Results 41 to 50 of about 78,348 (310)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Violencias machistas y exclusión residencial: barreras a la intervención desde la experiencia profesional en Illes Balears

Cuadernos de Trabajo Social
La exclusión residencial en la experiencia de las mujeres ha sido una realidad invisibilizada donde se identifican mayores índices de violencia, a pesar de ello en la comunidad de Illes Balears no existen servicios específicos que atiendan a este perfil
Isabel Nadal-Amengual, Paloma Martín Martín, Clara Ferragut Moranta, Sara Bouza Bañobre   +3 more
doaj   +1 more source

Sequences of primers used to amplify C9orf82 expression for subsequent cloning into pMX-IRES-GFP vector.

, 2019
Sequences of primers used to amplify C9orf82 expression for subsequent cloning into pMX-IRES-GFP vector.
Ji-Ying Song (167443), Muhammad Assad Aslam (6195116), Ivo J. Huijbers (251383), Heinz Jacobs (6717), Ruud H. Wijdeven (6195128), Mir Farshid Alemdehy (6195119), Fitriari Izzatunnisa Muhaimin (6195125), Jacques Neefjes (116151), Colin E. J. Pritchard (6195122)   +8 more
core   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Resurrection of a Viral Internal Ribosome Entry Site from a 700 Year Old Ancient Northwest Territories Cripavirus

Viruses, 2021
The dicistrovirus intergenic region internal ribosome entry site (IGR IRES) uses an unprecedented, streamlined mechanism whereby the IRES adopts a triple-pseudoknot (PK) structure to directly bind to the conserved core of the ribosome and drive ...
Xinying Wang, Marli Vlok, Stephane Flibotte, Eric Jan   +3 more
doaj   +1 more source

Tutorial on Reasoning for IR & IR for Reasoning

Information retrieval has long focused on ranking documents by semantic relatedness. Yet many real-world information needs demand more: enforcement of logical constraints, multi-step inference, and synthesis of multiple pieces of evidence. Addressing these requirements is, at its core, a problem of reasoning.
Hoveyda, M., Eustratiadis, P., Vries, A.P. de, Rijke, M. de   +3 more
openaire   +3 more sources

PSYNDEX Tests Review für IRES-3 - Indikatoren des Reha-Status - Version 3

, 2017
This is a PSYNDEX Tests Review of IRES-3 - Indikatoren des Reha-Status - Version 3. PSYNDEX Tests Reviews are written in German and describe and evaluate psychological and educational tests used in the German-speaking countries.
Antony, Lena
core   +1 more source

Problematic Internet Use in Frontotemporal Dementia: A Case Series

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The present study investigated problematic internet use (PIU) among 61 patients with frontotemporal dementia (FTD) compared to a cohort of 354 patients with mild cognitive impairment (MCI) and Alzheimer's dementia. PIU was identified in 22.9% of FTD patients compared to only 0.8% of AD patients (p < 0.001). Behaviors included compulsive social
Daniele Urso, Giuseppe Volpe, Agnese Valguarnera, Davide Vilella, Alessandra Vitulli, Valentina Gnoni, Alessia Giugno, Eleonora Rollo, Mark D. Griffiths, Giancarlo Logroscino   +9 more
wiley   +1 more source

Giardiavirus internal ribosome entry site has an apparently unique mechanism of initiating translation.

PLoS ONE, 2009
Giardiavirus (GLV) utilizes an internal ribosome entry site (IRES) for translation initiation in the early branching eukaryote Giardia lamblia. Unlike most of the viral IRESs among higher eukaryotes, which localize primarily within the 5'-untranslated ...
Srinivas Garlapati, Ching C Wang
doaj   +1 more source

La relazione Ires per il 2011 [PDF]

, 2012
- Indice #4- Società, economia e territorio: il quadro generale dell'economia #16- Agricoltura #66- Artigianato #77- L'auto e la Fiat #84- Costruzioni #95- Commercio #100- Turismo #119- Dinamiche ICT nel 2010 #125- La sicurezza stradale #140- Governo ...
Ires
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