Results 41 to 50 of about 169,975 (290)

The Avian Encephalomyelitis Virus (AEV) 5’ Untranslated Region Contains an IRES with Similarity to the Hepatitis C Virus IRES [PDF]

Iranian Journal of Public Health, 2005
Cap-independent internal initiation of protein synthesis has been shown to occur on a number of viral and cellular mRNAs. Initiation of protein synthesis is directed by an internal ribosome entry site (IRES) element within the 5’ untranslated region (UTR)
M Bakhshesh, L Roberts, G J Belsham
doaj   +2 more sources

An Overview of Tools and Challenges for Safety Evaluation and Exposure Assessment in Industry 4.0

Applied Sciences
Airborne pollutants pose a significant threat in the occupational workplace resulting in adverse health effects. Within the Industry 4.0 environment, new systems and technologies have been investigated for risk management and as health and safety smart ...
Spyridon Damilos, Stratos Saliakas, Dimitris Karasavvas, Elias P. Koumoulos   +3 more
doaj   +1 more source

Characterization of host factors associated with the internal ribosomal entry sites of foot-and-mouth disease and classical swine fever viruses

Scientific Reports, 2022
Foot-and-mouth disease virus (FMDV) and classical swine fever virus (CSFV) possess positive-sense single-stranded RNA genomes and an internal ribosomal entry site (IRES) element within their 5′-untranslated regions. To investigate the common host factors
Yutaro Ide, Bouchra Kitab, Nobumasa Ito, Riai Okamoto, Yui Tamura, Takafumi Matsui, Yoshihiro Sakoda, Kyoko Tsukiyama-Kohara   +7 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The pathway of hepatitis C virus mRNA recruitment to the human ribosome. [PDF]

, 2009
Eukaryotic protein synthesis begins with mRNA positioning in the ribosomal decoding channel in a process typically controlled by translation-initiation factors.
Doudna, Jennifer A, Fraser, Christopher S, Hershey, John WB   +2 more
core  

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

¿Desde lejos no se ve? Conectando territorios a partir de las relaciones visuales entre el arte rupestre de Los Llanos de La Rioja y el Noroeste argentino

Relaciones de la Sociedad Argentina de Antropología, 2023
En la década de 1940 Salvador Canals Frau propuso que las sociedades prehispánicas que habitaron el área de Los Llanos riojanos habrían permanecido aisladas de otras poblaciones vecinas, generando una cultura material, una lengua y una identidad propias.
Ezequiel Gilardenghi, Luis Tissera, Tomaso Muzzigoni, Héctor Biurrun, Aldana Brizuela   +4 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Polypyrimidine tract binding protein-1 (PTB1) is a determinant of the tissue and host tropism of a human rhinovirus/poliovirus chimera PV1(RIPO). [PDF]

PLoS ONE, 2013
The internal ribosomal entry site (IRES) of picornavirus genomes serves as the nucleation site of a highly structured ribonucleoprotein complex essential to the binding of the 40S ribosomal subunit and initiation of viral protein translation.
Nusrat Jahan, Eckard Wimmer, Steffen Mueller   +2 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source