Results 51 to 60 of about 169,975 (290)
Eukaryotic translation initiation machinery can operate in a prokaryotic-like mode without eIF2 [PDF]
, 2008 Unlike prokaryotes, a specialized eukaryotic initiation factor 2 (eIF2), in the form of the ternary complex eIF2*GTP*Met-tRNAiMet is utilized to deliver the initiator tRNA to the ribosome within all eukaryotic cells1.
Dmitri Andreev +3 more
core +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Cuadernos de Trabajo SocialLa exclusión residencial en la experiencia de las mujeres ha sido una realidad invisibilizada donde se identifican mayores índices de violencia, a pesar de ello en la comunidad de Illes Balears no existen servicios específicos que atiendan a este perfil
Isabel Nadal-Amengual +3 more
doaj +1 more source
PLoS ONE, 2009 Giardiavirus (GLV) utilizes an internal ribosome entry site (IRES) for translation initiation in the early branching eukaryote Giardia lamblia. Unlike most of the viral IRESs among higher eukaryotes, which localize primarily within the 5'-untranslated ...
Srinivas Garlapati, Ching C Wang
doaj +1 more source
Antípoda: Revista de Antropología y Arqueología, 2023 The enactment of the National Education Law in 2006, made secondary education compulsory in Argentina. This prompted actions to expand coverage and guarantee access to this level of education to sectors and contexts that had not been reached until then ...
Cecilia Evangelina Melendez +2 more
doaj +1 more source
Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni +19 more
wiley +1 more source
Viruses, 2021 The dicistrovirus intergenic region internal ribosome entry site (IGR IRES) uses an unprecedented, streamlined mechanism whereby the IRES adopts a triple-pseudoknot (PK) structure to directly bind to the conserved core of the ribosome and drive ...
Xinying Wang +3 more
doaj +1 more source
Internal ribosomal entry site lacks secondary structure [PDF]
, 2007 The search for mechanisms of translational regulation has yielded many experimentally identified internal ribosome entry sites (IRES). Because of the lack of sequence similarity among the experimentally IRESs, it is widely assumed that IRESs posses ...
Xuhua Xia
core +1 more source
IŠORINIS IR VIDINIS TEISĖJŲ IR TEISMŲ ĮVAIZDIS
Teisė, 2016 Straipsnyje analizuojamas teisėjų (n = 171) ir įvairaus amžiaus visuomenės grupių atstovų (n = 1186) suvokto teisėjų ir teismų įvaizdžio (tam tikrų jo aspektų) pobūdis, panašumai ir skirtumai, taip pat teisėjų ir teismų įvaizdžio, tiriamųjų sukauptos patirties bei sociodemografinių charakteristikų sąsajos.
Valickas, Gintautas +2 more
openaire +3 more sources
Advanced Functional Materials, EarlyView.Development of a transparent, self‐sanitizing antimicrobial coating technology applicable to a wide range of materials and surfaces‐including touchscreens, transparent substrates, and metal, plastic, and glass‐regardless of pathogen type. The spray‐coated, UV‐cross‐linked imidazole‐based quaternary ammonium chloride materials provide broad‐spectrum ...
Surjith Kumaran +6 more
wiley +1 more source