal, Gowtham Yerneni, Kim J. Griffin, Nicolas Thompson, Ken Uchino, Irene Katzan, Dolora Wisco, Abeer Farrag, Jayashree Sundarajan, Andrew Russman, M. Shazam Hussain   +10 more
wiley   +1 more source

Myeloid p38α signaling promotes intestinal IGF‐1 production and inflammation‐associated tumorigenesis

EMBO Molecular Medicine, 2018
The protein kinase p38α plays a key role in cell homeostasis, and p38α signaling in intestinal epithelial cells protects against colitis‐induced tumorigenesis.
Catrin Youssif, Monica Cubillos‐Rojas, Mònica Comalada, Elisabeth Llonch, Cristian Perna, Nabil Djouder, Angel R Nebreda   +6 more
doaj   +1 more source

Langzeituntersuchungen an kerngedaemmtem Mauerwerk Schlussbericht

, 1988
Available from Informationszentrum Raum und Bau (IRB), Stuttgart (DE) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische ...
Metje, W.R., Hannover Univ. (Germany). Inst. fuer Baustoffkunde und Materialpruefung, Braunschweig Technische Univ. (Germany). Amtliche Materialpruefungsanstalt fuer das Bauwesen, Institut fuer Bautechnik, Berlin (Germany), Informationszentrum Raum und Bau (IRB), Stuttgart (Germany)   +4 more
core  

High Health Care Utilization Preceding Diagnosis With Juvenile Idiopathic Arthritis

Arthritis Care &Research, EarlyView.
Objective Although early diagnosis improves long‐term outcomes, patients with juvenile idiopathic arthritis (JIA) often experience prolonged, circuitous paths to diagnosis. To inform diagnostic improvement, we sought to characterize health care utilization in the year preceding diagnosis. Methods We identified 10,021 patients with an incident diagnosis
Anna Costello, Rui Xiao, Xuemei Zhang, Jahan Jazayeri, Irit R. Rasooly, Pamela F. Weiss   +5 more
wiley   +1 more source

Identification of Neuritin 1 as a local metabolic regulator of brown adipose tissue

Nature Communications
Brown adipose tissue (BAT) plays a key role in metabolic homeostasis through its thermogenic effects and the secretion of regulatory molecules. Here we report that RAP250 haploinsufficiency stimulates BAT in mice, thus contributing to a decrease in fat ...
Manuela Sánchez-Feutrie, Montserrat Romero, Sónia R. Veiga, Núria Borràs-Ferré, Nick Berrow, Martina Ràfols, Noemí Giménez, Andrea Rodgers-Furones, Alba Sabaté-Pérez, Ángela Rodríguez Pérez, Luis Rodrigo Cataldo, Hans Burghardt, David Sebastián, Natàlia Plana, Vanessa Hernández, Laura Isabel Alcaide, Óscar Reina, Maria J. Monte, José Juan G. Marin, Manuel Palacín, Remy Burcelin, Per Antonson, Jan-Ake Gustafsson, Antonio Zorzano   +23 more
doaj   +1 more source

The Association of Physical Function With Psychosocial Patient‐Reported Outcomes in People With Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective To evaluate how modifiable psychosocial factors and fatigue relate to physical functioning in patients with systemic lupus erythematosus (SLE). Methods In this cross‐sectional study of two demographically distinct cohorts (Approaches to Positive, Patient‐Centered Experiences of Aging with Lupus [APPEAL] and California Lupus Epidemiology Study
Mrinalini Dey, Jessica Fitzpatrick, Maria Dall'Era, Charmayne Dunlop‐Thomas, Courtney Hoge, S. Sam Lim, Patricia P. Katz, Jinoos Yazdany, Laura C. Plantinga   +8 more
wiley   +1 more source

Copy number losses of oncogenes and gains of tumor suppressor genes generate common driver mutations

Nature Communications
Cancer driver genes can undergo positive selection for various types of genetic alterations, including gain-of-function or loss-of-function mutations and copy number alterations (CNA).
Elizaveta Besedina, Fran Supek
doaj   +1 more source