Results 61 to 70 of about 58,896 (242)

Prioritizing Pharmaceuticals for Environmental Monitoring in Greece: A Comprehensive Review of Consumption, Occurrence, and Ecological Risk

Toxics
Pharmaceuticals are increasingly recognized as contaminants of emerging concern, yet monitoring strategies often do not reflect actual consumption patterns or ecological risk.
Konstantina-Roxani Chatzipanagiotou, Adamantia Bon, Foteini Petrakli, George Antonaropoulos, Elias P. Koumoulos   +4 more
doaj   +1 more source

IRESpy: an XGBoost model for prediction of internal ribosome entry sites

BMC Bioinformatics, 2019
Background Internal ribosome entry sites (IRES) are segments of mRNA found in untranslated regions that can recruit the ribosome and initiate translation independently of the 5′ cap-dependent translation initiation mechanism. IRES usually function when 5′
Junhui Wang, Michael Gribskov
doaj   +1 more source

EUROPOS SĄJUNGA IR RUSIJA: KĄ REIŠKIA „IR“?

Politologija, 2015
In the article, the EU and Russia relations are analyzed as paying specific attention to the conceptual and practical weight provided for the conjunction “and” when EU–Russia relations are interpreted and practically constructed in the West. The answer which is in common use – these relations are intellectually based and practically shaped according ...
openaire   +3 more sources

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Advanced Science, EarlyView.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong   +15 more
wiley   +1 more source

Sustainability Assessment in Recombinant Human Insulin Production—Evaluating the Environmental Impacts of Microbial Growth Medium Components and Formulations

Journal of Experimental and Theoretical Analyses
According to the International Diabetes Federation, approximately 537 million adults suffered from diabetes in 2021, a number that is projected to rise to 783 million by 2045.
Konstantina-Roxani Chatzipanagiotou, Athanasios Pappas, Foteini Petrakli, George Antonaropoulos, Elias P. Koumoulos   +4 more
doaj   +1 more source

PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy

Advanced Science, EarlyView.
The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao, Lijuan Lu, Xiaoxiao Xiong, Yi Li, Donghui Hu, Duo Zhang, Zhiwei Feng, Cong Liu, Nannan Liu, Xiaoli Li, Jizhou Tan, Ting Liu, Ling Peng, Lu Lu, Huiyi Feng, Yan Zhong, Guisen Tan, Zhicheng Zhang, Liqin Huang, Chao Su, Ying Xue, Shuo Song, Wenxia Fan, Wei Wang, Fan Zou   +24 more
wiley   +1 more source

“More” Artificial mRNAs: Beyond the Art of Nature

Advanced Science, EarlyView.
Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Yuanzhe Cui, Minami Fukui, Hirohisa Ohno, Hirohide Saito   +3 more
wiley   +1 more source

First Evidence for Internal Ribosomal Entry Sites in Diverse Fungal Virus Genomes

mBio, 2018
In contrast to well-established internal ribosomal entry site (IRES)-mediated translational initiation in animals and plants, no IRESs were established in fungal viral or cellular RNAs.
Sotaro Chiba, Atif Jamal, Nobuhiro Suzuki   +2 more
doaj   +1 more source

BZW1 Drives Immune Evasion in Lung Adenocarcinoma via Ferroptosis Suppression

Advanced Science, EarlyView.
BZW1 attenuates ferroptosis by competitively binding NCOA4 and suppress ferrtinophagy‐mediated iron release. The depletion of BZW1 triggers lipid peroxidation through iron homeostasis. Extracellularly, BZW1 attenuates immunogenic cell death and reinvigorates cytotoxic T‐cell responses.
Linyao Zhao, Yue Peng, Qing Liang, Shi Liu, Yang Li, Lei Ma, Menghan Hu, Sujuan Zheng, Zhihua Liu, Shugeng Gao   +9 more
wiley   +1 more source

Insights into Structural and Mechanistic Features of Viral IRES Elements

Frontiers in Microbiology, 2018
Internal ribosome entry site (IRES) elements are cis-acting RNA regions that promote internal initiation of protein synthesis using cap-independent mechanisms.
Encarnacion Martinez-Salas, Rosario Francisco-Velilla, Javier Fernandez-Chamorro, Azman M. Embarek   +3 more
doaj   +1 more source